Injectran
Injectran: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Iniectran
ATX code: M01AX25
Active ingredient: chondroitin sulfate (chondroitin sulfate)
Producer: LLC "Ellara" (Russia)
Description and photo update: 2018-27-11
Prices in pharmacies: from 977 rubles.
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Injectran is a drug that regulates metabolism in cartilage tissue, regenerating, chondrostimulating, analgesic and anti-inflammatory action.
Release form and composition
The drug is produced in the form of a solution for intramuscular (i / m) administration: a clear, colorless or yellowish liquid (1 or 2 ml in a glass ampoule: 5 or 10 ampoules complete with an ampoule scarifier in a cardboard box with a corrugated insert; 5 ampoules in a blister strip with or without aluminum foil, 1 or 2 packs complete with an ampoule scarifier in a cardboard box; if ampoules have a point or a break ring, the ampoule scarifier is not included in the kit; for hospital - 4, 5 or 10 blisters in cardboard box, 50 or 100 - in a cardboard box; each box also contains instructions for use of Injectran).
1 ml of solution contains:
- active substance: chondroitin sodium sulfate - 100 mg (in terms of dry matter);
- additional components: sodium hydroxide solution, sodium disulfite, water for injection, methyl parahydroxybenzoate.
Pharmacological properties
Pharmacodynamics
Injectran is a tissue repair stimulator. Chondroitin sulfate, the active ingredient of the drug, is the main component of proteoglycans, which, in combination with collagen fibers, make up the cartilage matrix. The active ingredient, with its chondroprotective properties, has the following effect:
- enhances metabolic processes in the tissues of fibrous and hyaline cartilage and subchondral bone;
- stimulates the synthesis of proteoglycans by cells of cartilage tissue (chondrocytes);
- inhibits the activity of enzymes leading to degradation (destruction) of articular cartilage;
- has a beneficial effect on phosphorus-calcium metabolism in the cartilage tissue, accelerates its regeneration;
- participates in the formation of the basic substance of cartilage and bone tissue.
Injectran exhibits anti-inflammatory and analgesic properties, helps to reduce the penetration of pain factors and inflammatory mediators into the synovial (filling the joint cavity) fluid through macrophages and synoviocytes enclosed in the synovial membrane, inhibits the production of leukotrienes (LT) and prostaglandins (PG).
Chondroitin sulfate inhibits the degeneration of connective tissue and lowers calcium loss, stimulates the processes of bone tissue repair, prevents the progression of osteoarthritis and osteochondrosis. The active substance is involved in the regeneration of the cartilaginous surfaces of the joints and the joint capsule, counteracts the development of collapse of the connective tissue, and ensures the normal production of joint fluid.
Thanks to the action of Injectran, the mobility of the joints improves and the intensity of pain decreases. After the completion of the course of treatment, the clinical effect of the drug persists for a long period. In the treatment of degenerative changes in the joints occurring with the development of secondary synovitis, the effect is achieved already 2-3 weeks after the start of the drug. Since the drug is structurally similar to heparin, it is potentially able to block the formation of fibrin thrombi in the synovial and subchondral microcircular bed.
Pharmacokinetics
When administered intramuscularly, the active substance is easily absorbed. 30 minutes after the i / m injection, the agent in significant concentrations is determined in the blood, and after 15 minutes it is detected in the synovial fluid. The maximum concentration (C max) of the drug in the blood plasma is observed 60 minutes after administration, and then, over 2 days, the level of its content gradually decreases. The substance accumulates mainly in the cartilage tissue, in the articular cartilage C max is observed after 48 hours. In the process of penetration of the agent into the joint cavity, it passes the synovium without obstacles. The drug is excreted mostly by the kidneys within 24 hours.
Indications for use
Injectran is recommended for the treatment of degenerative-dystrophic diseases of the joints and spine:
- osteoarthritis of the peripheral joints;
- intervertebral osteochondrosis and osteoarthritis.
Also, the drug is used for fractures in order to form callus.
Contraindications
- thrombophlebitis;
- bleeding, predisposition to bleeding;
- childhood;
- pregnancy and lactation;
- hypersensitivity to any of the constituents of the drug.
Injectran, instructions for use: method and dosage
Injectran injections are administered intramuscularly every other day, 1 ml (100 mg).
If the drug is well tolerated, starting from the fourth injection, the dose is increased to 2 ml (200 mg), the course of therapy is 25–35 injections. If necessary, 6 months after the end of the application of the drug, it is possible to prescribe a second course, the duration of which is determined by the attending physician individually.
In case of fractures for the formation of callus, the solution is injected every other day for 3-4 weeks (10-14 injections every other day).
Side effects
- skin and subcutaneous tissue: urticaria, itching, skin rash, erythema, dermatitis;
- immune system: angioedema, allergic reactions;
- digestive system: dyspeptic symptoms;
- local reactions: itching, redness, hemorrhages at the injection site.
The above violations can be observed mainly in persons with hypersensitivity to the components of the drug.
Overdose
Cases of Injectran overdose have not been recorded at the present time. If the drug is administered in daily doses that are higher than the recommended ones, an increase in the severity of its side effects may presumably be observed. In this condition, symptomatic treatment is indicated.
special instructions
For patients with gastric ulcer or duodenal ulcer, overweight, with concomitant treatment with diuretics, as well as at the beginning of the course, if it is necessary to achieve a clinical response as soon as possible, it is recommended to increase Injectran dosages under the supervision of the attending physician.
If hemorrhages or allergic reactions occur during therapy, the drug should be discontinued.
Influence on the ability to drive vehicles and complex mechanisms
When using Injectran in the recommended dosages, its effect on the speed of reactions and concentration of attention was not revealed. In the case of administration of high doses of the drug, care should be taken when driving vehicles and operating any complex, potentially dangerous machinery.
Application during pregnancy and lactation
It is contraindicated to use Inektran during pregnancy.
If it is necessary to use the drug during lactation, it is required to stop breastfeeding.
Pediatric use
In pediatric practice, Injectran injections are not used, since until now there is no information confirming the safety and effectiveness of chondroitin sulfate therapy in children.
Drug interactions
- glucosamine or other chondroprotectors: manifestations of synergistic effects may be noted;
- fibrinolytics, antiplatelet agents, indirect anticoagulants: there may be an increase in the effect of these funds, and therefore it is necessary to monitor blood coagulation indicators more often.
Analogs
Analogs of Inektran are: Artravir-Inkampharm, Chondroxide, Artogistan, Drastop, Artradol, Chondroguard, Mucosat, Chondroitin-AKOS, Chondroitin sulfate, Chondrolone.
Terms and conditions of storage
Store in a place protected from light, out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Injectran
The few reviews about Injectran on medical forums are mostly positive. Patients note that after the course of treatment with the drug, their well-being significantly improves, the intensity of pain in the spine and joints decreases, and the mobility of the latter also increases. According to reviews, a stable clinical effect of Injectran is noted throughout the year after the completion of the course of therapy. There are no complaints about the appearance of undesirable reactions.
Price for Injectran in pharmacies
The price for Inektran can be 1500-1700 rubles per package containing 10 ampoules of 2 ml solution for intramuscular injection (100 mg / ml).
Injectran: prices in online pharmacies
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Drug name Price Pharmacy |
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Inektran 100 mg / ml solution for intramuscular injection 2 ml 10 pcs. RUB 977 Buy |
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Injectran solution for intramuscular injection 100mg / ml amp. 2ml 10 pcs. 1416 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
