Pancreasim
Pancreasim: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Pancreazim
ATX code: A09AA02
Active ingredient: pancreatin (Pancreatin)
Producer: Technologist, PrJSC (Ukraine)
Description and photo update: 2019-09-07
Pancreasim is an enzyme preparation that improves digestion.
Release form and composition
Dosage form - enteric tablets: pink, round biconvex, with an unexpressed specific odor (in a cardboard box 2 or 5 blisters of 10 tablets and instructions for the use of Pancreasim).
The active substance in 1 tablet is pancreatin, with the following enzymatic activity:
- lipolytic - 8000 Ph. Eur. U. (units of biological activity according to the European Pharmacopoeia);
- amylolytic - 5600 Ph. Eur. U.;
- proteolytic - 370 Ph. Eur. U.
Auxiliary components: propylene glycol, methacrylate copolymer dispersion, anhydrous colloidal silicon dioxide, sodium chloride, microcrystalline cellulose, croscarmellose sodium, crospovidone, povidone 25, magnesium stearate, talc, carmoisin, titanium dioxide.
Pharmacological properties
Pharmacodynamics
Pancreasim is one of the polyenzyme drugs. Lipase, amylase and protease - pancreatic enzymes included in its composition, facilitate the digestion of fats, proteins, carbohydrates and, as a result, their complete absorption in the small intestine.
In patients with diseases of the pancreas, Pancreasim compensates for the insufficiency of its exocrine function, which improves the digestion process.
Pharmacokinetics
The tablet is covered with a protective shell, insoluble in the acidic contents of the stomach. Thanks to this, the enzymes are protected from destruction under the influence of the pH of the gastric juice.
Indications for use
- conditions after simultaneous resection of the small intestine and stomach, intestinal disorders, functional acceleration of the passage of food through the intestines, the simultaneous use of heavily digestible plant, unusual and fatty foods;
- diseases that are accompanied by a violation of the process of digestion of food associated with insufficient secretion of digestive enzymes by the pancreas, including chronic pancreatitis;
- preparation for ultrasound / X-ray diagnostic tests, intestinal distention.
Contraindications
Absolute:
- exacerbation of chronic pancreatitis, acute pancreatitis;
- age up to 18 years;
- individual intolerance to the components of the drug.
Relative (Pancreasim tablets are used under medical supervision):
- pregnancy;
- lactation period.
Pancreasim, instructions for use: method and dosage
Pancreasim is taken orally with meals. The tablets should be swallowed whole with a large amount of liquid, for example 200 ml of water.
The dosage regimen and the duration of the course is set individually and is determined by the deficiency of pancreatic enzymes in the duodenum.
In the absence of other recommendations, as well as when using heavily digestible plant foods, unusual or fatty foods, take 1-2 tablets. The recommended dose of Pancreasim in other cases with the development of digestive disorders is 2–4 tablets. According to indications, the dose can be increased. If the dose is increased in order to reduce the symptoms of the disease, for example, abdominal pain or steatorrhea, a doctor's consultation is necessary.
The maximum daily dose of lipase is 15,000–20,000 Ph. Eur. U. per 1 kg of body weight.
Side effects
- immune system: immediate allergic reactions (in the form of skin rash, sneezing, lacrimation, bronchospasm); the development of allergic reactions may be associated with the presence of the dye carmoisin (E122) in the Pancreasim tablets;
- genitourinary system: in patients with cystic fibrosis - increased excretion of uric acid with urine, especially while taking high doses of pancreatin; to avoid the formation of uric acid calculi in such patients, it is necessary to monitor its content in the urine;
- digestive system: in patients with cystic fibrosis, when taking high doses - the formation of a narrowing in the ileocecal area and the ascending part of the colon abdominal pain, nausea, diarrhea, changes in the nature of bowel movements, vomiting; possibly constipation, bowel obstruction.
Overdose
- main symptoms: nausea, vomiting, diarrhea, hyperuricemia, intestinal obstruction, perianal skin irritation, uricosuria;
- therapy: canceling Pancreasim, ensuring adequate hydration, carrying out symptomatic treatment as needed.
special instructions
The tablets should be swallowed whole, without chewing, since Pancreasim contains active enzymes that can damage the oral mucosa.
Application during pregnancy and lactation
Pancreasim during pregnancy / lactation can only be taken as prescribed by a doctor after assessing the ratio of the expected benefit and possible risk.
Pediatric use
The safety profile of Pancreazim in patients under 18 years of age has not been studied, therefore the drug is not prescribed to children.
Drug interactions
The use of preparations containing pancreatin may be accompanied by a decrease in the absorption of folic acid, which can lead to the need for its additional intake into the body.
Analogs
The analogues of Pancreasim are Gastenorm forte, Creon, Pancreatin, Mezim, Micrasim, PanziKam, Pancitrat, Pancrelipaza, Pancurmen, Pancreoflat, Festal, Ermital, Penzital.
Terms and conditions of storage
Store at temperatures up to 25 ° C in original packaging. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Pancreasim
Reviews about Pancreasim are mostly positive. It is characterized as an inexpensive drug that is not inferior in efficiency to analogues. Side effects are rarely reported.
Price for Pancreasim in pharmacies
The price of Pancreasim is unknown, since the drug is not available in pharmacies.
The approximate cost of analogs:
- Creon 10,000 (20 enteric capsules 10,000 U each) - 305 rubles;
- Mezim 20,000 (20 enteric tablets, 20,000 units each) - 246 rubles;
- Pancreatin (50 enteric tablets, 125 mg each) - 48 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
