Gistan-N
Gistan-N: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Method of application and dosage
- 5. Side effects
- 6. Overdose
- 7. Special instructions
- 8. Application during pregnancy and lactation
- 9. Use in childhood
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Histan-N
ATX code: D07AC13
Active ingredient: mometasone (Mometasone)
Manufacturer: Oxford Laboratories, Pvt. Ltd. (Oxford Laboratories, Pvt. Ltd.) (India)
Description and photo update: 2019-11-07
Prices in pharmacies: from 83 rubles.
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Gistan-N is a local drug with anti-inflammatory, anti-exudative and antipruritic effects.
Release form and composition
Dosage form - cream for external use: white, homogeneous (5 or 15 g in aluminum tubes; in a cardboard box 1 tube and instructions for Gistan-N).
Composition of 1000 mg cream:
- active substance: mometasone furoate - 1 mg;
- auxiliary components: propylene glycol - 60 mg; chlorocresol - 1 mg; emulsion wax - 95 mg; sodium citrate - 1 mg; white soft paraffin - 185.64 mg; liquid paraffin - 35.66 mg; cetomacrogol - 2 mg; water - up to 1000 mg.
Pharmacological properties
Pharmacodynamics
Mometasone - the active substance of Histana-N, is a synthetic GCS (glucocorticosteroid). It has anti-inflammatory, anti-exudative and antipruritic effects.
The pharmacological action of the drug is aimed at inducing the release of proteins that inhibit phospholipase A 2 and lipocortins, which control the synthesis of prostaglandins and leukotrienes (inflammatory mediators), by inhibiting the release of arachidonic acid, their common precursor.
The main effects of mometasone:
- prevention of marginal accumulation of neutrophils, which leads to a decrease in inflammatory exudate and production of cytokines, inhibition of macrophage migration and helps to reduce the processes of infiltration and granulation;
- a decrease in inflammation, which is provided by a decrease in the formation of a chemotaxis substance (has an effect on late allergy reactions);
- inhibition of the development of an immediate allergic reaction (the effect is based on inhibition of the production of metabolites of arachidonic acid and a decrease in the release of inflammatory mediators from mast cells).
With daily use in children with allergic dermatitis over 2 years of age, the therapeutic effect manifests itself in 3 weeks.
Pharmacokinetics
When applied topically, mometasone has a low degree of absorption. Approximately 0.4% of the dose is found in the systemic circulation 8 hours after application of the drug to intact skin (without using an occlusive dressing). In the event of damage and inflammation of the skin, the degree of absorption increases.
Indications for use
Gistan-N is prescribed for the treatment of dermatoses (including psoriasis, atopic and seborrheic dermatitis), accompanied by inflammation and itching of the skin, in which the use of GCS is indicated.
Absolute:
- perioral dermatitis, rosacea;
- tuberculosis, syphilis;
- bacterial, fungal or viral (chickenpox, Herpes simplex, Herpes zoster) infectious skin lesions;
- post-vaccination reactions;
- pregnancy and lactation (when applied to large areas of the skin, long-term therapy);
- age up to 2 years;
- individual intolerance to the components of the drug or other GCS.
Relative (Gistan-N cream is prescribed under medical supervision):
- application to the intertriginous surface of the skin and facial skin;
- the use of occlusive dressings;
- application on large areas of the skin and / or a long course (especially in children).
Gistan-N, instructions for use: method and dosage
Gistan-N cream is applied externally.
The drug is applied once a day in a thin layer to the affected skin areas.
The duration of use varies in the range from 7 to 28 days and depends on the effectiveness of treatment, the tolerability of the drug, the presence and severity of adverse events.
Side effects
With long-term use of Gistan-N and / or application to large areas of the skin (when the total area is larger than the area of the patient's palm), as well as when using occlusive dressings, especially in children and adolescents, it is possible to develop undesirable phenomena characteristic of systemic corticosteroids. including Itsenko-Cushing's syndrome and adrenal insufficiency.
Also during the period of therapy, local reactions may develop: paresthesias, burning, skin atrophy, acne, hypopigmentation, hypertrichosis, pruritus, folliculitis, perioral dermatitis, allergic contact dermatitis, striae, secondary infection, prickly heat, skin maceration.
When using occlusive dressings, the likelihood of the listed adverse reactions increases.
Overdose
- the main symptoms of a mometasone overdose: inhibition of the function of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency;
- therapy: symptomatic. If necessary, the electrolyte balance is corrected and Gistan-N is canceled (after long-term treatment, the drug is canceled gradually).
special instructions
If after the application of Histana-N for two weeks there is no improvement, you should consult a doctor and clarify the diagnosis.
Since during a long course / use of large doses of the drug, the development of the systemic action of GCS is possible, during the period of therapy it is necessary to monitor the function of the hypothalamic-pituitary-adrenal system.
Avoid getting the cream in the eyes.
The propylene glycol contained in the application may cause irritation. In such cases, Gistan-N is canceled and appropriate treatment is prescribed.
GCS can alter the manifestation of some skin diseases, which can complicate the diagnosis. You also need to take into account that Gistan-N can delay wound healing.
Sudden discontinuation of therapy after prolonged use of the drug can lead to the onset of rebound syndrome, manifested as dermatitis with a burning sensation and intense redness of the skin. In this regard, Gistan-N should be canceled gradually.
Application during pregnancy and lactation
The safety profile of mometasone furoate during pregnancy / lactation has not been studied.
The use of Histana-N for a long course and in high doses should be avoided during pregnancy. Furoata mometasone crosses the placental barrier and may have a negative effect on fetal development.
Furoata mometasone is excreted in breast milk. If you intend to use large doses of the drug and / or a long course, breastfeeding should be discontinued.
Pediatric use
For patients under 2 years of age, the drug is not prescribed.
The value of the ratio of surface area and weight in children is greater than in adults, therefore, with the use of any local GCS in pediatric patients, there is a greater risk of developing Itsenko-Cushing syndrome and suppression of the function of the hypothalamic-pituitary-adrenal system. With long-term treatment with Gistan-N, children may experience a violation of their development and growth. Treatment for longer than three weeks has not been studied.
In children, Gistan-N should be used in the minimum dose sufficient to achieve the effect.
Drug interactions
There is no information.
Analogs
Analogs of Gistan-N are Avecort, Momat, Monovo, Mometazon, Momederm, Elokom, Elokom Lotion, Silkaren, etc.
Terms and conditions of storage
Store at temperatures up to 25 ° C, do not freeze. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gistan-N
Most often, in reviews of Gistan-N, patients indicate that the drug has the declared therapeutic effect. With an exacerbation of atopic dermatitis, almost after the second application of the cream, peeling and redness of the skin decreases, itching and the desire to constantly comb the rash are stopped. The exacerbation takes place after a week of regular use of the cream. Gistan-N, according to many, is a good tool at an affordable price.
Price for Gistan-N in pharmacies
The approximate price for Gistan-N, cream for external use, 1 tube of 15 g, is 149 rubles.
Gistan-N: prices in online pharmacies
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Drug name Price Pharmacy |
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Gistan-N 0.1% cream for external use 15 g 1 pc. 83 rbl. Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
