Artradol
Artradol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Artradol
ATX code: M01AX25
Active ingredient: chondroitin sulfate (chondroitin sulfate)
Producer: Kursk biofactory - firm "BIOK", FKP (Russia), Armavir biofabrika, FKP (Russia), FGU "State Institute of Blood Substitutes and Medicines" (FGU GIKiMP) (Russia)
Description and photo updated: 2018-26-11
Prices in pharmacies: from 664 rubles.
Buy
Artradol is a drug for local and systemic use that stimulates the regeneration of cartilage tissue, has a chondroprotective, anti-inflammatory, analgesic effect.
Release form and composition
- lyophilisate for the preparation of a solution for intramuscular (i / m) administration: a porous mass of white with a yellow tint or white compacted into a tablet (ampoules with a capacity of 2 ml: 5 pcs. in a plastic pallet, in a cardboard box 2 pallets; 10 pcs. in cardboard holder, in a cardboard box 1 holder);
- ointment for external use 5%: a light yellow mass with a specific odor (30 g each in glass cans, in a cardboard box 1 can).
The active ingredient of the lyophilisate is chondroitin sodium sulfate (chondroitin sulfate), its content in 1 ampoule is 100 mg (in terms of 100% dry matter).
Composition for 1 g of ointment:
- active substance: sodium chondroitin sulfate (in terms of dry matter) - 0.05 g;
- auxiliary components: dimethyl sulfoxide, anhydrous lanolin, medical petroleum jelly, purified water.
Pharmacological properties
Pharmacodynamics
Artradol is a drug with chondroprotective, anti-inflammatory and analgesic effects, which helps to restore the cartilaginous surfaces of the joints, preventing the collapse of the connective tissue. Participates in the normalization of the synthesis of joint fluid, causing an improvement in joint mobility and a decrease in the intensity of pain. Structural similarity with heparin provides it with the potential to prevent the formation of fibrin thrombi in the synovial and subchondral microvasculature. The effect of the drug is due to the properties of the active substance - chondroitin sulfate, which is the main component of proteoglycans, which together with collagen fibers make up the cartilage matrix.
The chondroprotective properties of chondroitin sulfate make it possible to suppress the activity of enzymes that cause degradation of the articular cartilage, stimulate the production of proteoglycans by chondrocytes, enhance metabolic processes in cartilage and subchondral bone, and stimulate the regeneration of cartilage tissue and phosphorus-calcium metabolism in it. Proteoglycan chondroitin is involved in the construction of the basic substance of cartilage and bone tissue.
The anti-inflammatory and analgesic effect of chondroitin sulfate helps to reduce pain factors through synoviocytes and macrophages of the synovial membrane, the release of inflammatory mediators into the synovial fluid. It inhibits the secretion of leukotriene B4 and prostaglandin E2.
Pharmacokinetics
After the / m of chondroitin sulfate is readily absorbed, after 1 / 4 chasa detected in synovial fluid. In the blood through the 1 / 2 hour, he reaches a significant level of content, and by 1 hour - the maximum concentration (Cmax). Then there is a slow decrease in the concentration of the drug in the blood within 48 hours. Chondroitin tends to accumulate mainly in cartilaginous tissue; 48 hours after administration, its content in the articular cartilage reaches its maximum level.
It is excreted through the kidneys within 24 hours.
When applied externally, Artradol practically does not have systemic absorption.
Indications for use
According to the instructions, Artradol is indicated for the treatment of the following degenerative-dystrophic diseases of the spine and joints:
- intervertebral osteochondrosis;
- primary arthrosis;
- osteoarthritis with predominant involvement of large joints.
Contraindications
The absolute contraindications for the use of lyophilisate are:
- childhood;
- hypersensitivity to the drug.
Care should be taken when prescribing Artradol to patients with thrombophlebitis, bleeding or a tendency to bleed, during pregnancy and lactation.
Artradol ointment is not used in places with a violation of the integrity of the skin and with increased sensitivity to its components.
With care, the ointment is prescribed during pregnancy, during breastfeeding and in childhood.
Instructions for the use of Artradol: method and dosage
A solution prepared from a lyophilisate is intended for intramuscular administration. The contents of the ampoule should be dissolved in 1 ml of water for injection.
Recommended dosage: 100 mg 1 time in 2 days. With good tolerance after three injections, a single dose can be increased to 200 mg. The duration of the course is 25–35 injections.
Repeated therapy is prescribed after 180 days; the doctor sets its duration individually.
The ointment is applied 2-3 times a day in a thin layer on the surface of the skin over the lesion and rubbed in for 2-3 minutes. The duration of the course is from 2 to 3 weeks. It can be repeated if necessary.
Side effects
Allergic reactions may develop against the background of i / m administration of chondroitin sulfate, and hemorrhages at the injection site.
With topical application of chondroitin, in rare cases, hypersensitivity reactions in the form of skin rashes are possible. In this case, Artradol must be canceled.
Overdose
Overdose symptoms have not been established.
special instructions
If it is necessary to conduct concomitant therapy with fibrinolytics, antiplatelet agents or indirect anticoagulants, the patient should be provided with more frequent studies to determine blood coagulation indicators.
Application during pregnancy and lactation
It is recommended to use Artradol with caution during gestation and during breastfeeding.
Pediatric use
There is no information on the efficacy and safety of the drug in children, therefore, the appointment of chondroitin sulfate for intramuscular administration in children is contraindicated.
Artradol ointment in pediatrics is used with caution.
Drug interactions
The simultaneous systemic use of Artradol with antiplatelet agents, indirect anticoagulants, fibrinolytics can enhance their therapeutic effect.
The interaction of the ointment for external use with other medicinal substances / preparations has not been identified.
Analogs
Artradol's analogues are Chondrolone, Khonsurid, Chondroitin sulfate, Alflutop, Chondroguard, Chondroitin, Artogistan, Artra Chondroitin, Artravir-Inkampharm, Artrafik, Mucosat, Chondroxide.
Terms and conditions of storage
Keep out of the reach of children.
Store in a dark place. Storage temperature: lyophilisate - up to 25 ° C; ointment - from 2 to 20 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Lyophilisate is available by prescription, ointment is available without a prescription.
Reviews about Artradol
Numerous reviews about Artradol are positive. The effectiveness of the drug is confirmed by both patients and doctors. There are often reports that the use of the drug significantly reduces the pain syndrome already during the first course of therapy for intervertebral osteochondrosis and other degenerative-dystrophic pathologies of the spine. Patients note a decrease in edema in arthrosis of the joints, osteochondrosis and good tolerance of chondroitin sulfate.
Very rarely, against the background of the use of the drug, hemorrhages occur at the injection sites and minor allergic reactions.
The price of Artradol in pharmacies
The price of Artradol lyophilisate for the preparation of a solution for intramuscular injection for a package containing 10 ampoules can range from 689 rubles, the cost of the ointment is unknown today due to its absence in pharmacies.
Artradol: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Artradol lyoph. for prig of solution for intramuscular injection. 100mg 10 pcs. 664 RUB Buy |
|
Artradol 100 mg lyophilisate for the preparation of a solution for intramuscular administration 2 ml 10 pcs. 664 RUB Buy |
|
Artradol lyoph. for prig Solution for intramuscular injection. 100mg amp. 20 pcs. 1212 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
