Normase
Normaze: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Normase
ATX code: A06AD11
Active ingredient: lactulose (lactulose)
Producer: L. Molteni & C. dei Fratelli Alitti Societa di Esercizio (Italy), Fresenius Kabi Austria (Austria)
Description and photo updated: 2019-27-08
Prices in pharmacies: from 216 rubles.
Buy
Normase is a laxative that stimulates intestinal motility, improves the absorption of calcium and phosphate salts, and has a hypoammonoemic and hyperosmotic effect.
Release form and composition
Dosage form - syrup: transparent, colorless or light yellow with a brownish tint (200 ml in dark glass bottles, in a cardboard box 1 bottle with a measuring cup and instructions for use for Normaze).
Active ingredient: lactulose, its content in 1 g of syrup is 0.667 g.
Additional components: purified water, citric acid, creamy flavor (vanillin, dihydrocoumarin and propylene glycol).
Pharmacological properties
Pharmacodynamics
Lactulose is a substance with a laxative, hyperosmotic, hypoammonaemic effect, improves the absorption of calcium salts and phosphates, stimulates intestinal motility.
Under the influence of lactulose, there is a change in the flora of the colon (due to an increase in the number of lactobacilli). This leads to an increase in acidity in the lumen of the colon and stimulates peristalsis. At the same time, the volume of feces increases and their softening occurs. Thus, Normase exhibits a laxative effect without directly affecting the smooth muscles and the mucous membrane of the colon.
Ammonia under the action of the drug passes from the blood to the intestine, which helps to reduce the formation of nitrogen-containing toxic substances in its proximal section and, therefore, their absorption into the vena cava system.
The action of Normase can develop quickly or be delayed (after 24–48 hours).
Lactulose has the ability to inhibit the growth of Salmonella in the colon. It is not addictive and does not reduce the absorption of vitamins.
Pharmacokinetics
Lactulose has low absorption.
It is excreted unchanged through the intestines, 3% is excreted by the kidneys.
Indications for use
- Dysbacteriosis;
- Chronic constipation
- Salmonellosis (with the exception of generalized forms of the disease);
- Hyperammonemia;
- Hepatic encephalopathy;
- Hepatic precoma and coma.
Also, Normase is prescribed to regulate stool for hemorrhoids, in the pre- and postoperative period during surgical intervention in the anus and on the colon.
Contraindications
Absolute:
- Rectal bleeding (not hemorrhoidal)
- Bowel obstruction;
- Suspected appendicitis;
- Ileostomy;
- Colostomy;
- Galactosemia;
- Intolerance to fructose or galactose;
- Hypersensitivity to drug components.
Normase should be used with caution in patients with diabetes mellitus.
Normaze, instructions for use: method and dosage
Normase syrup should be taken orally after meals.
Recommended dosing regimens for constipation:
- Adults: the first 3 days - 15-40 ml per day, then - 10-25 ml per day;
- Children over 6 years old: the first 3 days - 15 ml per day, then - 10 ml per day;
- Children 1-6 years old - 5-10 ml per day;
- Children under 1 year old - 5 ml per day.
Constipation treatment can last from 4 weeks to 4 months.
Recommended dosage regimens if stool regulation is necessary in the postoperative period:
- Adults: 10-30 ml 3 times a day;
- Children over 1 year old - 5-10 ml 2-3 times a day;
- Children under 1 year old: 5 ml 2-3 times a day.
It is recommended to start taking the drug 18-24 hours after surgery. The course of therapy is 3-5 days.
With hyperammonemia, encephalopathy, hepatic precoma and coma, at the beginning of treatment, 30-60 ml of syrup is prescribed 3 times a day. In the future, the dose is selected individually, so that soft stools are 2-3 times a day. The duration of treatment is also determined for each patient individually. You can take the drug for 3 or more months.
Side effects
In some cases, diarrhea, flatulence and nausea occur during the treatment with Normase.
In patients with hepatic encephalopathy, taking the drug in large doses for a long period, due to diarrhea, water-electrolyte metabolism may be disturbed.
Overdose
There is no information.
special instructions
With gastrocardiac syndrome, in order to avoid flatulence, it is recommended to gradually increase the dose.
With long-term treatment (more than 6 months), it is necessary to regularly monitor the content of carbon dioxide, chlorine and potassium in the blood plasma.
Application during pregnancy and lactation
The drug is approved for use during pregnancy and during breastfeeding.
Pediatric use
In pediatrics, the drug is used according to indications and according to the dosage regimen, taking into account the patient's age.
Drug interactions
Lactulose alters the pH-dependent release rate of enteric drugs, so Normase should not be taken within 2 hours of taking any other drug.
Antacids and antibiotics used simultaneously reduce the effectiveness of lactulose.
Analogs
Normase's analogues are: Goodluck, Duphalac, Romfalak, Lactusan, Lactuvit, Lactulose, Lactulose Stada, Normolact, Portalak.
Terms and conditions of storage
Keep out of the reach of children. Observe the temperature regime from 15 to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Normaz
Reviews about Normaz are mostly positive. Indicate that the effect of the drug develops rapidly. The advantages include ease of use, pleasant taste, no restriction of intake in pregnant and lactating women and in children. The development of adverse reactions, as well as insufficient therapeutic effect, are rarely reported.
Price for Normaz in pharmacies
The approximate price for Normaz (1 bottle of 200 ml) is 255–286 rubles.
Normaze: prices in online pharmacies
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Drug name Price Pharmacy |
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Normase syrup 200 ml 1 pc. 216 r Buy |
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Normase syrup 667mg / ml 200ml 223 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
