Triducard - Instructions For The Use Of Tablets, Analogues, Reviews, Price

Table of contents:

Triducard - Instructions For The Use Of Tablets, Analogues, Reviews, Price
Triducard - Instructions For The Use Of Tablets, Analogues, Reviews, Price

Video: Triducard - Instructions For The Use Of Tablets, Analogues, Reviews, Price

Video: Triducard - Instructions For The Use Of Tablets, Analogues, Reviews, Price
Video: I'm Quitting: Painful Truth About Drawing Tablet Reviews [Scribble Kibble #106] 2024, November
Anonim

Triducard

Triducard: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. For violations of liver function
  13. 13. Drug interactions
  14. 14. Analogs
  15. 15. Terms and conditions of storage
  16. 16. Terms of dispensing from pharmacies
  17. 17. Reviews
  18. 18. Price in pharmacies

Latin name: Triducard

ATX code: C01EB15

Active ingredient: Trimetazidine (Trimetazidine)

Manufacturer: CJSC Severnaya Zvezda (Russia)

Description and photo update: 2018-25-10

Prices in pharmacies: from 199 rubles.

Buy

Modified-release film-coated tablets, Triducard
Modified-release film-coated tablets, Triducard

Triducard is an antihypoxic agent with antianginal action.

Release form and composition

Dosage form Triducarda - modified release film-coated tablets: pink, round, biconvex (in a blister contour package 10 pcs., In a cardboard box 3 or 6 packs; in a blister contour packaging 30 pcs., In a cardboard box 1, 2, 3, 4, 6 or 10 packs; in a polymer can or bottle 30, 60, 90, 120, 180 or 300 pcs., In a cardboard box 1 can or bottle).

Composition of one tablet:

  • active substance: trimetazidine dihydrochloride - 35 mg;
  • auxiliary components (core): microcrystalline cellulose, hypromellose (methocel K 4M Premium EP), aerosil (colloidal silicon dioxide), magnesium stearate;
  • shell: hypromellose (hydroxypropyl methylcellulose), titanium dioxide, talc, macrogol (polyethylene oxide 4000), dye azorubin (E122) (acid red 2C for pharmaceuticals).

Pharmacological properties

Pharmacodynamics

Trimetazidine dihydrochloride, the active substance of Triducard, has antihypoxic and antianginal effects. By directly affecting the muscle cells of the heart (cardiomyocytes) and brain neurons, trimetazidine normalizes their metabolism and functioning. Increased energy potential, activation of the oxidative decarboxylation process and rationalization of oxygen consumption (by blocking fatty acid oxidation and enhancing the reactions of aerobic glycolysis) determine the cytoprotective effect of the drug.

Trimetazidine promotes myocardial contractility, prevents a decrease in the intracellular content of adenosine triphosphoric acid and phosphocreatinine. In acidosis, it improves the functioning of ion channels, prevents the accumulation of calcium and sodium in the muscle cells of the heart, and normalizes the intracellular concentration of potassium ions.

Due to the action of trimetazidine, the concentration of phosphates and the amount of intracellular acidosis, caused by reperfusion and myocardial ischemia, decrease.

In addition, the active substance suppresses the damaging effect of free radicals, helps to preserve the integrity of cell membranes, prevents the activation of neutrophils in the ischemic zone, reduces the release of the enzyme creatine phosphokinase from the cells and the severity of ischemic myocardial damage, and also increases the duration of the electric potential.

With angina pectoris, Triducard reduces the frequency of attacks (due to a decrease in nitrate consumption). Approximately 2 weeks after the start of treatment, blood pressure drops decrease, vestibular test results improve, exercise tolerance increases, hearing normalizes, tinnitus and dizziness decrease.

Trimetazidine helps to restore the functional activity of the retina in vascular diseases of the eyes.

Pharmacokinetics

  • absorption and distribution: after oral administration, trimetazidine dihydrochloride is rapidly and almost completely absorbed in the gastrointestinal tract; bioavailability - 90%. After a single dose of trimetazidine at a dose of 35 mg, the maximum plasma concentration is reached after 2 hours and is approximately 55 ng / ml. The substance easily penetrates the histohematogenous barriers. 16% of the drug binds to plasma proteins;
  • Excretion: the half-life (T 1/2) is 4.5–5 hours; excreted from the body by the kidneys (unchanged about 60%).

Indications for use

  • ischemic heart disease - for the prevention of angina attacks (in complex treatment);
  • dizziness due to vascular diseases;
  • chorioretinal vascular disorders;
  • cochleovestibular disorders of ischemic origin (including hearing impairment, tinnitus).

Contraindications

  • severe renal failure (creatinine clearance less than 15 ml / min);
  • severe liver failure;
  • age up to 18 years;
  • pregnancy and lactation period;
  • increased individual sensitivity to any component of the drug.

Instructions for use of Triducard: method and dosage

Triducard is taken orally during meals.

Recommended daily dosage: 2 tablets (70 mg) in 2 divided doses; the duration of the course of therapy is determined by the doctor.

Side effects

  • from the gastrointestinal tract: rarely - nausea, vomiting, pain in the stomach;
  • allergic reactions: itchy skin;
  • others: rarely - a feeling of a strong heartbeat, headache.

Overdose

There is no information on drug overdose at this time.

special instructions

Triducard is not intended for relieving angina attacks.

With the development of an attack of angina pectoris, it is necessary to revise and adapt therapy (revascularization and / or correction of treatment).

Influence on the ability to drive vehicles and complex mechanisms

Taking the drug does not affect the ability to perform work associated with the risk of accidents, including driving vehicles.

Application during pregnancy and lactation

According to the instructions, Triducard is contraindicated for use in women during pregnancy and breastfeeding.

Pediatric use

Since the efficacy and safety of the drug in pediatrics has not been established, it is not recommended to prescribe Triducard to children and adolescents under 18 years of age.

With impaired renal function

In patients with severe renal insufficiency (creatinine clearance less than 15 ml / min), the use of Triducard is contraindicated.

For violations of liver function

The drug should not be administered to patients with severe liver dysfunction.

Drug interactions

There is no data on drug interactions.

Analogs

Analogs of Triducard are: Antisten, Angiosil retard, Vero-Trimetazidin, Predizin, Trimectal MV, Deprenorm MV, Preductal MV, Trimetazidin MV, Trimetazidin-Teva, Rimecor, Trimitard MV and others.

Terms and conditions of storage

Store in a dark, dry place at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Triducard

Judging by the few reviews about Triducard, the drug is effective as a supportive therapy for cardiovascular diseases. The tablets take effect after a few days of regular use. In addition, they note that the drug has an acceptable cost.

Price for Triducard in pharmacies

The price for Triducard for one package is approximately: 30 tablets - from 88 to 128 rubles, 60 tablets - from 175 to 268 rubles.

Triducard: prices in online pharmacies

Drug name

Price

Pharmacy

Triducard 35 mg modified release film-coated tablets 60 pcs.

199 RUB

Buy

Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

Recommended: