Proflosin
Proflosin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. With impaired renal function
- 10. For violations of liver function
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Proflosin
ATX code: G04CA02
Active ingredient: tamsulosin (tamsulosin)
Producer: Rottendorf Pharma (Germany)
Description and photo update: 2018-26-10
Prices in pharmacies: from 320 rubles.
Buy
Proflosin is an alpha1-blocker.
Release form and composition
Proflosin is available in the form of enteric capsules of prolonged action: size No. 2, gelatinous, opaque, the capsule body is light orange, the cap is gray-green, the cap has a black line and the inscription "TSL 0.4", on the body there is only a black line; inside capsules - pellets from almost white to white (10 pcs. in a blister, in a cardboard box of 1, 3 or 10 blisters).
1 capsule contains:
- active substance: tamsulosin hydrochloride - 0.4 mg;
- auxiliary components: copolymer of ethyl acrylate and methacrylic acid (1: 1), microcrystalline cellulose, talc, triethyl citrate;
- the composition of the pellet shell: copolymer of ethyl acrylate and methacrylic acid (1: 1), talc, triethyl citrate;
- composition of the capsule cap: gelatin, titanium dioxide, indigo carmine, iron dye yellow oxide, iron dye black oxide;
- composition of the capsule body: gelatin, titanium dioxide, iron dye red oxide, iron dye yellow oxide.
Pharmacological properties
Pharmacodynamics
Proflosin - alpha1-blocker, is used for urination disorders caused by benign prostatic hyperplasia.
The mechanism of action of tamsulosin is due to the competitive and selective blocking of postsynaptic alpha 1A adrenergic receptors of the smooth muscles of the prostate gland, the bladder neck, the prostatic urethra, which leads to a decrease in their tone, and an improvement in urine outflow.
The effect of alpha-adrenergic receptor blockers contributes to a decrease in peripheral vascular resistance and can cause a slight decrease in blood pressure (BP). This effect of tamsulosin does not affect the clinical parameters of patients with normal baseline blood pressure.
Pharmacokinetics
After oral administration, the absorption of tamsulosin from the gastrointestinal tract occurs almost completely and quickly. The rate of its absorption decreases with the simultaneous intake of food.
The maximum concentration in blood plasma after taking a single dose of the drug is reached after about 6 hours.
About 99% of the dose taken is bound to plasma proteins.
The volume of distribution of tamsulosin is 0.2 l / kg.
The metabolism of the active substance occurs slowly in the liver, with the formation of metabolites that are less active than tamsulosin. In the blood, most of tamsulosin is present unchanged. Its ability to induce the activity of liver microsomal enzymes to an insignificant extent has been experimentally confirmed.
It is excreted mainly through the kidneys, including 9% of the drug - unchanged. The half-life with a single dose of 0.4 mg of tamsulosin after meals is approximately 10 hours, with a daily intake - 13 hours.
Indications for use
According to the instructions, Proflosin is indicated only for men for the treatment of dysuric disorders associated with benign prostatic hyperplasia.
Contraindications
- severe liver failure;
- orthostatic hypotension (including history);
- individual intolerance to the components of the drug.
It is recommended to prescribe Proflosin with caution for arterial hypotension, chronic renal failure with creatinine clearance (CC) less than 10 ml / min.
Instructions for the use of Proflosin: method and dosage
Proflosin capsules are taken orally, swallowing whole (the integrity of the capsule shell must not be violated, this will increase the rate of release of the active substance), drinking plenty of water after the first meal.
Recommended dosage: 1 pc. 1 time per day. The duration of the course is not limited.
Side effects
- on the part of the cardiovascular system: infrequently - orthostatic hypotension, tachycardia;
- from the nervous system: often - dizziness; infrequently - headache; rarely - fainting;
- dermatological reactions: infrequently - urticaria, pruritus, rash; rarely - angioedema;
- from the reproductive system: infrequently - violation of ejaculation; very rarely - priapism;
- from the gastrointestinal tract: infrequently - nausea, vomiting, constipation, diarrhea;
- others: in some cases - asthenia, rhinitis, during cataract surgery - the development of a narrow pupil syndrome (atonic iris syndrome).
Overdose
Symptoms: possibly a sharp drop in blood pressure, tachycardia.
Treatment: the patient needs to take a horizontal position, this will ensure recovery to normal blood pressure and heart rate. In order to prevent further absorption of tamsulosin from the gastrointestinal tract, it is advisable to rinse the stomach, take activated charcoal or sodium sulfate (osmotic laxative).
Hemodialysis is not advisable.
special instructions
The appointment of Proflosin should be made on the basis of information obtained as a result of examination of the patient, confirming benign prostatic hyperplasia and the absence of other diseases or conditions with symptoms similar to this disease.
Before starting use and regularly during treatment with the drug, it is necessary to conduct a rectal digital examination, and, if necessary, determine the concentration of a specific prostatic antigen.
If dizziness or weakness appears, which may be the first signs of orthostatic hypotension, the patient is advised to sit down or lie down.
The development of angioedema in a patient while taking the drug indicates hypersensitivity to tamsulosin. Therefore, treatment should be canceled immediately, re-appointment of Proflosin in this case is contraindicated.
With surgery for cataracts, there is a risk of developing atonic iris syndrome in patients taking tamsulosin. Therefore, it is necessary to warn the surgeon about taking the drug so that he can take this into account when preparing and directly carrying out the operation.
Influence on the ability to drive vehicles and complex mechanisms
Due to the risk of dizziness, patients need to be careful when working with complex machinery and driving.
With impaired renal function
Care should be taken to use Proflosin capsules for chronic kidney disease (CC less than 10 ml / min).
For violations of liver function
The appointment of Proflosin is contraindicated in severe hepatic failure.
Drug interactions
With the simultaneous use of Proflosin:
- nifedipine, atenolol, enalapril, theophylline do not cause changes in their pharmacodynamic and pharmacokinetic parameters and tamsulosin parameters;
- other blockers of alpha1-adrenergic receptors can cause a decrease in blood pressure;
- furosemide causes a slight decrease in the concentration of tamsulosin in the blood plasma (dose adjustment is not required);
- cimetidine contributes to a slight increase in the level of concentration of tamsulosin in blood plasma (dose adjustment is not required);
- diclofenac, warfarin increase the rate of drug elimination.
Analogs
The analogues of Proflosin are: Sonisin, Tulozin, Hyperprost, Fokusin, Omnik, Omnik Okas, Tamsulon-FS, Omsulozin, Taniz-K, Revokarin, Tamsulozin-Teva, Tamsulozin retard.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Proflosin
Reviews about Proflosin are mostly positive, they indicate its high clinical effectiveness. The use of the drug for prostatitis allows you to get rid of frequent and painful urination within a short time. Patients "with experience", comparing the drug with expensive analogues, report that it does not have any special differences in action, and if it is necessary to take it daily, this is important.
Some men, confirming the therapeutic effect of the drug, are forced to abandon its use, since they have severe side effects against the background of therapy, including disorientation, light-headedness, and a decrease in blood pressure.
Price for Proflosin in pharmacies
The price of Proflosin for a package containing 30 capsules can range from 440 rubles, 100 capsules - from 1158 rubles.
Proflosin: prices in online pharmacies
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Drug name Price Pharmacy |
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Proflosin 0.4 mg enteric capsules of prolonged action 30 pcs. 320 RUB Buy |
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Proflosin capsules enteric solution. prolonged action 400mkg 30 pcs. 354 r Buy |
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Proflosin 0.4 mg enteric capsules of prolonged action 100 pcs. 932 RUB Buy |
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Proflosin capsules enteric solution. prolonged action 400mkg 100 pcs. 1079 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
