Procto-Glivenol
Procto-Glivenol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. For violations of liver function
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Procto-Glyvenol
ATX code: C05AX03
Active ingredient: tribenoside + lidocaine (tribenoside + lidocaine)
Producer: Novartis Pharma SaS (France), Recordati Industria Chimica & Farmaceutica (Italy), Delpharm Huningue SAS (France)
Description and photo update: 2018-25-10
Prices in pharmacies: from 337 rubles.
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Procto-Glivenol is a local drug with venotonic, local anesthetic and anti-inflammatory effects, used in the treatment of hemorrhoids.
Release form and composition
Dosage forms of release:
- rectal cream: white, homogeneous, has a weak characteristic odor (30 g each in aluminum tubes, in a cardboard box 1 tube complete with a polyethylene tip and a latex cap-cap);
- rectal suppositories: torpedo-shaped, solid, without cracks, somewhat greasy to the touch, yellowish-white, have an unexpressed specific odor (5 pcs. in strips, 2 strips in a cardboard box).
Composition for 100 mg of Procto-Glivenol cream:
- active substances: tribenoside - 5 mg; lidocaine hydrochloride - 2.12 mg;
- auxiliary components: stearic acid - 9 mg; sorbitol - 6 mg; propyl parahydroxybenzoate - 0.05 mg; cetyl alcohol - 5 mg; cetomacrogol 1000 - 4.44 mg; isopropyl palmitate - 2 mg; liquid paraffin - 10 mg; methyl parahydroxybenzoate - 0.18 mg; sorbitan stearate - 1.56 mg; water - 54.65 mg.
Composition for 1 suppository Procto-Glivenol:
- active substances: tribenoside - 400 mg; lidocaine - 40 mg;
- auxiliary components: witepsol E85 - 305 mg; witepsol W35 - 1255 mg.
Pharmacological properties
Pharmacodynamics
Procto-Glivenol is one of the combined antihemorrhoidal drugs.
The main properties of active ingredients:
- tribenoside: improves vascular tone, reduces capillary permeability, antagonistically affects some endogenous substances that play the role of mediators in the development of pain and inflammation;
- lidocaine: has a local anesthetic effect.
The use of Procto-Glivenol leads to a rapid relief of the symptoms of hemorrhoids (pain, itching and skin tension).
Pharmacokinetics
When applying the cream, 2–20% of tribenoside is absorbed. The systemic bioavailability of a substance coming from suppositories reaches 30% of the total amount that is absorbed after ingestion. Cmax (maximum concentration) of tribenoside in blood plasma after rectal administration of 1 suppository is achieved after 2 hours and is 0.001 mg / ml (tribenoside + metabolites).
Tribenoside metabolism occurs mainly in the liver. From 20 to 27% of the dose is eliminated in the form of metabolites in the urine.
Indications for use
According to the instructions, Procto-Glivenol is prescribed for the treatment of external and internal hemorrhoids.
Contraindications
Absolute:
- liver failure;
- I trimester of pregnancy;
- individual intolerance to any component of the drug.
Relative (Procto-Glivenol is prescribed under medical supervision after assessing the benefit / risk ratio):
- II – III trimester of pregnancy;
- lactation period.
Instructions for the use of Procto-Glivenol: method and dosage
The drug is administered rectally.
Recommended frequency of application:
- severe clinical symptoms: 2 times a day (morning and evening);
- regression of acute symptoms: 1 time per day.
Procto-Glivenol cream is injected using a nozzle (1 tube is usually enough for 20-30 doses). Single dose of suppositories - 1 pc.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):
- immune system: very rarely - anaphylactic reactions, including facial edema, angioedema, cardiovascular disorders and bronchospasm;
- skin and subcutaneous tissues: rarely - skin reactions at the site of application in the form of burning, rash, urticaria and itching (symptoms may spread beyond the area of application).
Overdose
There is no information on overdose cases.
Therapy: in case of accidental ingestion of the drug inside, it is recommended to wash the gastrointestinal tract, as well as symptomatic supportive treatment.
special instructions
If during the use of the drug the symptoms of the disease do not diminish, or the development of unusual new sensations is noted, it is necessary to consult a doctor.
During the period of therapy, excessive stress should be avoided, the hygiene of the anal area should be monitored, and measures should be taken to maintain a soft stool consistency.
Application during pregnancy and lactation
- I trimester of pregnancy: Procto-Glivenol is contraindicated;
- II – III trimester of pregnancy and lactation: therapy can be carried out after assessing the benefit / risk ratio.
For violations of liver function
Liver failure: Procto-Glivenol is contraindicated.
Drug interactions
Cases of interaction of Procto-Glivenol with other drugs / substances have not been registered.
Analogs
The analogues of Procto-Glivenol are Pilex, Proctosedil, Relief, Proctan, Belladonna extract, Proctosan, Anusol, Relief Pro, Hemorrone, Bezornil, Betiol, Proctosan Neo, Aurobin.
Terms and conditions of storage
Keep out of reach of children at temperatures up to 30 ° C. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Procto-Glivenol
According to reviews, Procto-Glivenol is an effective drug that quickly relieves the symptoms of hemorrhoids - redness, pain and itching. Of the advantages of suppositories, they indicate a solid structure (they do not melt in the hands), a cream - that it is economical to use, and also that it does not leave greasy stains on linen. Among the disadvantages, the high cost and the likelihood of developing adverse reactions are noted.
Price for Procto-Glivenol in pharmacies
The approximate price for Procto-Glivenol is:
- suppositories (10 per pack): 371–454 rubles;
- cream (1 tube of 30 g each): 368–449 rubles.
Procto-Glivenol: prices in online pharmacies
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Drug name Price Pharmacy |
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Procto-Glivenol rectal cream 30 g 1 pc. 337 r Buy |
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Procto-Glivenol rectal suppositories 10 pcs. 394 r Buy |
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Procto-Glivenol rectal suppositories. 10 pieces. 405 RUB Buy |
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Procto-Glivenol cream rect. 30g 434 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
