Besalol
Besalol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Besalol
ATX code: A03ED
Active ingredient: belladonna leaves extract (Belladonna folia extract) + phenylsalicylate (Phenylsalicylate)
Manufacturer: Tatkhimfarmpreparaty, JSC (Russia); Pharmaceutical company "Health" (Ukraine)
Description and photo update: 2019-09-09
Prices in pharmacies: from 51 rubles.
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Besalol is a combined preparation with antispasmodic and antiseptic effects, used in the treatment of diseases of the gastrointestinal tract.
Release form and composition
The drug is produced in the form of tablets (6 pcs. In contoured non-cell packs, in a cardboard box of 2, 3 or 5 packs and instructions for the use of Besalol).
Active ingredients in 1 tablet: belladonna extract - 10 mg, salol (phenyl salicylate) - 300 mg.
Pharmacological properties
Pharmacodynamics
The combined composition of Besalol provides its anti-inflammatory, antispasmodic, antiseptic and hyposecretory efficacy. Thanks to the latter, the drug inhibits the secretion of the glands: pancreas, stomach, salivary, bronchial and sweat, and also reduces the secretion of bile.
Properties of the active components of the drug:
- Belladonna (belladonna) leaf extract: a herbal ingredient that has m-anticholinergic and antispasmodic effects, inhibits the stimulating effect of acetylcholine, inhibits the secretory activity of the body. Belladonna alkaloids reduce the muscle tone of the gastrointestinal tract (gastrointestinal tract), gallbladder and ducts, but stimulate the tone of the sphincters. They cause tachycardia, increase atrioventricular (AV) conductivity, dilate the pupils, hindering the outflow of intraocular fluid, increase intraocular pressure and can cause accommodation paralysis;
- Phenyl salicylate: antiseptic, releases salicylic acid and phenol through hydrolysis in the alkaline contents of the intestine. Phenol is active against pathogenic intestinal microflora, salicylic acid has anti-inflammatory and antipyretic effects.
Pharmacokinetics
When taken orally, Besalol phenyl salicylate is not affected by the acidic environment of gastric juice, it is hydrolyzed to phenol and salicylic acid in the alkaline environment of the intestine.
Phenol is excreted in the urine, creating high concentrations in the urinary tract. Salicylic acid is biotransformed mainly in the liver, forms 4 metabolites found in many tissues of the body and urine. It is excreted mainly by active secretion in the renal tubules, up to 60% as unchanged salicylic acid, the rest in the form of its metabolites. The excretion of unchanged salicylate is in direct proportion to the acidity (pH) of urine, when alkalizing increases the ionization of salicylates, decreases their reabsorption and significantly increases excretion. The rate of excretion also depends on the dose taken: for low doses, the half-life is 2-3 hours, and with their increase it can increase to 15-30 hours.
The pharmacokinetic properties of belladonna leaf extract have not been studied.
Indications for use
Besalol tablets are prescribed for the treatment of diseases of the gastrointestinal tract, which are accompanied by intestinal dysbiosis and spasms of the smooth muscles of the abdominal organs.
Contraindications
- Prostate adenoma;
- Closed-angle glaucoma;
- Gastrointestinal bleeding;
- CRF (chronic renal failure);
- Children and adolescents under the age of 18;
- Hypersensitivity to the components included in the tablets.
Besalol, instructions for use: method and dosage
For adults, Besalol tablets are prescribed orally 2-3 times a day, 1 pc.
The duration of the drug is determined by the doctor individually.
Side effects
Usually the drug is well tolerated, sometimes the following side effects may develop:
- Allergic reactions;
- Dry mouth;
- Constipation;
- Delay in urination;
- Feeling of heartbeat;
- Dilation of the pupils;
- Paresis of accommodation;
- Increased intraocular pressure;
- Dizziness.
If these or other atypical symptoms occur, you should stop using Besalol and consult a doctor.
Overdose
Overdose symptoms may include: mydriasis, disturbance of accommodation, increase in intraocular pressure, intestinal atony, dysphagia, difficulty urinating (including acute urinary retention), thirst, dry skin / mucous membranes, headache, dizziness, tachycardia, delirium, psychomotor agitation …
In case of overdose, it is recommended to immediately stop taking the drug and, if necessary, carry out symptomatic treatment.
Antidotes for Besalol are cholinesterase inhibitors (neostigmine methyl sulfate, physostigmine).
special instructions
Patients for whom increased visual acuity is important should avoid the use of Besalol.
In diseases of the cardiovascular system, accompanied by bradycardia, it is permissible to use the drug only under the supervision of a doctor.
When conducting tests to determine the acidity of the stomach and the study of gastric emptying, it must be borne in mind that alkaloids of the extract of belladonna leaves can influence the results of laboratory tests.
Influence on the ability to drive vehicles and complex mechanisms
During therapy, care should be taken when performing types of work that require a high speed of psychomotor reactions, increased concentration of attention and increased visual acuity (including driving vehicles).
Application during pregnancy and lactation
The drug is not prescribed to pregnant women, since the safety of using Besalol during this period has not been established.
If, for health reasons, it is necessary to prescribe Besalol during lactation, breastfeeding must be stopped.
Pediatric use
Besalol is not used to treat children and adolescents under the age of 18.
With impaired renal function
It is contraindicated to take Besalol in patients with chronic renal failure.
Drug interactions
- Other m-anticholinergics: enhance the pharmacological effect of belladonna leaf extract;
- M-cholinomimetics, cholinesterase inhibitors: weaken the effectiveness of belladonna leaf extract;
- Antacids and antidiarrheal drugs: can reduce the absorption of active substances that make up Besalol;
- Other drugs: it is possible to change their absorption as a result of inhibition of intestinal motility under the action of belladonna leaf extract.
Analogs
Besalol's analogues are Gastroguttal, Rectobelol, Betiol, Xymelin Extra, Bellacehol, Bellastezin, Otrivin Complex, Bellavamen, Anusol, Bekarbon.
Terms and conditions of storage
Store in a dark, dry place at a temperature of 8-15 ° C. Keep out of the reach of children.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Besalol
The drug has been on the pharmaceutical market for many years and has proven itself in the best possible way. Almost all the reviews about Besalol are positive, the drug is non-prescription, inexpensive, it helps well with stomach pains, relieves them quickly and effectively. There are practically no reports of side effects.
The most common complaints are that the drug is not on sale.
Price for Besalol in pharmacies
The approximate price of Besalol is 93 rubles. per pack containing 10 tablets.
Besalol: prices in online pharmacies
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Drug name Price Pharmacy |
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Besalol tablets 6 pcs. RUB 51 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
