Delorsine
Delorsin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Delorsin
ATX code: R06AX27
Active ingredient: desloratadine (Desloratadine)
Manufacturer: Saneka Pharmaceuticals a.s. (Saneca Pharmaceuticals, as) (Slovak Republic)
Description and photo update: 2020-14-07
Prices in pharmacies: from 181 rubles.
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Delorsin is an anti-allergic drug, blocker of H 1 -histamine receptors.
Release form and composition
Dosage form - tablets: round, biconvex, pink, on one side there is a risk (10 pieces in blisters, in a cardboard box of 1, 2, 3, 5, 6, 9 or 10 blisters and instructions for using Delorsin) …
Composition for 1 tablet:
- active substance: desloratadine - 5 mg;
- auxiliary ingredients: granulated microcrystalline cellulose (MKTs 102) - 89.45 mg; microcrystalline cellulose (MKTs 101) - 5 mg; sodium carboxymethyl starch (CMC), type A - 4.2 mg; magnesium stearate - 1.2 mg; dye iron oxide red (E172) - 0.15 mg.
Pharmacological properties
Pharmacodynamics
The active substance in the composition of Delorsin tablets is desloratadine, the primary active metabolite of loratadine. It has a long-term antihistamine effect on the body, due to a selective effect on peripheral H 1 -histamine receptors.
Desloratadine inhibits a cascade of allergic inflammatory reactions, including the release of cytokines that mobilize the inflammatory response [such as interleukins (IL) - IL-4, IL-6, IL-8, IL-13] and pro-inflammatory chemokines [for example, RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted)]. Inhibits the production of superoxide anions by activated polymorphonuclear neutrophils, chemotaxis and adhesion of eosinophils, the release of intercellular adhesion molecules (for example, P-selectin), immunoglobulin E (IgE) -mediated release of prostaglandin D 2, histamine and cysteine cysteine.
Delorsin prevents the development and facilitates the course of hypersensitivity reactions, providing antipruritic and antiexudative action, reducing capillary permeability, preventing the development of tissue edema and smooth muscle spasm.
The drug does not affect the central nervous system (CNS), has almost no sedative effect (does not cause drowsiness) and does not change the speed of psychomotor reactions. Taking desloratadine does not prolong the QT interval on the electrocardiogram (ECG).
Delorsin begins to act within half an hour after oral administration, the therapeutic effect is observed for 24 hours.
Pharmacokinetics
- absorption: after oral administration in the digestive tract, desloratadine is well absorbed; in blood plasma is determined after half an hour, C max (maximum concentration) on average reaches after 3 hours;
- distribution: desloratadine binds to plasma proteins at the level of 83–87%. Taking the drug for 2 weeks once a day at a dose of 5–20 mg in adult patients and adolescents did not cause clinically significant accumulation of desloratadine. The substance does not cross the blood-brain barrier (BBB). When Delorsin is taken once a day at a dose of 7.5 mg, its distribution is not affected by the simultaneous intake of food or grapefruit juice;
- Metabolism: The metabolic process takes place in the liver through hydroxylation, resulting in the formation of 3-OH-desloratadine combined with glucuronide. Desloratadine does not inhibit the cytochrome P 450 3A4 and 2D6 enzymes, nor is it an inhibitor or substrate of P-glycoprotein;
- excretion: a small part of the oral dose is excreted in the urine (less than 2%) and in the feces (less than 7%). T 1/2 (half-life) varies from 20 to 30 hours (an average of 27 hours).
Indications for use
Delorsin is used to treat seasonal or year-round allergic rhinitis with the aim of eliminating or relieving nasal congestion, sneezing, mucus discharge from the sinuses, itching in the nose and in the palate, lacrimation, itching and redness of the eyes.
It is also prescribed for urticaria to reduce or eliminate itching and rash.
Contraindications
Absolute:
- pregnancy and breastfeeding;
- children under 12 years old;
- established hypersensitivity to desloratadine, loratadine and any of the auxiliary components in the composition of the tablets.
With caution, Delorsin for allergies is recommended for use in severe renal failure and in patients with a history of seizures.
Delorsin, instructions for use: method and dosage
Delorsin tablets are intended for oral administration. They must be swallowed whole with water without chewing. It is advisable to take the drug regularly at the same time of day, regardless of food intake.
The recommended dosage regimen, unless the doctor has prescribed otherwise, for adolescents over 12 years of age and adult patients: once a day, 1 tablet (5 mg).
Duration of therapy:
- seasonal (intermittent) allergic rhinitis with the manifestation of symptoms no more than 4 days a week or less than 4 weeks a year (an assessment of the course of the disease is required): taking desloratadine in case of disappearance of symptoms is stopped, treatment should be resumed when they reappear;
- perennial (persistent) allergic rhinitis with symptoms lasting more than 4 days a week or more than 4 weeks a year: Delorsin continues to be taken throughout the entire period of exposure to the allergen.
If therapy does not help to improve the condition, the symptoms of the disease are aggravated or new symptoms appear, you should seek the advice of a specialist.
Delorsin should be used according to the indications, in accordance with the method of application and dosing regimen set out in the instructions.
Side effects
Most often (from ≥ 0.01 to <0.1), with a frequency slightly higher than in the placebo group, the following side effects were recorded when using desloratadine: headache - 0.6%; dry mouth - 0.8%; increased fatigue - 1.2%.
In adolescents from 12 to 17 years old, the most common adverse reaction according to the results of clinical trials was headache - 5.9%, while its frequency with placebo was 6.9%.
In accordance with the requirements of the World Health Organization (WHO), the classification of side effects is determined by the frequency of their development according to the following scale: very often (≥ 0.1); often (from ≥ 0.01 to <0.1); infrequently (from ≥ 0.001 to <0.01); rarely (from ≥ 0.0001 to <0.001); extremely rare (<0.0001); with an unknown frequency (it is not possible to establish the frequency of side effects from the available data).
Adverse reactions of Delorsin from systems and organs, registered during clinical trials and in the post-registration period:
- CNS: often - headache; extremely rarely - drowsiness, insomnia, dizziness, psychomotor agitation, convulsions;
- psyche: extremely rare - hallucinations;
- hepatobiliary system: extremely rarely - an increase in the activity of liver enzymes, an increase in the concentration of bilirubin, hepatitis; with an unknown frequency - jaundice;
- gastrointestinal tract (GIT): often - dry mouth; extremely rare - nausea, vomiting, abdominal pain, dyspepsia, diarrhea;
- cardiovascular system: extremely rare - palpitations, tachycardia; with an unknown frequency - lengthening of the QT interval;
- musculoskeletal system: extremely rare - myalgia;
- skin and subcutaneous tissues: with unknown frequency - photosensitization;
- metabolism and nutrition: with an unknown frequency - an increase in body weight, increased appetite;
- general disorders: often - increased fatigue; extremely rarely - shortness of breath, angioedema, anaphylaxis, itching, rash, including urticaria; with an unknown frequency - asthenia.
In the post-registration period, children and adolescents over 12 years of age when taking Delorsin with an unknown frequency were observed arrhythmia, lengthening of the QT interval, bradycardia.
In case of aggravation of any of the above side effects or the development of other reactions not listed in the instructions, you should consult a doctor.
Overdose
The symptoms of a desloratadine overdose have not been reliably established. Taking the drug in a dose that was 5 times higher than the recommended dose did not lead to any symptoms. During clinical trials with daily intake of desloratadine for 2 weeks at a dose of up to 20 mg in adolescents and adult patients, statistically or clinically significant changes in the cardiovascular system were not observed. In the course of a clinical and pharmacological study of 10-day use of desloratadine at a dose 9 times higher than the recommended and amounting to 45 mg per day, no prolongation of the QT interval was recorded and no other serious side effects were identified.
In case of unintentional ingestion of Delorsin in high doses and suspicion of intoxication, you should immediately consult a doctor. As soon as possible after oral administration of the drug, it is recommended to rinse the stomach and take activated charcoal, after which, if necessary, carry out symptomatic therapy.
Desloratadine is not excreted during hemodialysis. Also, the effectiveness of peritoneal dialysis for its removal has not been established.
special instructions
The study of the effectiveness of Delorsin for the treatment of rhinitis of infectious etiology has not been conducted.
Patients with a history of seizures, especially patients under 18 years of age, should use desloratadine with caution. When seizures develop, Delorsin should be discontinued.
Influence on the ability to drive vehicles and complex mechanisms
During therapy, it is important to take into account the likelihood of developing such negative side reactions as drowsiness and dizziness. When they appear, one should refrain from performing activities that require an increased concentration of attention and speed of psychomotor reactions, including driving vehicles or controlling complex mechanisms.
Application during pregnancy and lactation
It is contraindicated to use Delorsin for allergies to pregnant women, since there are no data from clinical studies of the safety of its use in women during gestation.
Desloratadine passes into breast milk, and therefore it is contraindicated to use the drug during breastfeeding.
Pediatric use
In pediatric practice, Delorsin tablets are not prescribed for the treatment of children under 12 years of age.
With impaired renal function
When treating patients with severe renal failure, Delorsin should be used with caution.
Drug interactions
Azithromycin, ketoconazole, fluoxetine, cimetidine, erythromycin, when used together with desloratadine, do not show clinically significant pharmacological interactions.
The effectiveness of Delorsin is not affected by the simultaneous administration of the drug with food or grapefruit juice.
Desloratadine does not aggravate the effect of ethanol on the central nervous system, but during post-registration use, there have been reports of cases of incompatibility of Delorsin with alcohol. During therapy, it is recommended to be careful when drinking alcoholic beverages.
Analogs
Delorsin's analogs are Alestamine, Blogir-3, Desloratadin, Desal, Desloratadin Velpharm, Desloratadin-VERTEX, Desloratadin Canon, Desloratadin-Teva, Nalorius, Lordestin, Ezlor, Ezlor Solution Tabletts, Erius, Elisey and dr.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Delorsine
Almost all patients leave positive reviews about Delorsin. The drug is inexpensive, of excellent quality, provides a fast, stable and long-lasting result after administration. A modern antihistamine does not cause drowsiness in most allergy sufferers, therefore it is suitable for drivers.
Delorsin helps with contact allergies, copes well during the flowering season, eliminates nasal swelling and itching, is well tolerated. There are no complaints about adverse reactions.
The price of Delorsin in pharmacies
Estimated price of Delorsin, 5 mg tablets, 30 pcs per pack. - 298 rubles; per package 10 pcs. - 171 rubles.
Delorsin: prices in online pharmacies
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Drug name Price Pharmacy |
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Delorsin tablets 5mg 10pcs RUB 181 Buy |
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Delorsin tablets 5mg 30pcs 328 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
