Polyphepan
Latin name: Polyphepan
ATX code: A07BC
Active ingredient: lignin hydrolysis (ligninum hydrolisatum)
Manufacturer: Signtek, CJSC (Russia)
Description and photo update: 2019-21-08
Polyphepan is a natural enterosorbent with a non-specific detoxifying effect.
Release form and composition
- Powder for oral administration: amorphous, dark brown, odorless (10, 50, 80, 100, 200 or 250 g each in polymer-coated paper bags or polymer bags, or bags made of combined material, in a cardboard box 10 bags each 10 g or 1 bag of 50, 80, 100, 200 or 250 g);
- Granules for oral administration: irregularly shaped, dark brown, odorless (50 g each in polymer-coated paper bags or polymer bags, or bags of combined material, 100 g each in polymer cans, in a cardboard box 1 bag or 1 can);
- Tablets: flat-cylindrical, dark brown, with a line and beveled (100 pcs. In polymer cans or 10 pcs. In blisters, in a cardboard box 1 can or 3, 5, 10 packs).
The active substance of the preparation: polyphepan (hydrolytic lignin) is a product of hydrolysis of wood components of a polymer of lignin, the structural elements of which are derivatives of hydrocellulose and phenylpropane:
- Powder - 90%;
- 1 g of granules - 0.5 g;
- 1 tablet - 0.375 g.
The auxiliary substance of granules is sucrose, of tablets - lactose (milk sugar).
Pharmacological properties
Pharmacodynamics
Hydrolytic lignin has a high sorption activity and has a non-specific detoxifying effect.
Polyphepan in the lumen of the gastrointestinal tract binds pathogenic bacteria and bacterial toxins, allergens, drugs, heavy metal salts, poisons, alcohol, and then removes them from the body. Also, the drug sorbs excess of certain metabolic products, including bilirubin, cholesterol, urea, metabolites, which are responsible for the development of endogenous toxicosis.
Pharmacokinetics
Polyphepan is not absorbed and is not toxic.
Within 24 hours it is excreted from the intestines in full.
Indications for use
- Exogenous and endogenous toxicosis of various origins (as a detoxifying agent);
- Acute poisoning with drugs, heavy metal salts, alkaloids, alcohol or other poisons (as first aid);
- Complex treatment of food toxicoinfections, dyspepsia, dysbacteriosis, salmonellosis, dysentery and pyoinflammatory diseases, accompanied by intoxication;
- Lipid metabolism disorders (obesity, atherosclerosis);
- Renal and hepatic impairment;
- Food and drug allergies.
According to the instructions, Polyphepan is also used to remove xenobiotics from the body.
Contraindications
- Intestinal atony;
- Anacid gastritis;
- Exacerbation of gastric ulcer and 12 duodenal ulcer;
- Diabetes mellitus (for granules);
- Lactose intolerance (for tablets);
- Hypersensitivity to drug components.
Instructions for the use of Polyphepan: method and dosage
Polyphepan should be taken orally 1 hour before meals or other medications.
The powder and granules must be stirred in a small amount of water (50-100 ml) immediately before taking, and can be taken dry with water.
The tablets can be swallowed whole or crushed and washed down with water.
The dose depends on the type and severity of the disease, ranging from 0.5 to 1 g / kg / day.
Average doses:
- Adults - 1 tbsp. granules / powder 3-4 times a day or 4-6 tablets 3 times a day (6-9 g per day);
- Children over 7 years old - 1 tbsp. granules / powder 3-4 times a day;
- Children 1-7 years old - 1 dess. l. granules / powder 3-4 times a day;
- Infants - ½-1 tsp. powder 3-4 times a day.
The duration of the use of Polyphepan in acute conditions is 3-5 days, with chronic intoxications and allergic diseases - up to 14 days.
If necessary, a second course is carried out after 2 weeks.
Side effects
In the vast majority of cases, Polyphepan is well tolerated; in rare cases, constipation and allergic reactions are possible.
With long-term treatment (more than 20 days), a violation of the absorption of calcium and vitamins is possible.
Overdose
There is no information.
special instructions
With prolonged therapy (more than 20 days), it is additionally recommended to take calcium supplements and multivitamins.
Drug interactions
Polyphepan may reduce the effectiveness of some concomitant oral medications.
Analogs
Polyphepan analogs are: Lactofiltrum, Enterosgel, Ultrasorb, Carbactin, Povidone, Activated carbon, Filtrum STI, Enterodes, Polifan, Polysorb, Smecta.
Terms and conditions of storage
Store in a cool, dry place, out of reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Polyphepan
Reviews of Polyphepan testify to its high efficiency. Indicate that the drug has a small list of contraindications. Also, the advantages include its low cost and availability in pharmacies. The most significant drawback is considered to be unpleasant taste.
Price for Polyphepan in pharmacies
The approximate price for Polyphepan (10 sachets of powder for preparing a suspension for oral administration, 10 g each) is 95 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
