Tazan - Instructions For The Use Of Tablets, Price, Reviews, Analogues

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Tazan - Instructions For The Use Of Tablets, Price, Reviews, Analogues
Tazan - Instructions For The Use Of Tablets, Price, Reviews, Analogues

Video: Tazan - Instructions For The Use Of Tablets, Price, Reviews, Analogues

Video: Tazan - Instructions For The Use Of Tablets, Price, Reviews, Analogues
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Tazan

Tazan: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. Drug interactions
  13. 13. Analogs
  14. 14. Terms and conditions of storage
  15. 15. Terms of dispensing from pharmacies
  16. 16. Reviews
  17. 17. Price in pharmacies

Latin name: Tazan

ATX code: M01AX

Active ingredient: chondroitin sodium sulfate (Chondroitin sulfate sodium) + glucosamine (Glucosamine)

Producer: Sintez, JSC (Russia)

Description and photo updated: 2020-18-01

Film-coated tablets, Tazan
Film-coated tablets, Tazan

Tazan is a combined preparation that stimulates the regeneration of cartilage tissue.

Release form and composition

The drug is produced in the form of film-coated tablets: biconvex, oval, film shell - from almost white to white; possible surface roughness (5 or 15 pieces in a blister strip or 30, 60 or 90 pieces in a polymer can, in a cardboard box instructions for the use of Tazan and 6, 12 or 18 blisters of 5 pieces, or 2, 4 or 6 packs of 15 pcs., or 1 can).

1 tablet contains:

  • active ingredients: glucosamine sulfate sodium chloride (in terms of glucosamine sulfate) + chondroitin sodium sulfate - 250 mg + 250 mg / 500 mg + 500 mg;
  • additional components: calcium stearate, colloidal silicon dioxide (aerosil), low molecular weight povidone (medical low molecular weight polyvinylpyrrolidone 12 600 + 2700), potato starch, crospovidone (Kollidon CL; additionally for a dose of 250 mg + 250 mg - Kollidon CL-M), tall ludipress (lactose monohydrate - 91–95%, povidone - 3–4%, crospovidone - 3–4%);
  • film shell: propylene glycol, macrogol (polyethylene glycol 4000), hypromellose (hydroxypropyl methylcellulose), titanium dioxide.

Pharmacological properties

Pharmacodynamics

Tazan activates the process of cartilage tissue regeneration. The active substances of the drug are involved in the synthesis of connective tissue, helping to prevent the destruction of cartilage tissue and stimulating its regeneration. The use of exogenous glucosamine increases the production of cartilage matrix (chondrocytes and extracellular substance) and the degree of nonspecific protection against chemical damage to cartilage.

Glucosamine in the sulfate salt form is a precursor to hexosamine, and the sulfate anion plays an important role in the production of glycosaminoglycans. It is also assumed that glucosamine protects damaged cartilage from metabolic destruction caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticosteroids (GCS), and also has its own moderate anti-inflammatory effect.

Chondroitin sulfate, regardless of whether it is absorbed in intact form or as a group of individual components, acts as an additional substrate for the formation of a healthy cartilage matrix. The active ingredient stimulates the production of hyaluronone, proteoglycans and type II collagen, protects the matrix of cartilage tissue from enzymatic degradation (by inhibiting the activity of elastase and hyaluronidase) and from the destructive effects of free radicals, normalizes the viscosity of synovial fluid, stimulates the reparative processes of cartilage. When used for the treatment of osteoarthritis, the agent reduces the symptoms of the disease and reduces the need for NSAIDs.

Pharmacokinetics

Glucosamine

When taken orally, bioavailability is 25% (first pass effect through the liver). After distribution in tissues, the highest concentrations of the active substance are detected in the kidneys, liver and articular cartilage. Approximately 30% of the administered dose persists for a long time in muscle and bone tissues. The half-life (T 1/2) is 68 hours, the drug is excreted mainly by the kidneys unchanged, and some part - by the intestines.

Chondroitin sulfate

After oral administration of the drug at a single dose of 0.8 g (or 2 times a day at 0.4 g), the plasma level of chondroitin sulfate increases within 24 hours. In the form of low molecular weight and high molecular weight derivatives, approximately 20 and 10% of the administered dose are absorbed, respectively. The absolute bioavailability of the active substance is 12%, the apparent volume of distribution (V d) is about 0.44 ml / g. It is metabolized by desulfurization, excreted by the kidneys, T 1/2 - 310 min.

Indications for use

Tazan is recommended for use for the treatment of grade I – III osteoarthritis.

Contraindications

Absolute:

  • severe renal impairment;
  • age up to 15 years (for a dose of 250 mg + 250 mg) or up to 18 years (for a dose of 500 mg + 500 mg);
  • pregnancy and lactation;
  • hypersensitivity to any component of Tazan tablets.

Relative (use with caution):

  • bronchial asthma;
  • diabetes;
  • tendency to bleeding;
  • bleeding.

Tazan, instructions for use: method and dosage

Tazan tablets are taken orally.

It is recommended to use the drug in a single dose of 2 tablets (250 mg + 250 mg) or 1 tablet (500 mg + 500 mg) 2 times a day - during the first three weeks of the course and 1 time a day - for the following weeks and months.

A stable therapeutic effect is observed with a course of treatment for at least 6 months.

Side effects

  • cardiovascular system: tachycardia;
  • digestive system: flatulence, epigastric pain, constipation / diarrhea;
  • nervous system: headache, dizziness, drowsiness / insomnia;
  • allergic reactions: skin manifestations of allergies, extremely rarely - other types of reactions;
  • others: peripheral edema, pain in the legs.

Overdose

No cases of Tazan's overdose have been recorded. If an overdose is suspected, gastric lavage is required and symptomatic treatment is prescribed.

special instructions

In the event of adverse events from the digestive tract, it is recommended to reduce the dose of Tazan by 2 times, and if there is no improvement in the condition, to cancel the drug treatment.

If the clinical effect was not achieved after four weeks of taking Tazan in a daily dose of 8 tablets (250 mg + 250 mg) or 4 tablets (500 mg + 500 mg), it is necessary to decide on additional studies to clarify the diagnosis.

Influence on the ability to drive vehicles and complex mechanisms

During the period of treatment, care should be taken when driving motor vehicles and controlling other complex mechanisms.

Application during pregnancy and lactation

Pregnant and lactating women should not use Tazan.

Pediatric use

It is contraindicated to take Tazan at a dosage of 250 mg + 250 mg for children and adolescents under 15 years of age and at a dosage of 500 mg + 500 mg for children under 18 years of age (due to the lack of information confirming the effectiveness and safety of taking the drug in patients of these age groups).

With impaired renal function

Tazan is contraindicated in persons with severe renal impairment.

Drug interactions

  • tetracyclines: the absorption of these drugs increases;
  • antiplatelet agents, anticoagulants, fibrinolytics: the effect of these agents is enhanced;
  • semi-synthetic penicillins: their effect decreases;
  • NSAIDs, GCS: the compatibility of the drug with these drugs is recorded.

Analogs

Tazan's analogues are Teraflex, Artravir-complex-INCAMFARM, Artra, Kondronova, Artrafik Pro, Struktum, Chondrogluxid, Hondroflex, etc.

Terms and conditions of storage

Store in places protected from light, out of the reach of children, at a temperature not exceeding 25 ˚С.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Tazan

Reviews about Tazan found on specialized sites are rather contradictory. Some patients consider it an effective remedy for the treatment of osteoarthritis, because after a long course of treatment with the drug, the severity of the symptoms of the disease significantly decreased - the swelling and stiffness in the affected joints disappeared, pain and inflammation were stopped.

Another group of patients notes only a slight improvement in their condition or a complete absence of positive changes after a course of taking Tazan. Many indicate the development of side effects during therapy in the form of diarrhea, nausea, dizziness, insomnia and weakness. Sometimes they complain about the lack of the drug in pharmacies.

Price for Tazan in pharmacies

On average, the price of Tazan in the form of film-coated tablets (500 mg + 500 mg) is 1200 rubles. per package containing 90 pcs.

Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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