Inferon
Inferon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Inferon
ATX code: L03AB01
Active ingredient: interferon alpha (Interferon alfa)
Producer: Microgen FSUE NPO (Russia)
Description and photo update: 2019-11-07
Inferon - an immunomodulatory drug with antiviral action; cytokine.
Release form and composition
The drug is produced in the form of a lyophilisate for the preparation of a solution for intramuscular (i / m) administration: hygroscopic porous mass in the form of a powder or tablet from white to white with a brown tint (1 dose of lyophilisate in an ampoule, 2 ml of solvent in an ampoule, in a cardboard box 10 ampoules with the drug without solvent or 5 ampoules with lyophilisate complete with 5 ampoules of solvent and instructions for using Inferon, if necessary, put a knife or ampoule scarifier in the box).
1 ampoule (1 dose) of the drug contains:
- active substance: interferon alpha - at least 10,000 international units (ME);
- additional component: sucrose.
Solvent - 0.9% sodium chloride injection.
Pharmacological properties
Inferon is a mixture of alpha-type interferons, which are produced by leukocytes from healthy donors in order to protect against the effects of the interferonogen virus. The preparation does not contain preservatives or antibiotics. It also lacks hepatitis B virus surface antigen and antibodies to human immunodeficiency virus (HIV) 1, HIV 2 and hepatitis C virus.
Pharmacodynamics
Inferon exhibits antiviral and immunomodulatory effects. The drug enhances the phagocytic activity of monocytes / macrophages and polymorphonuclear neutrophils, an increase in the content of leukocytes (with leukopenia), T-lymphocytes (especially T-helpers) and their functional activity. The immunomodulator also counteracts the development of cytopenia and the phenomena of immunosuppression caused by cytostatic chemotherapy and radiotherapy. When performing intramuscular injections, the immunobiological effects of the drug persist for up to 3 days.
Indications for use
- therapy of viral infections in children and adults in combination with symptomatic and etiotropic agents;
- correction of immunodeficiency states against the background of acute and chronic infections of various etiologies.
Also, Inferon is indicated for use in the course of courses of radio and chemotherapy in patients with cancer.
Contraindications
Absolute:
- acute myocardial infarction;
- autoimmune diseases (including history data);
- renal failure;
- epilepsy and / or dysfunction of the central nervous system (CNS);
- diabetes mellitus with ketoacidosis;
- pregnancy and lactation;
- hypersensitivity to drugs of protein origin.
Relative (Inferon should be used with caution):
- postinfarction cardiosclerosis;
- arrhythmias;
- oppression of bone marrow hematopoiesis.
Inferon, instructions for use: method and dosage
Inferon is administered intramuscularly. One dose of lyophilisate (contents of 1 ampoule) is diluted in the accompanying solvent - in 2 ml of 0.9% sodium chloride solution for injection. Dilution time should not exceed 1.5 minutes. The prepared preparation is a transparent, colorless or brownish solution without sediment and impurities.
Children under 1 year old should use ½ dose of lyophilisate (5000 IU), children and adolescents from 1 year to 18 years old, and adults - 1 dose (10,000 IU). When treating children under 1 year of age with the drug, the course should not exceed 30 days.
The recommended dosage regimen of Inferon, depending on the indications:
- severe and moderate forms of influenza and other acute respiratory viral infections (ARVI): 1 injection daily for the first 3-5 days, further administration is carried out every other day; the general course - 6-8 injections, if necessary, it is allowed to extend the course until a steady improvement in the condition is observed;
- acute viral hepatitis: 1 injection daily for the first 3–7 days, further administration is carried out after 1–2 days; the general course is 14 injections, the drug treatment can be continued until a stable normalization of biochemical parameters and clinical symptoms is achieved;
- inhibition of phagocytic activity, leuko- and lymphopenia and other changes in the blood count, as well as deterioration of subjective assessments of health during the course of radio- and chemotherapy in cancer patients: 1 injection 2-3 times in 7 days during the entire course of cytostatic therapy and another for 14 days after its completion.
Side effects
Against the background of the use of Inferon, the occurrence of a flu-like syndrome may occur - malaise, headache, chills, fever, myalgia. The severity of these symptoms is highest during the first 7 days of the course, and then gradually decreases.
If any other adverse reactions develop during the treatment period, it is necessary to consult a specialist.
Overdose
There are no data on Inferon overdose.
special instructions
During therapy with alpha-type interferons, it is recommended to monitor liver function indicators and the content of blood corpuscles.
In order to eliminate side effects in the form of flu-like symptoms, paracetamol should be taken simultaneously with the drug.
Influence on the ability to drive vehicles and complex mechanisms
Patients driving vehicles or other complex moving mechanisms should be careful while using Inferon.
Application during pregnancy and lactation
Treatment with the drug during pregnancy and lactation is contraindicated.
Pediatric use
In children, the use of Inferon is possible according to the dosage regimen.
With impaired renal function
In patients with renal insufficiency, the use of an immunomodulating agent is contraindicated.
For violations of liver function
Inferon is used to treat acute viral hepatitis.
Drug interactions
It is required to avoid the combined use of Inferon with drugs / substances that lead to CNS depression, immunosuppressants and ethanol.
Analogs
Analogs of Inferon are: Human leukocyte interferon, Alfaferon, dry human leukocyte interferon, liquid human leukocyte interferon, Lokferon.
Terms and conditions of storage
Store out of the reach of children at a temperature of 2-8 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Inferon
The few reviews about Inferon found on medical websites are rather ambiguous. According to one group of patients, the drug is a fairly effective tool used in the treatment of acute respiratory viral infections, correction of immunodeficiency states against the background of the development of infections and in cancer patients during the course of radio- and chemotherapy.
At the same time, another group of patients and some doctors are skeptical about the treatment with the drug as an antiviral agent, since they were unhappy with the results of its use in ARVI. Also, some reviews indicate the lack of clinical trials, the data of which could confirm the therapeutic efficacy of the immunomodulator in the treatment of viral infections.
The price of Inferon in pharmacies
The price of Inferon, a lyophilisate for the preparation of a solution for injection (10,000 IU in an ampoule), can be 1550–1800 rubles. per package containing 10 ampoules.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
