Claridol
Claridol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Klaridol
ATX code: R06AX13
Active ingredient: loratadine (loratadine)
Manufacturer: Shreya Life Science Pvt. Ltd. (India)
Description and photo updated: 22.11.2018
Prices in pharmacies: from 86 rubles.
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Claridol is an antihistamine.
Release form and composition
Dosage forms of Claridol:
- tablets: round, flat, with beveled edges, almost white / white, with a break line on one side (7, 8, 10 and 16 pcs. in blisters, in a cardboard box 1, 2, 3, 4, 5 or 10 blisters; 10 pcs. In strips, in a cardboard box 1, 2, 3, 4, 5 or 10 strips);
- syrup: clear orange liquid with a pleasant aroma and sweet taste (50, 60, 100 and 120 ml each in amber glass bottles, 1 bottle in a cardboard box).
Composition of 1 tablet:
- active substance: loratadine - 10 mg;
- auxiliary components: sodium methylparaben, sodium starch glycolate, magnesium stearate, anhydrous colloidal silicon dioxide, microcrystalline cellulose, purified talc, starch, purified water.
Composition of 1 ml of syrup:
- active substance: loratadine - 1 mg;
- auxiliary components: sodium propylparaben, disodium edetate, sodium benzoate, propylene glycol, sodium methylparaben, sodium saccharin, citric acid, sorbitol solution, sucrose, mixed fruit flavor American ice cream, Sun Sunset dye, purified water.
Pharmacological properties
Pharmacodynamics
Loratadine is a long-acting H 1 -histamine receptor blocker. It has antiallergic, antipruritic and antiexudative activity. Inhibits the release of leukotriene C4 and histamine from mast cells. Reduces capillary permeability, relieves spasms of smooth muscles, prevents the development of tissue edema. Prevents the development of allergic reactions and facilitates their course.
Antiallergic effect of Claridol develops within 30 minutes after taking the drug, reaches a maximum after 8-12 hours, lasts 24 hours.
Loratadine practically does not penetrate the blood-brain barrier, therefore it is not addictive and does not affect the central nervous system.
Pharmacokinetics
After oral administration of Claridol, loratadine is rapidly and completely absorbed in the gastrointestinal tract. The maximum concentration (Cmax) reaches within 1.3–2.5 hours. With simultaneous food intake, this time increases by 1 hour. In elderly people, Cmax is 50% higher, with alcoholic liver damage, Cmax increases depending on the severity of the disease.
Loratadine is 97% bound to plasma proteins. It is metabolized in the liver mainly with the participation of cytochrome P450 isoenzymes CYP3A4, to a lesser extent - CYP2D6. The active metabolite is descarboethoxyloratadine.
The equilibrium plasma concentration of loratadine and its metabolite is reached on the fifth day after administration.
The drug does not penetrate the blood-brain barrier.
The half-life of loratadine averages 8.4 hours (from 3 to 20 hours), for descarboethoxyloratadine, an average of 28 hours (from 8.8 to 92 hours), in elderly patients, respectively, an average of 18.2 hours (from 6.7 up to 37 hours) and 17.5 hours (from 11 to 38 hours). With alcoholic liver damage, this period increases depending on the severity of the disease.
The drug is excreted in the bile and kidneys.
In chronic renal failure and during hemodialysis, the pharmacokinetics of loratadine practically does not change.
Indications for use
- allergic itchy dermatoses;
- allergic rhinitis (seasonal or perennial);
- allergic reactions to insect bites;
- itching of various etiologies;
- urticaria (including chronic idiopathic);
- hay fever;
- conjunctivitis;
- Quincke's edema;
- pseudo-allergic reactions.
Contraindications
- children under 2 years old;
- period of pregnancy and lactation;
- the presence of hypersensitivity to any of the components of the drug.
According to the instructions, Claridol should be used with caution in the presence of liver failure.
Instructions for the use of Claridol: method and dosage
Claridol is taken orally.
Recommended dosage:
- adults, children over 12 years old and children weighing> 30 kg: 10 mg [1 tablet or 10 ml (2 teaspoons) of syrup] 1 time per day;
- children 2–12 years old: 5 mg [½ tablet or 5 ml (1 teaspoon) of syrup] 1 time per day.
For patients with impaired hepatic function, the drug is prescribed in a daily dose of 5 mg.
Side effects
- adults: dry mouth, gastrointestinal disorders (nausea, vomiting, gastritis), fatigue, drowsiness, headache, allergic reactions (rash, anaphylaxis); in rare cases - palpitations, alopecia, tachycardia, liver dysfunction, anaphylaxis;
- children: rarely - sedation, nervousness, headache.
The reported adverse events occurred with a frequency of ≥ 2%, which is approximately comparable to that with placebo.
Overdose
Loratadine overdose is manifested by headache, drowsiness, tachycardia. It is recommended to induce vomiting, gastric lavage, and take activated charcoal.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
During treatment, it is recommended to refrain from performing potentially hazardous activities that require increased attention and speed of reactions.
Application during pregnancy and lactation
Claridol is contraindicated in pregnant and breastfeeding women.
Pediatric use
The drug is contraindicated in children under 2 years of age.
For violations of liver function
Claridol should be used with caution if hepatic impairment is concomitant. The recommended daily dose is 5 mg.
Drug interactions
Cimetidine, erythromycin and ketoconazole, with simultaneous use, increase the concentration of loratadine in the blood plasma, however, there are no clinical manifestations and changes in the electrocardiogram.
The effectiveness of loratadine is reduced by ethanol and inducers of microsomal oxidation (tricyclic antidepressants, rifampicin, barbiturates, phenylbutazone, phenytoin, zixorin).
Analogs
Claridol analogs are Allerpriv, Claritin, Clarifer, Klarnedin, Clarisens, Lomilan, Lomilan Solo, LoraGEXAL, Loratadin, Loratadin-OBL, Loratadin-Akrikhin, Loratadin-Teva, Loratadin-Hemofarm, Loratadin-Ekointa.
Terms and conditions of storage
Store at temperatures up to 30 ° C in a dry place out of reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Claridol
Most of the reviews about Claridol are positive: the drug effectively eliminates itching, redness, swelling and other conditions associated with allergic diseases. However, the time of onset of action of loratadine and the duration vary considerably.
In rare negative reviews, there are complaints about the development of side effects or the lack of effect.
The price of Claridol in pharmacies
Approximate prices for Claridol: 79–95 rubles. for 7 tablets, 188-195 rubles. for 10 tablets, 73-80 rubles. for 100 ml of syrup.
Claridol: prices in online pharmacies
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Drug name Price Pharmacy |
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Claridol 1 mg / ml syrup 100 ml 1 pc. RUB 86 Buy |
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Claridol 10 mg tablets 10 pcs. 119 RUB Buy |
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Claridol 10mg tablets 10 pcs. 156 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
