Delagil
Delagil: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Delagil
ATX code: P01BA01
Active ingredient: Chloroquine (Chloroquinum)
Producer: Alkaloid Chemical Company ZAO for IC-En Polfa Rzeszow AO, Hungary / Poland
Description and photo update: 2019-12-08
Delagil is an antiprotozoal drug with immunosuppressive and anti-inflammatory action.
Release form and composition
Dosage form Delagil - tablets: flat form with a beveled edge, white or almost white, odorless (10 pcs. In blisters, in a cardboard box of 3 blisters).
The active ingredient is chloroquine (in the form of phosphate), 1 tablet contains 250 mg.
Excipients: polyacrylic acid (carbomer 934R), colloidal hydrophobic silicon dioxide (Aerosil R972), corn starch, magnesium stearate, polyvinyl butyral (Movital B30T), talc.
Pharmacological properties
Pharmacodynamics
Delagil is an antiprotozoal agent that also has anti-inflammatory and immunosuppressive effects. Its use leads to the destruction of asexual erythrocytic forms of all varieties of plasmodia. Delagil has a gametocidal effect, excluding Plasmodium falciparum (characterized by an anti-gametocidal effect).
Pharmacokinetics
After oral administration, chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract. The maximum level of this substance in the blood is observed 2-6 hours after ingestion. Chloroquine binds to plasma proteins (mainly albumin) by 55% and rapidly spreads through organ systems and body tissues (lungs, spleen, liver, kidneys).
The active component of Delagil freely penetrates the blood-brain barrier and into the placenta. Chloroquine is metabolized slightly (no more than 25%). It is slowly excreted through the kidneys (up to 70% of the dose taken - unchanged). The half-life is 1-2 months. With renal failure, the accumulation of chloroquine is possible.
Indications for use
- Prevention and treatment of all types of malaria;
- Subacute and chronic form of systemic lupus erythematosus;
- Extraintestinal amebiasis;
- Rheumatoid arthritis;
- Photodermatosis;
- Amebic liver abscess;
- Scleroderma.
Contraindications
- Hepatic and / or renal failure;
- Severe rhythm disturbances;
- Oppression of bone marrow hematopoiesis;
- Neutropenia;
- Psoriatic arthritis;
- Porphyrinuria;
- The period of pregnancy and breastfeeding;
- Hypersensitivity to drug components.
According to the instructions, Delagil should be used with caution in the treatment of patients with epilepsy, retinopathy, glucose-6-phosphate dehydrogenase deficiency.
Instructions for the use of Delagil: method and dosage
Delagil tablets are taken orally.
The following dosage is recommended depending on the clinical indication:
- Malaria treatment: 1st day - 4 tablets once, then after 6-8 hours - 2 pcs., On the 2nd and 3rd days of therapy, 3 pcs. Once a day;
- Prevention of malaria: 2 tablets 2 times in the first week, then - 2 pcs. every 7 days;
- Systemic lupus erythematosus: 1-2 tablets per day;
- Amoebiasis: 7 days - 2 tablets 3 times a day, then 7 days - 1 pc. 3 times a day, then within 2-6 months - 3 pcs. Two times per week;
- Rheumatoid arthritis: 2 tablets 2 times a day for 7 days, then 2 tablets. Once a day throughout the year;
- Photodermatosis: 1 tablet 1 time per day for 7 days, then 2-3 pcs. in Week.
Side effects
The use of Delagil can cause side effects:
- From the side of the cardiovascular system: lowering blood pressure, myocardial damage with changes in the electrocardiogram;
- From the digestive system: nausea, gastralgia, vomiting;
- From the senses: in case of prolonged use - ringing in the ears, corneal opacity, visual impairment, retinal damage;
- From the nervous system: sleep disturbances, dizziness, psychosis, headache, epileptic seizures;
- Allergic reactions: photosensitivity, dermatitis;
- Others: leukopenia, myalgia, discoloration of hair and skin.
Overdose
An overdose with Delagil can be determined by symptoms such as visual impairment, fainting, convulsions, collapse, depression of the respiratory center up to death (within 2 hours from the moment of respiratory depression).
As a therapeutic measure, it is necessary to induce vomiting, rinse the stomach and take activated charcoal inside in a dose 5 times higher than the amount of chloroquine taken. Plasmapheresis and peritoneal dialysis are also indicated.
special instructions
Treatment with Delagil should be accompanied by regular general blood tests and eye examinations.
Drug interactions
The combined use of the drug in combination with other antimalarial drugs can cause opposite effects.
With simultaneous use with Delagil:
- Gold preparations, phenylbutazone, penicillamine, levamisole, cytostatics - increase the likelihood of skin damage and bone marrow aplasia;
- Glucocorticosteroids (GCS) - increase the risk of developing cardiomyopathy and myopathy;
- Cardiac glycosides - increase glycosidic intoxication;
- Ethanol - increases hepatotoxicity;
- Monoamine oxidase (MAO) inhibitors - increase the risk of neurotoxicity;
- Cimetidine - increases the concentration of the drug in the blood;
- Antacids - interfere with the absorption of chloroquine.
Analogs
Delagil's analogues are: Immard, Plaquenil.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Delagil
Numerous reviews of Delagil confirm its average effectiveness. Many patients claim that their treatment negatively affects their vision. However, some patients like the cheapness of the pills.
The price of Delagil in pharmacies
The approximate price for Delagil in pharmacies is 183-266 rubles (a pack consists of 30 tablets).
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
