Infezol 100
Infezol 100: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Infesol 100
ATX code: B05BA01; B05BA10
Active ingredient: amino acids for parenteral nutrition + other drugs (minerals) [Aminoacids for parenteral nutrition + Other medicines (Multiminerals)]
Producer: Berlin-Chemie, AG (Berlin-Chemie, AG) (Germany)
Description and photo update: 2019-11-07
Infezol 100 is a drug for parenteral nutrition that compensates for the deficiency of electrolytes, amino acids and carbohydrates.
Release form and composition
The drug is produced in the form of a solution for infusion, which is a transparent liquid, almost colorless or with a slight yellowish tinge, with a specific odor (250 ml or 500 ml each in glass vials, sealed with rubber stoppers for piercing and closed with plastic lids under aluminum rolling; in a cardboard box of 10 bottles and instructions for use of Infezol 100).
The composition of the active ingredients (per 1 liter of solution for infusion):
- L-alanine - 15.5 g;
- lysine monoacetate - 10.02 g (corresponds to 7.1 g of L-lysine);
- L-arginine - 9.66 g;
- glycine - 7.55 g;
- L-proline - 7.5 g;
- L-leucine - 6.24 g;
- L-isoleucine 5.85 g
- L-phenylalanine 5.4 g;
- L-valine - 5 g;
- L-threonine - 5 g;
- L-glutamic acid - 5 g;
- L-methionine - 4.68 g;
- L-serine - 4.3 g;
- L-histidine 3.3 g;
- malic acid - 3 g;
- ornithine hydrochloride - 2.42 g (corresponds to 1.9 g of L-ornithine);
- L-tryptophan - 2 g;
- acetyltyrosine - 2 g (corresponds to 1.62 g of L-tyrosine);
- L-aspartic acid 1.91 g;
- acetylcysteine - 0.673 g (corresponds to 0.5 g of L-cysteine);
- sodium acetate trihydrate - 3.456 g;
- potassium chloride - 3.355 g;
- sodium hydroxide - 1.324 g;
- magnesium chloride hexahydrate - 1.017 g;
- calcium chloride dihydrate - 0.735 g;
- sodium chloride - 0.625 g.
Water for injection in the amount of 921.735 g (per 1 liter) acts as an auxiliary component.
The total nitrogen content per 1 liter of solution is 15.6 g; the total amino acid content is 100 g. The pH value of the preparation is from 5.9 to 6.3, the energy value is 400 kcal (1700 kJ), and the theoretical osmolarity is 1145 mOsmol / l.
Pharmacological properties
Pharmacodynamics
All amino acids are essential components for protein synthesis. Infusion solutions, which include amino acids, including Infezol 100, are administered as parenteral nutrition simultaneously with carbohydrates, fats, fluids and electrolytes. The plasma concentration of free amino acids is highly variable. This applies to both individual organic compounds and their total concentration.
The drug is intended for intravenous administration, so its bioavailability is 100%.
Pharmacokinetics
The introduced amino acids are used as a substrate for protein synthesis. If some of the amino acids are not consumed for the synthesis of proteins, then they are simply excreted from the body unchanged (about 5%) or undergo further breakdown (in contrast to glucose and fatty acids, which can be reserved in certain stores).
Amino acids are broken down by deamination of the α-amino group, which is metabolized to urea and then excreted through the kidneys. The carbon skeleton of amino acids enters the Krebs cycle, where it is converted first into acetyl-CoA, then into acetoacetyl-CoA, and finally into pyruvate.
Indications for use
- parenteral nutrition (if enteral nutrition is impossible);
- deficiency of proteins of various origins: during operations, burns, blood loss, etc. (treatment and prevention);
- replenishment of fluid loss.
Contraindications
Absolute:
- acute left ventricular failure;
- hemodynamic disorders in the acute stage (including shock);
- total tissue hypoxia;
- severe liver failure;
- traumatic brain injury;
- poisoning with methanol;
- children under 2 years of age.
Relative (Infezol 100 is used with caution, after assessing the expected benefit and possible risk):
- chronic heart failure (I – IIA degree);
- kidney disease;
- metabolic disorders of amino acids;
- a shift in the acid-base balance of the body towards an increase in acidity (acidosis);
- hyponatremia, hyperkalemia;
- excess water in the body.
For patients with renal and / or hepatic insufficiency, the dose of Infezol 100 should be selected individually, monitoring blood biochemical parameters.
Infezol 100, instructions for use: method and dosage
Solution Infezol 100 is intended for intravenous drip (slow). During the procedure, the patient must be closely monitored.
The dosage is determined specifically for each patient, taking into account his condition, as well as the need for fluids, amino acids and electrolytes. At the beginning of the infusion, the infusion rate should be slower within the first hour, it is brought to the desired value.
For adults, the drug is prescribed in a daily dose of 10–20 ml / kg of body weight, which corresponds to 1–2 g of amino acids per kg of body weight. The maximum dose is 20 ml / kg (2 g / kg) per day. For adult patients, the amount of fluid administered (within the framework of appropriate treatment) should not exceed 40 ml / kg of body weight per day.
When prescribing Infezol to 100 children, it is necessary to take into account the child's age, the level of his physical development and the severity of the disease. The average doses of solution for infusion are as follows:
- children aged 2–6 years - 10 ml / kg of body weight (or 1 g of amino acids per kg of body weight) per day;
- children and adolescents aged 6-14 years - 15 ml / kg of body weight (or 1.5 g of amino acids per kg of body weight) per day;
- adolescents 14-18 years old - doses used in adults.
Infezol 100 solution is administered at a rate of not more than 1 ml / kg of body weight per hour (or 0.1 g of amino acids per kg of body weight per hour).
The maximum daily doses of the drug are calculated based on the patient's protein requirement.
The solution for infusion is used until the patient completely switches to the enteral route of nutrition.
Side effects
Side effects usually do not occur, since Infezol 100 is well tolerated. Sometimes allergic reactions (in the form of urticaria and other anaphylactic responses) may occur. Very rarely, as a rule, at an excessively high rate of administration of the solution, the patient develops nausea, vomiting, hyperhidrosis, tachycardia and chills.
Overdose
Overdose of Infezol 100 can lead to overhydration, electrolyte imbalance and amino acid intoxication.
With the rapid introduction or infusion of large doses of potassium-sparing solutions, hyperkalemia may occur. In these cases, the maximum serum potassium concentration exceeds 6.5 mmol / L. Signs of hyperkalemia include sensory disturbances, muscle weakness, and cardiac conduction and cardiac arrhythmias.
In case of drug overdose, it is necessary to reduce the infusion rate or interrupt the administration of the solution. It is recommended to take measures to restore the electrolyte balance. In case of a threat to life, dialysis is prescribed.
special instructions
During the administration of Infezol 100, it is necessary to control the acid-base balance (acid-base composition) of the blood, the serum ionogram, the blood glucose level and the water balance.
The drug is used with caution in patients with increased serum osmolarity.
For full-fledged parenteral nutrition, simultaneously with Infezol 100, it is necessary to introduce other substances - trace elements, vitamins, carbohydrates, fats and electrolytes.
Influence on the ability to drive vehicles and complex mechanisms
There are no data on the effect of Infezol 100 on human psychomotor functions.
Application during pregnancy and lactation
During pregnancy and breastfeeding, the infusion solution is used according to indications.
Pediatric use
Infezol 100 should not be administered to children under 2 years of age.
With impaired renal function
In case of kidney diseases and renal failure, the drug is prescribed with caution, choosing the dose individually for each patient.
For violations of liver function
Infezol 100 is contraindicated in persons with severe hepatic impairment. In the case of mild to moderate liver failure, the drug is prescribed with caution, individually selecting the dose.
Drug interactions
Solutions containing amino acids must not be mixed with other infusion solutions and preparations (to avoid incompatibility and microbial contamination).
Analogs
Infezol 100 analogues are Infezol 40, Aminoven Infant, Aminoplasmal E, Aminoplasmal Hepa, Lipofundin MCT / LST 20%, Lipofundin, Nutriflex 70/240, Nutriflex 40/80 lipid, Nutriflex 48/150 lipid, Nutriflex 70/180 lipid, etc.
Terms and conditions of storage
Store in a dark place, out of the reach of children, at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
The solution must be used immediately after opening the bottle. Only clear solutions from intact vials are suitable for administration.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Infezol 100
The drug is used mainly in stationary conditions, and most often when carrying out intensive therapy and resuscitation measures, so ordinary users, as a rule, do not leave reviews about Infezole 100.
Given the important role of amino acids, it can be said that the drug is not only effective, but also a vital remedy for patients who, for one reason or another, cannot receive adequate nutrition through the gastrointestinal tract.
Price for Infezol 100 in pharmacies
The infusion solution is not available at this time. The last price for Infezol 100 in 250 ml vials (10 pieces in a cardboard box) was about 3300 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
