Nalgezin
Nalgezin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Prices in pharmacies
Latin name: Nalgesin
ATX code: M01AE02
Active ingredient: naproxen (naproxen)
Manufacturer: KRKA dd (Slovenia)
Description and photo update: 2019-10-09
Prices in pharmacies: from 170 rubles.
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Nalgezin is a non-steroidal anti-inflammatory drug (NSAID).
Release form and composition
The drug is produced in film-coated tablets: blue, biconvex, oval (10 pcs. In blisters, in a cardboard box 1 or 2 blisters and instructions for the use of Nalgezin).
Active ingredient: naproxen sodium, 1 tablet - 275 mg.
Excipients: purified water, talc, microcrystalline cellulose, magnesium stearate, povidone.
Shell composition: opadry YS-1-4215, consisting of hypromellose, titanium dioxide (E171), macrogol and indigo carmine dye (E132).
Pharmacological properties
Pharmacodynamics
Naproxen is the active substance of Nalgezin, which has analgesic, antipyretic and anti-inflammatory effects. The mechanism of action is based on non-selective inhibition of the activity of cyclooxygenase 1 and 2 (COX-1 and -2).
The tablets dissolve well and are quickly absorbed from the gastrointestinal tract, which provides a rapid onset of the analgesic effect.
Pharmacokinetics
Absorption of naproxen from the gastrointestinal tract is fast and complete, bioavailability is 95% (food intake has practically no effect on completeness and absorption rate).
The time to reach the maximum concentration of the substance is from 1 to 2 hours, the connection with plasma proteins is more than 99%, the half-life is in the range of 12-15 hours.
Metabolism occurs in the liver to dimethylnaproxen, the enzyme system CYP2C9 is involved in the process. The clearance is 0.13 ml / min / kg.
Excretion: 98% - by the kidneys (of which 10% - unchanged), 0.5-2.5% - with bile. Equilibrium concentration is achieved after 2-3 days of therapy (after taking 4-5 doses).
In patients with renal insufficiency, accumulation of metabolites may occur.
Indications for use
- Mild to moderate pain syndrome: lumboischialgia, ossalgia, neuralgia, myalgia, post-traumatic pain syndrome (bruises or sprains) with inflammation, adnexitis, algomenorrhea, migraine, headache and toothache, as well as postoperative pain (in gynecology, orthopedics, traumatology -facial surgery);
- Diseases of the musculoskeletal system: ankylosing spondylitis (ankylosing spondylitis), arthritis (juvenile chronic, psoriatic, rheumatoid, gouty), bursitis, tendovaginitis, rheumatic soft tissue lesions, osteoarthritis of the spine and peripheral joints (including radicular syndrome);
- Infectious-inflammatory ENT diseases, accompanied by severe pain syndrome (as part of complex therapy): tonsillitis, pharyngitis, otitis media;
- Feverish syndrome caused by infectious or colds.
Nalgezin is used for symptomatic therapy (i.e., to reduce inflammation and pain, reduce fever). It has no effect on the progression of the disease itself.
Contraindications
Absolute:
- The period of exacerbation of inflammatory bowel diseases (Crohn's disease, ulcerative colitis);
- Erosive and ulcerative lesions of the gastric mucosa and 12 duodenal ulcer;
- The presence of gastrointestinal bleeding;
- The period after coronary artery bypass grafting;
- Cerebrovascular and other bleeding, hemostasis disorders;
- Oppression of bone marrow hematopoiesis;
- Active liver disease or severe liver failure;
- Progressive kidney disease, severe renal failure (creatinine clearance less than 20 ml / min), incl. confirmed hyperkalemia;
- Pregnancy and lactation;
- Children under 9 years old and / or body weight up to 27 kg;
- The presence in the patient's history of data on the development of an attack of bronchial obstruction, urticaria, rhinitis after taking acetylsalicylic acid (ASA) or other NSAIDs;
- Hypersensitivity to the components of Nalgezin or other NSAIDs, including ASA.
Relative (special care must be taken during treatment due to the risk of complications):
- Cardiac ischemia;
- Cerebrovascular disease;
- Congestive heart failure;
- Dyslipidemia / hyperlipidemia;
- Diabetes;
- Peripheral artery disease;
- Creatinine clearance from 20 to 60 ml / min;
- Anamnestic data on the development of ulcerative lesions of the gastrointestinal tract and / or the presence of Helicobacter pylori infection;
- Smoking;
- Severe somatic diseases;
- Blood clotting disorders;
- Bronchial asthma;
- Elderly age;
- Frequent alcohol consumption;
- Long-term use of NSAIDs;
- Concomitant treatment with the following drugs: selective serotonin reuptake inhibitors (eg paroxetine, fluoxetine, sertraline, citalopram), oral glucocorticosteroids (eg, prednisolone), antiplatelet agents (eg clopidogrel, ASA), anticoagulants (eg, warfarin)
- Children age 9-12 years old.
Nalgezin, instructions for use: method and dosage
Nalgezin tablets are taken orally.
When using the drug as an anesthetic, the average daily dose for adults is 550-1100 mg (2-4 tablets). In case of very severe pain, but provided that there have been no diseases of the gastrointestinal system in the past, the doctor may increase the dose to 1650 mg (6 tablets). However, at this dose, Nalgezin can be taken for no more than 2 weeks.
When using Nalgezin as an antipyretic agent, you can first take 2 tablets at once, then you can take 1 tablet every 6-8 hours.
Recommended doses of Nalgezin for adults for other indications:
- Prevention of migraine attacks: 2 tablets 2 times a day. If within 4-6 weeks the intensity, frequency and duration of attacks do not decrease, the drug should be canceled;
- The first signs of a migraine attack: 3 tablets once, if necessary, another 1-2 tablets, but not earlier than after 30 minutes;
- Menstrual pains, cramps and pain after the introduction of intrauterine devices, other gynecological pains: initial dose - 2 tablets, further - 1 tablet every 6-8 hours;
- Acute gout attack: initial dose - 3 tablets, after 8 hours - 2 tablets, then - 1 tablet every 8 hours until the attack stops;
- Rheumatoid diseases: the average initial dose is 2-4 tablets per day (taken in the morning and in the evening, while the morning and evening doses do not have to be the same). With severe night pain and / or morning stiffness, for diseases whose leading symptom is pain, as well as in cases when the patient is transferred to Nalgezin from other NSAIDs taken in high doses, the initial daily dose of naproxen can be increased to 3-6 tablets … Depending on the prevalence of symptoms in the future, the daily dose can be changed by the doctor.
For children over 9 years old (weighing at least 27 kg), Nalgezin is prescribed at a dose of 10 mg / kg / day, divided into 2 doses.
Elderly patients are advised to prescribe lower doses.
Side effects
- Digestive system: ulcerative stomatitis, nausea, diarrhea, dyspepsia, abdominal pain, constipation, erosive and ulcerative lesions and bleeding in the gastrointestinal tract, bloody vomiting, jaundice, melena, liver dysfunction, increased activity of liver enzymes;
- Central nervous system: drowsiness, headache, depression, myalgia and muscle weakness, malaise, slow reaction rate, insomnia, aseptic meningitis, sleep disturbances, hearing loss, cognitive dysfunction, inability to concentrate, dizziness;
- Skin: purpura, excessive sweating, alopecia, ecchymosis, photodermatosis, itching;
- Cardiovascular system: palpitations, vasculitis, shortness of breath, swelling, congestive heart failure;
- Genitourinary system: renal failure, nephrotic syndrome, renal papillary necrosis, hematuria, glomerulonephritis, interstitial nephritis, menstrual irregularities;
- Respiratory system: eosinophilic pneumonitis;
- Hematopoietic organs: thrombocytopenia, leukopenia, aplastic anemia, granulocytopenia, eosinophilia;
- Sense organs: tinnitus, hearing and visual impairment;
- Allergic reactions: epidermal necrosis, angioedema, urticaria, erythema multiforme, skin rash, Stevens-Johnson syndrome;
- Others: hypoglycemia, hyperglycemia, hemolytic anemia, hyperthermia, thirst.
Most often, side effects occur when Nalgezin is taken in high doses.
Overdose
The main symptoms are:
- Significant overdose: drowsiness, dyspeptic disorders (heartburn, vomiting, nausea, abdominal pain), weakness, tinnitus, irritability;
- Severe cases: melena, bloody vomiting, seizures, impaired consciousness, renal failure.
Therapy: gastric lavage, symptomatic treatment comprising administration of activated charcoal, antacids, H blockers 2 receptors, a proton pump inhibitor.
Hemodialysis is ineffective.
special instructions
To reduce the risk of side effects from the digestive system, it is recommended to use the minimum effective dose of Nalgesin in the shortest possible courses.
If fever and / or pain persists or worsens, discontinue the drug and consult a doctor.
Without a doctor's prescription, it is prohibited to take Nalgezin simultaneously with other analgesics or anti-inflammatory drugs.
In the case of a planned surgical intervention, Nalgezin should be canceled 48 hours before. The same applies to conducting a study to determine 17-corticosteroids, as well as 5-hydroxyindoleacetic acid in urine.
Patients on a diet with limited salt intake should take into account that each Nalgezin tablet contains 25 mg of sodium.
Influence on the ability to drive vehicles and complex mechanisms
Naproxen has a negative effect on the speed of reactions, which must be taken into account by vehicle drivers and people employed in industries that require increased attention.
Application during pregnancy and lactation
Nalgezin is not prescribed during pregnancy / lactation.
Pediatric use
- Age up to 9 years or body weight less than 27 kg: therapy is contraindicated;
- Age 9-12 years: Nalgezin tablets are prescribed with caution, only on the recommendation of a doctor.
With impaired renal function
- Severe renal failure (in patients with creatinine clearance less than 20 ml / min), including confirmed hyperkalemia, progressive kidney disease: therapy is contraindicated;
- Renal failure (with creatinine clearance from 20 to 60 ml / min): Nalgezin is prescribed with caution.
For violations of liver function
Nalgezin is contraindicated in patients with active liver disease and severe liver failure.
Use in the elderly
For elderly patients, Nalgezin is prescribed under medical supervision.
Drug interactions
- Anticoagulants: increased bleeding time;
- Other NSAIDs: risk of side effects;
- Propranolol and other beta-blockers: a decrease in their antihypertensive effect, the risk of developing renal failure;
- Furosemide: suppression of its natriuretic action;
- Lithium preparations: an increase in the concentration of lithium in the blood plasma;
- Probenecid: increased plasma levels of naproxen;
- Cyclosporine: risk of developing renal failure;
- Phenytoin, methotrexate, sulfonamides: slowing down their excretion, the risk of developing their toxic effects;
- Magnesium and aluminum-containing antacids: reducing the absorption of naproxen.
Analogs
Analogs of Nalgezin are: Algezir Ultra, Naproxen, Naproxen-Acri, Nalgezin Forte, Promax, Tsefekon.
Terms and conditions of storage
Keep out of the reach of children, at temperatures up to 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Nalgezin
Most of the reviews about Nalgezin are positive. The drug is recommended for fast and long-term pain relief, a wide range of applications. The disadvantages most often include the high cost and the likelihood of developing side effects.
The price of Nalgezin in pharmacies
The approximate price for Nalgezin is 135–184 rubles. (10 tablets in a package) or 249-289 rubles. (20 tablets in the package).
Nalgezin: prices in online pharmacies
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Drug name Price Pharmacy |
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Nalgezin 275 mg film-coated tablets 10 pcs. 170 RUB Buy |
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Nalgezin tablets 275mg 10 pcs. 188 r Buy |
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Nalgezin forte 550 mg film-coated tablets 10 pcs. 252 RUB Buy |
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Reviews Nalgezin Forte 252 RUB Buy |
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Nalgezin Forte tablets 550mg 10 pcs. 255 RUB Buy |
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Nalgezin 275 mg film-coated tablets 20 pcs. 256 RUB Buy |
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Nalgezin tablets 275mg 20 pcs. 276 r Buy |
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Nalgezin Forte tablets p.o. 20 pcs. 398 RUB Buy |
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Nalgezin forte 550 mg film-coated tablets 20 pcs. 398 RUB Buy |
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Reviews Nalgezin Forte 398 RUB Buy |
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Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
