Trigrim
Instructions for use:
- 1. Release form, composition and packaging
- 2. Pharmacological action
- 3. Indications for use
- 4. Contraindications
- 5. Method of administration and dosage regimen
- 6. Overdose
- 7. Drug interactions
- 8. Side effects
- 9. Terms and conditions of storage
- 10. Special instructions
Prices in online pharmacies:
from 222 rub.
Buy
Trigrim is a diuretic.
Release form, composition and packaging
The instructions for Trigrim say that this drug is produced in the form of round, biconvex white tablets. 1 tablet contains 2.5 mg of torasemide. Additional substances include corn starch, magnesium stearate, lactose, colloidal silicon dioxide.
Trigrim is also made in the form of white, round, flat tablets, which have a long risk in the center. 1 tablet contains 5 mg or 10 mg of torasemide. Additional components include corn starch, magnesium stearate, lactose, colloidal silicon dioxide.
In pharmacies, it is sold in the form of blisters of 10 pcs.
Pharmacological action of Trigrim
The instruction to Trigrim shows that the analyzed drug and Trigrim analogs belong to the group of diuretic drugs. The principle of operation of the tablets is explained by the combination of torasemide with the Na + / 2Cl- / K + counterporter, which is located in the apical membrane of the thick segment of the ascending loop of Henle. That is why we can say that in the human body it significantly decreases or almost completely slows down, and the reabsorption of sodium ions is also prevented. The result of this process is a decrease in the osmotic pressure of the intracellular fluid, as well as the reabsorption of water.
In the responses to Trigrim, it was noted that the drug, due to its anti-aldosterone action, which is much less pronounced than that of furosemide, practically does not provoke hypokalemia, despite the high activity of its components and prolonged action.
Indications for Trigrim's use
- Edema associated with kidney, liver, heart disease;
- Arterial hypertension of the first degree.
Contraindications
Anuria, arrhythmia, pregnancy and lactation, chronic renal failure, as well as hypersensitivity to the individual components of Trigrim.
Patients with diabetes mellitus, liver diseases, gout require additional consultation.
Dosing and administration of Trigrim
The instructions for Trigrim say that this drug, as well as Trigrim analogs, are taken orally. Trigrim is prescribed for adults. It is allowed to take the tablets before or during meals.
If the patient has edema, then in such a case, the drug is prescribed at 5 mg no more than 1 time per day. If necessary, the dosage can be increased to 20 mg (this should be done gradually) once a day. In some cases, Trigrim should be taken up to 40 mg within 24 hours.
If a patient has edema, the cause of which is associated with congestive heart failure, then a specialist prescribes for such a patient from 5 to 20 mg of the drug per day. As stated in the instructions for Trigrim, under the supervision of a healthcare professional, the dosage can be gradually increased to a maximum of 200 mg.
For edema, the cause of which is associated with chronic renal failure, first of all, 20 mg of the analyte is prescribed per day. If there is an urgent need, the dosage is gradually increased (no more than 200 mg within 24 hours). This is done to achieve the best diuretic effect.
With edema, which are directly related to cirrhosis of the liver, the patient is prescribed a daily dose of 5-10 mg. In some cases, this dosage can be doubled (this should be done gradually), which allows you to achieve the best diuretic effect. Until now, there have been no medical studies that would tell about the possible consequences that arise in patients taking more than 40 mg of the drug for liver diseases.
If the patient has primary arterial hypertension, he is prescribed 2.5 mg of the drug per day. By increasing the dose to 5 mg, blood pressure remains unchanged. The maximum effect of the course of treatment occurs only after 12 weeks.
In the responses to Trigrim, it was noted that elderly patients do not need additional advice about the dosage and analogues of Trigrim.
Overdose
- Increased diuresis, which entails hypovolemia, electrolyte imbalance;
- Decreased blood pressure, drowsiness;
- Clouding of consciousness;
- Collapse;
- Malfunctions of the gastrointestinal tract.
The most effective method of treatment is to reduce the dosage or completely cancel the drug for each individual patient. Today there is no special antidote.
Trigrim drug interactions
When Trigrim is taken, the perception of the myocardium to cardiac glycosides increases significantly, if the body lacks calcium and potassium. If you take Trigrim or Trigrim analogues together with laxatives or glucocorticoids, then the process of excretion of potassium from the body may increase.
When used with antihypertensive drugs, the analyzed drug enhances their effect on the body. When Trigrim is taken in a high dosage, the toxic manifestations of a number of drugs (cisplatin, antibiotics) may increase.
Taking salicylates in higher dosages, there is an increase in their toxic interaction on the body. The effects of antidiabetic drugs become weaker, as do some vasoconstrictors (eg, norepinephrine and epinephrine).
NSAIDs in some cases reduce the hypotensive and diuretic effects of Trigrim. The action of cholestyramine sometimes provokes a decrease in the absorption of torasemide from the digestive system (this is confirmed by numerous experiments conducted on animals).
Side effects of Trigrim
In the responses to Trigrim, it is noted that among the most common side effects after taking this drug, there is a decrease in the concentration of leukocytes, erythrocytes and platelets.
In some cases, there is an increase in the serum of uric acid, lipids and even glucose. Hypokalemia may also occur. Very rarely there are failures in normal blood circulation, blood pressure is disturbed.
Reviews to Trigrim show that there are often problems with the work of the gastrointestinal tract, decreased appetite, as well as discomfort in the oral cavity. Quite rarely - pancreatitis and an increase in the activity of liver enzymes, urinary retention, as well as an increase in the concentration of creatinine and urea in plasma.
There are also frequent severe headaches, weakness, dizziness, confusion, drowsiness, cramps in the arms and legs, impaired hearing, vision, as well as complete deafness, itching and skin rashes.
Terms and conditions of storage of Trigrim
Keep out of reach of children at 25 degrees. Shelf life is not more than 3 years.
special instructions
Due to a lack of proper experimentation, it is not recommended to give Trigrim to children under 18 years of age. With long-term use of the drug, an examination of the body should be carried out regarding the level of glucose, lipids and uric acid. In the presence of hypokalemia, hypovolemia, Trigrim should be taken only after the symptoms of the listed diseases are completely eliminated.
Trigrim: prices in online pharmacies
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Drug name Price Pharmacy |
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Trigrim 2.5 mg tablets 30 pcs. 222 r Buy |
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Trigrim tab. 2.5mg n30 245 RUB Buy |
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Trigrim 10 mg tablets 30 pcs. RUB 300 Buy |
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Trigrim 5 mg tablets 30 pcs. 336 r Buy |
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Trigrim tab. 5mg n30 368 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
