Lizak

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Lizak: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Lizak

ATX code: R02AA20

Active ingredient: dequalinium chloride + lysozyme hydrochloride

Producer: Farmak, PJSC (Ukraine)

Description and photo update: 2019-26-08

Lizak is a complex agent for topical application with a pronounced antiseptic, fungicidal and antibacterial effect.

Release form and composition

Dosage form Lizak - lozenges with three types of flavors: mint and anise, orange or chocolate (6 or 10 pieces in a blister strip, in a cardboard box 1 or 2 packs).

Content of active ingredients in 1 tablet:

Dequalinium chloride - 0.25 mg;
Lysozyme hydrochloride - 10 mg.

Also, the tablet contains auxiliary components, including lactose monohydrate.

Pharmacological properties

Pharmacodynamics

Lizak is a combined preparation with a well-defined local antiseptic, antifungal and antibacterial effect. The therapeutic effect of the agent is due to the properties of its constituent components.

Dequalinium chloride is one of the local antiseptics of the quinoline group, it has antiseptic properties (mainly local). The antibacterial effect is manifested mainly against gram-positive and gram-negative microorganisms, antifungal activity against Candida albicans, some types of trichophytos and epidermophytos.

The antibacterial effect of dequalinium chloride is based on the following properties:

denaturation of proteins and enzymes of the pathogen (by depolymerization and dissolution), as well as inactivation and glycolysis of dehydrogenases;
violation of protein synthesis at the level of ribosomes;
cytolysis of the cell membrane.

The bacteriostatic activity is based on a surface active cationic action, which is more pronounced in relation to gram-positive than to gram-negative microorganisms.

Lysozyme is a mucopolysaccharide that is effective against gram-positive bacteria (provided by the conversion of insoluble polysaccharides of the cell wall into soluble mucopeptides). The substance is also effective against gram-negative bacteria, viruses and fungi. Lysozyme increases the body's non-specific defenses and has a local anti-inflammatory effect.

Pharmacokinetics

The absorption of dequalinium chloride is negligible.

Lysozyme is well absorbed from the gastrointestinal tract. The peak concentration of the substance in the blood is reached in 1–1.5 hours. It is widely distributed in the tissues of the body, the accumulation is noted in the mucous membranes. It is hydrolyzed by intestinal enzymes, excreted in the urine as a metabolite.

Indications for use

According to the instructions, Lizak is used in the treatment of inflammatory diseases of the oral cavity and pharynx caused by microorganisms sensitive to the drug:

Dental pathologies, including gingivitis (ulcerative, fibrous and catarrhal);
Aphthous stomatitis;
Oral candidiasis;
Pharyngitis, laryngitis, tonsillitis, glossitis and other inflammatory diseases of infectious genesis as part of complex or monotherapy.

In addition, Lizak is prescribed to patients after surgery in the mouth or throat to prevent infectious diseases.

Contraindications

Galactosemia, lactase deficiency, glucose-galactose malabsorption;
Age up to 4 years;
Individual hypersensitivity to drug components.

With caution, it is recommended to prescribe Lizak tablets during breastfeeding.

The advisability of using the drug during pregnancy is determined by the doctor, comparing the expected effect for the mother and the real harm to the fetus.

Instructions for the use of Lizak: method and dosage

Lozenges are taken buccally, that is, without swallowing or chewing, but holding in the mouth until they are completely dissolved. The break between taking the pill and eating should be 30 minutes or more.

The doctor prescribes the drug on the basis of clinical indications.

Recommended dosage:

Patients over 12 years old: the initial dose is 1 tablet every 2-3 hours, if the condition improves, the interval between doses should be increased to 4 hours. The daily dose should not exceed 10 tablets;
Children aged 4-12 years: 1 tablet every 3 hours for acute infection, as the clinical picture improves, it is recommended to increase the interval between doses to 4 hours. The daily dose for children is no more than 5 tablets.

The duration of treatment depends on the indication. It is recommended to continue taking the drug for at least 2 days after normalization of the condition to prevent recurrence of the disease.

In the absence of a therapeutic effect after 7 days of treatment, you must contact your doctor to verify the diagnosis or correct the treatment regimen.

Side effects

Despite the fact that Lizak is well tolerated by adults and children, in rare cases, the use of tablets can cause side effects:

Allergic reactions: itching, skin rash, urticaria;
Digestive system: nausea, severe dryness of the oral mucosa, violation of the microflora of the oral cavity;
Others: a burning sensation and / or irritation in the mouth when the tablets are resorbed.

Overdose

There is no information.

special instructions

If signs of adverse reactions appear, the drug should be canceled.

Influence on the ability to drive vehicles and complex mechanisms

Taking the drug does not affect the performance of work requiring increased concentration of attention (driving vehicles, working with complex mechanisms).

Application during pregnancy and lactation

Lysac during pregnancy / lactation should be used with caution after assessing the ratio of the expected benefit to the possible risk (no controlled studies have been conducted).

Pediatric use

Lizak tablets are contraindicated for patients under 4 years of age.

Drug interactions

The simultaneous reception of Lizak and kayexalat can lead to severe damage to the mucous membrane of the gastrointestinal tract.

Anionic detergents that make up the toothpaste reduce the antimicrobial effect of the drug.

Analogs

Lizak's analogues are: Angisept, Ingalipt, Imupret, Pantestin, Cameton, Hepilor, Strepsils, Medasept, Tantum Verde, Sangisept, Decatilen, Etonia, Tonsilotren, Septefril.

Terms and conditions of storage

Store in a dry place at temperatures up to 25 ° C. Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Lizak

Reviews about Lizak are different. Many users are satisfied with the effectiveness of the drug, noting also the pleasant taste and the possibility of using it in children. In other cases, they indicate a lack or complete absence of a therapeutic effect.

The price of Lizak in pharmacies

The price of Lizak is unknown, since the drug is not available in pharmacies. The approximate cost of analogs: Laripront (20 tablets for sucking) - 189-233 rubles, Ingalipt (aerosol for topical use, 1 bottle of 30 ml) - 68-97 rubles, Strepsils (24 or 36 tablets for sucking) - 158– 191 or 229–257 rubles.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!