ArtroKam - Instructions For Use, Indications, Doses

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

ArtroCam

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Terms and conditions of storage

ArtroKam is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory effects.

Release form and composition

Dosage form - film-coated tablets: white, round biconvex with a white or almost white core (10 pcs. In a blister strip, in a cardboard box 2, 5 or 10 packs; 50 or 100 pcs. In a polymer or in a glass jar or a polymer bottle, in a cardboard box 1 can or bottle).

The active ingredient of ArtroCam is ibuprofen, in 1 tablet - 0.2 g or 0.4 g.

Excipients: croscarmellose sodium, lactose (milk sugar), microcrystalline cellulose, potato starch "Extra", medium molecular weight povidone, magnesium stearate.

Shell composition: hypromellose, titanium dioxide, medium molecular weight povidone, polysorbate, talc.

Indications for use

• radiculitis;
• neuralgia;
• myalgia;
• rheumatoid arthritis;
• arthritis with gout;
• psoriatic arthritis;
• osteoarthritis;
• ankylosing spondylitis (ankylosing spondylitis);
• tendovaginitis;
• bursitis;
• inflammation of soft tissues after injury;
• toothache;
• pain syndrome after surgery, including surgery in dentistry;
• algodismenorrhea;
• inflammatory processes in the small pelvis;
• feverish conditions with colds and flu.

Contraindications

• incomplete or complete syndrome of intolerance to acetylsalicylic acid (urticaria, bronchial asthma, rhinosinusitis, polyps of the nasal mucosa);
• history of hypersensitivity to acetylsalicylic acid or other NSAIDs (including rhinitis, attacks of bronchial obstruction, urticaria);
• exacerbation of erosive and ulcerative pathologies of the gastrointestinal tract (GIT), including gastric ulcer and duodenal ulcer, ulcerative colitis, Crohn's disease;
• lactase deficiency (lactose intolerance);
• hemorrhagic diathesis, hemophilia, hypocoagulation and other diseases associated with bleeding disorders;
• intracranial hemorrhage, gastrointestinal bleeding;
• condition after coronary artery bypass grafting;
• active liver disease, liver failure;
• confirmed hyperkalemia;
• severe renal failure;
• progressive kidney disease;
• the period of pregnancy and breastfeeding;
• age up to 12 years;
• individual intolerance to the components of the drug.

It is recommended to prescribe ArthroCam with caution in case of arterial hypertension, heart failure, coronary heart disease, cerebrovascular pathologies, peripheral arterial diseases, diabetes mellitus, dyslipidemia, liver cirrhosis with portal hypertension, nephrotic syndrome, renal and / or hepatic failure, hyperbilirubinemia, blood etiologies, anemia, leukopenia, alcohol abuse, smoking, a history of gastritis, gastric ulcer and duodenal ulcer, enteritis, colitis; with concomitant therapy of severe somatic diseases with warfarin, other anticoagulants, oral glucocorticosteroids (including prednisolone), antiplatelet agents (including clopidogrel, acetylsalicylic acid), selective serotonin reuptake inhibitors (paroxetine,citalopram, fluoxetine, sertraline and others); elderly patients.

Method of administration and dosage

The tablets are taken orally with plenty of water.

The doctor prescribes the dosage regimen individually, based on clinical indications.

For treatment, the minimum effective dose should be established with the shortest possible course duration.

Recommended dosage: initial dose - 0.2 g 3-4 times a day. For a faster achievement of a therapeutic effect, the dose can be increased to 0.4 g 3 times a day. After achieving the desired clinical effect, the dose is reduced to 0.6-0.8 g per day. The course of treatment is no more than 7 days.

The maximum single dose for adults is 0.8 g, the daily dose is 1.2 g.

If the symptoms of the disease persist after 2-3 days of therapy, the drug should be discontinued and consult a doctor.

Patients with impaired renal or hepatic function, heart pathologies require dose reduction.

Side effects

• cardiovascular system: increased blood pressure (BP), tachycardia, heart failure;
• hepatobiliary system: hepatitis;
• gastrointestinal tract: NSAID gastropathy (nausea, vomiting, abdominal pain, diarrhea, heartburn, loss of appetite, constipation, flatulence; rarely - ulceration of the gastrointestinal tract mucosa up to perforation and bleeding), pain in the mouth, dryness or irritation of the oral mucosa, aphthous stomatitis, ulceration of the gum mucosa, pancreatitis;
• urinary system: nephrotic syndrome (edema), cystitis, allergic nephritis, polyuria, acute renal failure;
• respiratory system: bronchospasm, shortness of breath;
• organ of vision: dryness and irritation of the eyes, toxic damage to the optic nerve, double vision or blurred vision, edema of the conjunctiva and eyelids (allergic genesis), scotoma;
• sensory organs: ringing or tinnitus, hearing loss;
• nervous system: insomnia, headache, anxiety, dizziness, nervousness, irritability, confusion, psychomotor agitation, hallucinations, depression, drowsiness; rarely - aseptic meningitis (more often with autoimmune pathologies);
• allergic reactions: pruritus, rash (usually urticarial or erythematous), bronchospasm, allergic rhinitis, dyspnea, fever, Quincke's edema, exudative erythema multiforme (including Stevens-Johnson syndrome), anaphylactic shock, anaphylactoid reactions, non-eosinophilic syndrome Lyell);
• hematopoietic system: hemolytic, aplastic and other forms of anemia, leukopenia, thrombocytopenia, agranulocytosis, thrombocytopenic purpura;
• laboratory parameters: it is possible - an increase in the duration of bleeding, a decrease in the level of glucose concentration in the blood serum, a decrease in creatinine clearance, a decrease in the level of hematocrit and hemoglobin, an increase in the activity of liver enzymes, an increase in the serum concentration of creatinine.

The appearance of these undesirable effects is the basis for immediate discontinuation of the pills and a visit to a doctor.

special instructions

Long-term use of high doses of ArtroCam increases the risk of developing gastrointestinal, uterine, hemorrhoidal bleeding, bleeding of the gums, ulceration of the gastrointestinal tract mucosa, scotoma, color vision disorders, optic nerve damage.

Long-term use must be accompanied by regular monitoring of the peripheral blood picture, liver and kidney function.

The drug should be discontinued if symptoms of liver damage develop (nausea, vomiting, yellowing of the skin, skin itching, abdominal pain, increased liver enzymes, darkened urine) and consult a doctor.

Care should be taken to prescribe the drug to infected patients, since ibuprofen is able to mask subjective and objective signs of infection.

It is necessary to carefully monitor the condition of patients with symptoms of gastropathy: conduct a blood test with the determination of hematocrit and hemoglobin, analysis of feces for occult blood, esophagogastroduodenoscopy.

During the period of treatment, the use of alcoholic beverages and ethanol-containing drugs is contraindicated.

ArthroCam has a negative effect on the fertility of women, therefore it is not recommended to take it when planning a pregnancy.

When prescribing an analysis for the determination of 17-ketosteroids, taking the tablets should be discontinued 48 hours before the study.

During the period of treatment, it is necessary to refrain from driving vehicles and mechanisms, other types of activities, the implementation of which requires increased attention, quick mental and motor reactions.

Drug interactions

Ibuprofen is not recommended to be combined with acetylsalicylic acid and other NSAIDs. Since the drug reduces the antiplatelet and anti-inflammatory effect of acetylsalicylic acid, in patients taking acetylsalicylic acid as an antiplatelet agent, the combination can cause the development of acute coronary insufficiency.

With simultaneous therapy with ArthroCam:

• alteplase, streptokinase, urokinase (anticoagulants and thrombolytics) - increase the risk of bleeding;
• fluoxetine, citalopram, paroxetine, sertraline (serotonin reuptake inhibitors) - increase the risk of gastrointestinal bleeding;
• antihypertensive drugs - reduce their effectiveness;
• phenytoin, digoxin, lithium - can increase the level of concentration in the blood plasma while taking ibuprofen;
• valproic acid, cefamandol, cefotetan, cefoperazone, plikamycin - increase the likelihood of hypoprothrombinemia;
• gold preparations, cyclosporine - contribute to an increase in nephrotoxicity, since ibuprofen enhances the effect on prostaglandin synthesis in the kidneys;
• ethanol, phenytoin, barbiturates, tricyclic antidepressants, rifampicin, phenylbutazone (inducers of microsomal oxidation) - causing an increase in the production of hydroxylated active metabolites, increase the risk of severe intoxication;
• tubular secretion blockers - increase the concentration of ibuprofen in plasma;
• cyclosporine - increases its concentration in plasma;
• inhibitors of microsomal oxidation - reduce the hepatotoxic effect of ibuprofen;
• vasodilators - reduce hypotensive activity;
• ethanol, mineralocorticoids, estrogens, glucocorticoids - enhance unwanted effects;
• oral hypoglycemic agents, insulin, sulfonylurea derivatives - enhance their effect (consideration should be given to the need for dose adjustment);
• antacids, cholestyramine - reduce absorption;
• indirect anticoagulants, antiplatelet agents, fibrinolytics - increase activity;
• hydrochlorothiazide, furosemide, uricosuric agents - reduce the effectiveness of the action;
• caffeine - helps to enhance the analgesic effect;
• zidovudine - increases the risk of hematomas and hemarthrosis in patients with HIV infection and hemophilia.

Terms and conditions of storage

Store in a dry place at temperatures up to 30 ° C. Keep out of the reach of children.

Shelf life is 2 years.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!