Dihydrotachysterol
Dihydrotachysterol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological action
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in the elderly
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Dihydrotachysterol
ATX code: A11CC02
Active ingredient: Dihydrotachysterol (Dihydrotachysterol)
Manufacturer: ZAO NPK EHO, Russia
Description and photo update: 2019-06-08
Prices in pharmacies: from 329 rubles.
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Dihydrotachysterol is a drug that regulates the exchange of phosphorus and calcium in the body.
Release form and composition
Dihydrotachysterol is produced in the form of drops for oral administration of 0.1% (in dark glass vials or dropper bottles of 10, 15, 20, 30 or 50 ml).
The composition of 1 ml drops includes:
- Active ingredient: dihydrotachysterol - 1 mg;
- Auxiliary components: sunflower or soy refined deodorized oil - up to 1 ml.
pharmachologic effect
Pharmacodynamics
Dihydrotachysterol is a provitamin D3, similar in structure to vitamin D2. With the suppressed function of the parathyroid glands, the drug increases the absorption of calcium in the intestine and increases the concentration of this trace element in the blood. The drug reduces the activity of alkaline phosphatase, preventing the development of osteoporosis. For dihydrotachysterol, a weak anti-rachitic effect is characteristic.
Increasing the permeability of the intestinal mucosa for calcium and phosphorus ions ensures their accumulation in bone tissue. Dihydrotachysterol also takes part in the process of phosphate reabsorption in the renal tubules.
The drug can be used in long courses of treatment: it is not addictive, and cases of overdose are rare. The result of the action of the active ingredient becomes noticeable rather quickly (from several days to 1-2 weeks). However, the duration of exposure to dihydrotachysterol on the body is shorter than in the case of vitamin D, so the risk of developing hypercalcemia will be minimal. After the end of the course of therapy, the effect of using the drug lasts up to 9 weeks. The toxic effect is manifested when the drug is taken at a dose of 25 mg per day or more and is expressed in the appearance of symptoms of hypercalcemia.
Pharmacokinetics
After oral administration on an empty stomach, up to 90% of dihydrotachysterol is absorbed in the gastrointestinal tract. The compound undergoes biotransformation in the liver, forming the active metabolite 25-hydroxyhydrotachysterol, which circulates in the blood and is resistant to further oxidation. The drug does not cause tolerance and penetrates the placental barrier and into breast milk.
The maximum therapeutic effect is observed 8 hours after the start of admission. Dihydrotachysterol is metabolized in the liver and excreted in urine, bile and feces. The half-life is 10.5-13 hours.
Indications for use
- Tetania (muscle cramps caused by hypocalcemia);
- Pseudohypoparathyroidism;
- Hypoparathyroidism (postoperative and idiopathic);
- Bone diseases due to vitamin D deficiency.
Contraindications
- Hypervitaminosis D;
- Hypercalcemia;
- Hypersensitivity to the components of the drug, as well as to other vitamin D preparations.
Instructions for the use of Dihydrotachysterol: method and dosage
Dihydrotachysterol is taken orally.
The frequency of admission is determined by the indications and the concentration of calcium in the urine and blood. Typically, the daily dose ranges from 0.25 to 1.5 mg.
Side effects
During therapy, the following side effects may develop:
- Urinary system: with prolonged treatment - functional disorders of the kidneys;
- Cardiovascular system: palpitations; rarely - heart rhythm disturbances;
- Digestive system: diarrhea, anorexia, vomiting, nausea; when taken in high doses - biliary dyskinesia;
- Metabolism: tissue calcification, thirst;
- Others: headache, pallor of the skin.
Overdose
Signs of acute overdose of Dihydrotachysterol are cylindruria, leukocyturia, proteinuria, headache, fever, hypercalcemia, arrhythmia. A chronic overdose of the drug can be suspected by such signs as calcium deposits in the intestines, kidneys, heart, blood vessels, pathological demineralization of bones, anorexia.
In case of hypercalcemic crisis, a 0.9% sodium chloride solution is injected intravenously, to which loop diuretics (furosemide or ethacrynic acid) are added. Dialysis is also indicated.
special instructions
According to the instructions, Dihydrotachysterol should be taken with caution in patients with urolithiasis.
Concomitant use of other D vitamins, parathyroid drugs and calcium supplements is not recommended.
Patients with allergic reactions to nuts (including allergies to peanuts) should not take the drug.
With simultaneous use with thyroid hormone replacement therapy, it may be necessary to adjust the dosage regimen of Dihydrotachysterol.
Application during pregnancy and lactation
If dihydrotachysterol must be prescribed to a pregnant woman, the potential benefits of therapy for the mother and the risk of developing abnormalities in the fetus should be carefully weighed.
The active substance of the drug is excreted in breast milk and can become a provoking factor for the development of hypercalcemia in an infant.
Use in the elderly
The drug is used with caution in elderly patients.
Drug interactions
When some drugs are used together, undesirable effects may occur:
- Cardiac glycosides and calcium antagonists: it is possible to increase their action (a decrease in their doses may be required);
- Rifampicin, thiazide diuretics, vitamin D, as well as calcium-containing drugs and food additives: hypercalcemia may develop;
- Vaseline oil, barbiturates (phenobarbital), anion exchange resins (colestipol, colestyramine), antiepileptic drugs (carbamazepine (finlepsin), phenytoin (diphenin), primidone (hexamidine)): the effect of dihydrotachisterol may be weakened.
With simultaneous use with thyroxine, after its cancellation, hypercalcemia may develop.
Analogs
Dihydrotachysterol analogs are: A. T. 10, Alphadol SA, Alpha D3-Teva, Vigantol, Oksidevit, Etalfa.
Terms and conditions of storage
Store in a dark place, out of reach of children, at a temperature of 0-15 ° C.
The shelf life is 2.5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Dihydrotachysterol
According to reviews, Dihydrotachysterol is prescribed to patients with hypoparathyroidism, accompanied by a reduced rate of calcium absorption in the intestine. In this case, monotherapy with calcium preparations does not allow achieving the required concentration in the blood. It is advisable to prescribe vitamin D in the form of Dihydrotachysterol, which promotes the absorption and assimilation of calcium.
The drug increases the permeability of the intestinal mucosa for calcium and increases the rate of excretion of phosphate through the kidneys. However, patients with hypoparathyroidism should take dihydrotachysterol regularly. The drug is very effective and allows you to eliminate symptoms such as cramps, facial numbness, muscle pain. However, it is taken only as directed by a doctor and with constant monitoring of the calcium content in the blood.
Price for Dihydrotachysterol in pharmacies
The price for a bottle of Dihydrotachysterol 0.1% with a volume of 10 ml in pharmacies is approximately 330-380 rubles.
Dihydrotachysterol: prices in online pharmacies
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Drug name Price Pharmacy |
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Dihydrotachysterol 0.1% drops for oral administration (in oil) 10 ml 1 pc. 329 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
