Proneiro - Instructions For Use, Reviews, Price, Injections, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Proneiro

Proneiro: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Use in the elderly
12. 12. Drug interactions
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Terms of dispensing from pharmacies
16. 16. Reviews
17. 17. Price in pharmacies

Latin name: Proneuro

ATX code: N06BX06

Active ingredient: citicoline (Citicoline)

Manufacturer: PJSC "Galichpharm" (Ukraine)

Description and photo update: 2019-28-11

Prices in pharmacies: from 509 rubles.

Buy

Proneiro is a medicinal product for oral and parenteral administration of nootropic action.

Release form and composition

Proneiro is available in the following dosage forms:

• oral solution: a colorless liquid, sometimes with a slight yellowish tinge, with a specific odor; a slight opalescence may appear during storage of the solution, which disappears after keeping the drug at a temperature of about 20 ° C (45 ml each in dark glass vials sealed with polyethylene lids, in a cardboard box 1 bottle complete with a syringe-dispenser and instructions for medical use);
• solution for intravenous and intramuscular administration: colorless, transparent liquid (4 ml each in colorless glass ampoules with a yellow break ring for a dosage of 125 mg / ml or a red break ring for a dosage of 250 mg / ml; 5 ampoules in blisters, in a cardboard box 2 blister complete with instructions for use of Proneiro).

Composition for 1 ml of oral solution:

• active substance: citicoline (in the form of sodium citicoline) - 100 mg;
• auxiliary components: glycerol, sodium saccharinate, potassium sorbate, propyl parahydroxybenzoate, sorbitol, glycerol formal, methyl parahydroxybenzoate, sodium citrate, citric acid monohydrate, water.

Composition for 1 ml of solution for intravenous and intramuscular administration:

• active substance: citicoline (in the form of sodium citicoline) - 125 mg or 250 mg;
• auxiliary components: sodium hydroxide solution or hydrochloric acid solution (to obtain a pH of 6.5–7.1), water for injection.

Pharmacological properties

Pharmacodynamics

Citicoline is a precursor of important structural components of the cell membrane (mainly phospholipids), therefore its spectrum of action is very wide. It inhibits phospholipases, preventing excess accumulation of free radicals; promotes the restoration of damaged cell membranes; affects the mechanisms of apoptosis, preventing premature cell death.

Proneiro reduces the volume of brain tissue damage in the acute phase of stroke, and also improves the transmission of impulses in cholinergic synapses.

In patients with traumatic brain injuries, Proneiro reduces the duration of post-traumatic coma and reduces the severity of neurological symptoms, which contributes to faster recovery.

In persons with chronic hypoxia of the brain, the drug is effective in treating cognitive disorders: lack of initiative, memory impairment, difficulties arising in self-care and performing daily regular activities. Citicoline reduces the manifestations of amnesia and increases the level of consciousness and attention.

Proneiro is effective in motor and sensory neurological disorders of vascular and degenerative origin.

Pharmacokinetics

Citicoline is well absorbed both after oral administration and after intravenous administration and intramuscular Proneiro injections. Bioavailability is high and approximately the same for various applications.

The drug undergoes intestinal and hepatic metabolism, resulting in the formation of cytidine and choline.

The substance is distributed mainly in the structures of the brain. In this case, the cytidine fractions are incorporated into nucleic acids and cytidine nucleotides, and the choline fractions - into structural phospholipids. Thus, after penetration into the brain, citicoline is actively incorporated into the cytoplasmic, cellular and mitochondrial membranes, where it becomes part of the structural phospholipid fraction.

No more than 15% of the accepted or administered dose of citicoline is excreted from the body: about 12% with exhaled carbon dioxide and about 3% through the intestines and kidneys.

With urine, the drug is excreted in 2 phases: the first phase lasts about 36 hours (during the first phase, the rate of citicoline excretion decreases rapidly); in the second phase, the rate of citicoline elimination decreases very slowly. The same effect is observed during excretion with carbon dioxide: in the first 15 hours, the rate of excretion decreases rapidly, and then it decreases much more slowly.

Indications for use

• acute phase of ischemic stroke (as part of complex treatment);
• acute and recovery periods after traumatic brain injury;
• the recovery period after hemorrhagic and ischemic strokes;
• behavioral and cognitive disorders in vascular and degenerative diseases of the brain.

Contraindications

Absolute:

• severe vagotonia (the predominance of the tone of the parasympathetic part of the autonomic nervous system over the tone of its sympathetic part);
• period of breastfeeding;
• children and adolescents up to 18 years old;
• increased individual sensitivity to individual components of the drug.

During pregnancy, Proneiro is not recommended for use, except in cases where the benefits to the mother are significantly higher than the possible risk to the fetus.

Proneiro, instructions for use: method and dosage

Oral solution

Proneiro oral solution is intended for oral administration.

The drug is taken between meals or with meals. The recommended dose of the solution before use can be diluted in 120 ml of water.

In the acute period of traumatic brain injury and ischemic stroke, the recommended dosage is 10 ml of solution (1000 mg) twice a day (every 12 hours). The duration of therapy should be at least 6 weeks.

For accurate dosing of the drug, you must use the supplied dispenser After each use, it should be thoroughly rinsed with water.

In the recovery period after traumatic brain injury, hemorrhagic and ischemic strokes, as well as in behavioral and cognitive disorders, it is recommended to take 5-10 ml of solution (500-1000 mg) once or twice a day. The exact dosage of Proneiro and the duration of the course of treatment depend on the severity of the symptoms.

Solution for intravenous and intramuscular administration

Proneiro in the form of a solution for injection is injected intramuscularly (intramuscularly) or intravenously (intravenously).

The intravenous drug is prescribed in the form of a slow drip intravenous infusion at a rate of 40–60 drops per minute or intravenous injection, which, depending on the prescribed dose, is administered over 3–5 minutes.

Intravenous administration is preferred over intramuscular injection. If Proneiro's injections are given intramuscularly, it is advisable to avoid repeated administration of the solution in the same place.

In the acute period of traumatic brain injury and ischemic stroke, the drug is administered at a dose of 1000 mg every 12 hours. Treatment begins from the first day after diagnosis and continues for at least 6 weeks. If the swallowing function is not impaired, then after 3-5 days of treatment, the patient is transferred to the oral form of Proneiro.

In the recovery period after traumatic brain injury, hemorrhagic and ischemic strokes, as well as in behavioral and cognitive disorders, it is recommended to administer 500–2000 mg of the drug per day (in 1–2 injections). The exact dose and duration of treatment is determined by the doctor. Oral citicoline is acceptable.

In case of suspicion of ongoing intracranial bleeding, the dose of Proneiro should not exceed 1000 mg per day (it is recommended to intravenously drip the drug at a rate of 30 drops per minute).

Solution ampoules are intended for single use. The contents of the ampoule must be used immediately after opening.

Proneiro is compatible with dextrose solutions and other types of intravenous isotonic solutions.

Side effects

In very rare and isolated cases during the treatment of Proneiro, the following side effects occurred: headache, nausea, dizziness, vomiting, hallucinations, tremors, decreased appetite, changes in the activity of liver enzymes, a feeling of heat, shortness of breath, agitation, numbness in paralyzed limbs, diarrhea, edema, insomnia, allergic reactions (itching, skin rash, anaphylactic shock).

Sometimes there was a short-term change in blood pressure, as well as stimulation of the parasympathetic nervous system.

Overdose

Proneiro has low toxicity, so overdose is unlikely.

In case of accidental overdose, palliative treatment is recommended.

special instructions

Do not exceed a dose of 1000 mg per day if there is a suspicion of ongoing intracranial bleeding.

Influence on the ability to drive vehicles and complex mechanisms

During treatment, patients should be careful when working with potentially dangerous and complex mechanisms (for example, when driving a car or other transport, when performing the work of an operator, dispatcher, etc.).

Application during pregnancy and lactation

There is a lack of data on the use of Proneiro in pregnant women. Despite the fact that animal studies have not revealed a negative effect on the growth and development of the fetus, citicoline is not recommended for use during pregnancy (unless the benefits to the mother are significantly higher than the possible risk to the fetus).

There are no data on the penetration of citicoline into breast milk, therefore, if it is necessary to use Proneiro during lactation, breastfeeding should be discontinued.

Pediatric use

Proneiro is not used in children and adolescents under 18 years of age, since there is not enough data on its safety and effectiveness in this age group.

Use in the elderly

For elderly patients, Proneiro is prescribed in usual doses (no dosage adjustment is required).

Drug interactions

When used simultaneously with levodopa, citicoline enhances its effect.

It is not recommended to prescribe Proneiro in conjunction with drugs containing meclofenoxate.

Analogs

The analogues of Proneiro are Lexuver, Neuropol, Nootsil, Quinel, Neipilept, Neurocholine, Ronocyte, Recognan, Ceralin-Lekpharm, Citicolin, Cerakson, Ceresil Canon, Encetron-SOLOpharm, etc.

Terms and conditions of storage

Store in original packaging in a dark place out of the reach of children at a temperature of + 8 … + 30 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Proneiro

There are very few reviews of Proneiro, however, you can often find reviews of similar medicines, the active ingredient of which is citicoline. Citicoline drugs help repair areas of the brain damaged by a stroke; improve memory, thinking processes and the emotional sphere. They act gently, without exciting or depressing the central nervous system. Sometimes neurologists, despite the contraindication, prescribe these drugs in childhood, as they stimulate speech and help the child to speak.

The main disadvantage is the high cost of such drugs. In addition, they can cause side effects. Do not prescribe drugs with citicoline on your own, especially for children.

Price for Proneiro in pharmacies

The drug in the form of a solution for oral administration of 100 mg / ml (in bottles of 45 ml) can be purchased for 515–550 rubles.

The price of Proneiro in the form of a solution for intravenous and intramuscular administration with a dosage of 125 mg / ml (10 ampoules per pack) is 500–690 rubles, with a dosage of 250 mg / ml (10 ampoules per pack) - 930–990 rubles.

Proneiro: prices in online pharmacies

Drug name Price Pharmacy

Proneiro 100 mg / ml oral solution 45 ml 1 pc. 509 RUB Buy

Proneiro 125 mg / ml solution for intravenous and intramuscular administration 4 ml 10 pcs. 757 r Buy

Proneiro 250 mg / ml solution for intravenous and intramuscular administration 4 ml 10 pcs. RUB 830 Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!