Cervicon-DIM
Cervikon-DIM: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Cervicon-DIM
ATX code: L01XX
Active ingredient: diindolylmethane (Diindolylmethane)
Producer: Altpharm LLC (Russia)
Description and photo update: 2020-30-03
Prices in pharmacies: from 1559 rubles.
Buy
Cervikon-DIM is an antineoplastic drug for local drug treatment of cervical dysplasia.
Release form and composition
Dosage form - vaginal suppositories: torpedo-shaped, from light to yellowish-pink color [5 or 10 pcs. in blisters made of PVC (polyvinyl chloride) film. In a cardboard box 2, 3, 5, 7 or 9 packs of 5 pcs. or from 2 to 10 packs of 10 pcs. Each pack contains instructions for the use of Cervikon-DIM].
One suppository contains:
- active ingredient: diindolylmethane - 100 mg;
- auxiliary components: witepsol brand N-15 (solid fat) - 1979.5 mg; Kollidone CL (crospovidone) - 20 mg; dye carmine red (E120) - 0.5 mg.
Pharmacological properties
Pharmacodynamics
The active ingredient of Cervikon-DIM is diindolylmethane, a stimulator of apoptosis of infected HPV (human papillomavirus) and transformed cells, increasing the rate of their excretion. In addition, it induces the expression of receptors for γ-interferon, thereby enhancing the nonspecific immune response to infection. The therapeutic effect of the drug is based on this.
Diindolylmethane also contributes to the normalization of estradiol metabolism in HPV-infected cells, which interferes with the synthesis of 16α-hydroxyestrone (a carcinogenic estrogen metabolite), which is responsible for the activation of the expression of HPV oncogenes. By inhibiting the expression of the HPV viral oncogene E7, Cervikon-DIM blocks the pathological hormone-dependent proliferation of infected cells.
Diindolylmethane is practically non-toxic, the half-lethal dose indicator (LD 50) for it is more than 5 g / kg.
Pharmacokinetics
Intravaginal application of diindolylmethane provides high local bioavailability, while the substance practically does not enter the systemic circulation.
Indications for use
Cervikon-DIM is recommended for the treatment of cervical intraepithelial neoplasia (dysplasia) of the cervix.
The drug is effective regardless of the results of detecting human papillomavirus infection by polymerase chain reaction (PCR diagnostics).
Contraindications
- pregnancy and the period of breastfeeding;
- children and adolescents under 18 years of age;
- individual hypersensitivity to any of the components in the suppository composition.
Cervikon-DIM, instructions for use: method and dosage
Suppositories Cervikon-DIM are intended for intravaginal administration.
Recommended dosing regimen: 1 suppository (100 mg diindolylmethane) 2 times a day. The duration of the therapeutic course is from 3 to 6 months.
The duration of treatment is determined by the attending physician based on the dynamics of the data of clinical and laboratory studies.
Recommendations for the route of administration:
- Suppositories are inserted into the vagina, 1 pc. 2 times a day, in the morning and in the evening.
- Wash your hands thoroughly immediately before the procedure.
- The procedure is required in the supine position; suppositories must be injected deep into the vagina.
- It is advisable to use a sanitary napkin after application.
Side effects
As a rule, Cervicon-DIM is well tolerated by patients.
The undesirable effects listed below can occur in some cases and are usually reversible [gradation of the frequency of occurrence of side effects according to the classification of the World Health Organization (WHO): often - not less than 1/100, but less than 1/10; infrequently - not less than 1/1000, but less than 1/100]:
- immune system: often - itching, urticaria;
- cardiac activity: infrequently - shortening of atrioventricular conduction;
- vessels: infrequently - an increase in blood pressure;
- gastrointestinal tract: infrequently - diarrhea;
- skin and subcutaneous fat: infrequently - retarded hair growth on the head and / or body, petechial rash on the skin;
- genitals and mammary gland: often - burning, itching, discomfort in the vagina, flocculent discharge and leucorrhoea from the genital tract; infrequently - delayed menstruation, increased vaginal dryness during sexual intercourse;
- data from laboratory and instrumental studies: often - an increase in the activity of the liver enzymes AST (aspartate aminotransferase) and ALT (alanine aminotransferase) in blood plasma, an increase in the erythrocyte sedimentation rate, thrombocytopenia, leukocyturia, proteinuria, bacteriuria, ketonuria; infrequently - a decrease in the level of creatinine in the blood plasma, vaginal dysbiosis, leukocytosis in the cervical smear, symptoms of myocardial hypoxia on the ECG (electrocardiogram).
The manifestation or aggravation of any of these adverse reactions or the development of other side effects not described in the instructions must be reported to the attending physician.
Overdose
Symptoms of an overdose of Cervicon-DIM are unknown.
special instructions
When treating vaginal infections, suppositories should not be used during menstruation; it is advisable to start the course at the end of menstrual bleeding.
It is recommended to abstain from sexual intercourse during treatment. If necessary, it is required to use reliable contraceptives.
Influence on the ability to drive vehicles and complex mechanisms
Cervikon-DIM therapy does not affect the performance of types of work requiring increased concentration of attention and speed of reactions, such as driving and other vehicles, performing the functions of a dispatcher or operator, etc.
Application during pregnancy and lactation
The use of Cervicon-DIM is contraindicated in pregnant and breastfeeding women.
Pediatric use
In pediatric practice, the drug is not used.
Drug interactions
Special studies on the interaction of diindolylmethane with other substances / preparations have not been carried out.
The drug is applied topically, its systemic pharmacokinetic effect can be neglected, therefore any interaction with drugs for systemic use can be excluded.
Suppositories Cervikon-DIM should not be used concurrently with other drugs for local intravaginal use that are part of the group of antiseptic-oxidizing agents, for example, potassium permanganate, iodine, hydrogen peroxide.
Analogs
The analogues of Cervikon-DIM are Terzhinan, Klion-D 100, Betadine, Metronidazole, Clindamycin 2%, Macmiror complex, Metrogyl, Clindacin, Bifidumbacterin, Tantum rose, etc.
Terms and conditions of storage
Store at temperatures from 2 to 8 ° C in a dark place. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Cervikon-DIM
Women who used the drug leave a lot of rather contradictory reviews about Cervicone-DIM. Some patients claim that the use of this gentle method of therapy helped them avoid surgery and allowed them to start preparing for pregnancy. Their complaints were caused only by the high cost of the drug, a long course and minor side effects in the form of discomfort due to the leakage of suppositories after application.
But many patients claim that the experience of using Cervikon-DIM suppositories turned out to be negative, in the absence of the expected therapeutic effect, they had to endure very strong allergic reactions in the form of itching and burning, which did not go away for a long time.
Price for Cervikon-DIM in pharmacies
The approximate price of Cervicon-DIM, vaginal suppositories, 100 mg, for a package containing 25 pcs., Can range from 1600 rubles.
Cervikon-DIM: prices in online pharmacies
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Drug name Price Pharmacy |
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Cervikon-Dim 100 mg vaginal suppositories 25 pcs. 1559 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
