Tussin Plus - Instructions For Use, Price, Composition, Analogs Of Syrup

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Tussin plus

Tussin plus: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Tussin plus

ATX code: R05DA20

Active ingredient: guaifenesin + dextromethorphan (guaifenesin + dextromethorphan)

Manufacturer: Bio-Pharm, Inc. (USA), Sagmel, Inc. (USA)

Description and photo updated: 22.11.2018

Tussin plus is a combined antitussive drug with an expectorant effect.

Release form and composition

Dosage form Tussin plus - syrup: red-orange solution, transparent, with a slight cherry smell, without sediment and foreign particles (in a PET bottle 118 ml, in a cardboard box 1 bottle complete with a dosage cup).

Composition of Tussin plus (5 ml of syrup):

• active substances: guaifenesin - 100 mg, dextromethorphan hydrobromide - 10 mg;
• auxiliary components: citric acid, glycerol (anhydrous glycerin), flavoring agent, corn syrup, sodium saccharinate, sodium benzoate, levomenthol, cherry flavor, FD&C charming red dye, purified water.

Pharmacological properties

Pharmacodynamics

The expectorant effect of guaifenesin, the active component of Tussin plus, is due to the stimulation of secretory cells of the bronchial mucosa, producing neutral polysaccharides, depolymerization of acidic mucopolysaccharides, a decrease in viscosity and an increase in sputum volume, activation of the ciliary apparatus of the bronchi, facilitating the removal of sputum and facilitating the transition to an unproductive one.

Another active component of the drug, dextromethorphan hydrobromide, helps to suppress excessively intense afferent impulses from the mucous membrane of the respiratory tract, increase the cough threshold, and reduce the intensity of dry irritating cough. Due to the inhibition of the excitability of the cough center, dextromethorphan is able to suppress coughs of any origin. At the same time, the substance in therapeutic dosages does not have analgesic, narcotic and hypnotic effects.

The duration of the antitussive action is 5-6 hours.

Pharmacokinetics

After oral administration, after 25-30 minutes, guaifenesin is rapidly absorbed in the gastrointestinal tract. Its half-life (T _1/2) is 1 hour. The active substance is able to penetrate into tissues containing acidic mucopolysaccharides. Guaifenesin is metabolized in the liver. Excretion occurs through the lungs (with sputum) and in the form of inactive metabolites through the kidneys.

Dextromethorphan hydrobromide is rapidly absorbed from the gastrointestinal tract, after 15-30 minutes its effect begins to manifest itself. Metabolism occurs mainly with the participation of liver enzymes by O- and N-demethylation and partial binding with sulfates and glucuronic acid. In humans, (+) - 3-hydroxymorphinan, (+) - 3-hydroxy-1H-methylmorphinan and traces of an unmetabolized substance after oral administration can be observed in urine.

Indications for use

According to the instructions, Tussin plus is indicated for use in colds, flu, acute respiratory viral infections, accompanied by a cough.

Contraindications

Absolute:

• peptic ulcer of the stomach and duodenum;
• gastric bleeding (in history);
• severe organic diseases of the central nervous system;
• moist cough with profuse expectoration;
• concomitant use of drugs that include guaifenesin and / or dextromethorphan;
• children under 6 years old;
• increased individual sensitivity to any component in the composition of Tussin plus.

Relative (use of the drug requires caution):

• impaired renal and / or liver function;
• bronchial asthma;
• pregnancy and lactation period.

Instructions for the use of Tussin plus: method and dosage

Tussin plus syrup is taken orally, after meals, using a dosage cup or teaspoon.

Recommended dosage regimen:

• adults and children over 12 years old: two teaspoons every 4 hours;
• children from 6 to 12 years old: one teaspoon every 4 hours.

Side effects

During the period of treatment with the drug, the following side reactions may occur: nausea, vomiting, dyspeptic disorders, diarrhea, exacerbation of gastric and duodenal ulcers, headache, dizziness, insomnia or drowsiness, increased excitability (especially in children), allergic reactions in the form of skin rash, urticaria, hyperthermia.

Overdose

Especially high doses of guaifenesin can cause nausea and vomiting. In case of prolonged vomiting, it is necessary to carry out measures to replenish fluid in the body and control the level of electrolytes.

An overdose of dextromethorphan can lead to the development of dizziness, agitation, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

In case of an overdose of Tussin plus, gastric lavage, intake of activated charcoal, and symptomatic therapy are recommended.

special instructions

During the period of drug treatment, a sufficient amount of liquid should be taken.

During the application of Tussin plus, urine may turn pink.

When testing the content of 5-hydroxyindoleacetic acid in urine (using a nitrosonaphthol reagent), the result may be falsely overestimated due to the effect of guaifenesin metabolites on urine color. The drug must be discontinued 2 days before urine collection for this analysis.

Guaifenesin and its metabolites can also change color when determining the concentration of vanillyl mandelic acid in urine and cause a false overestimation of the results of the analysis with it for catechins. Stop taking guaifenesin 2 days before urine collection for this test.

A dosage cup is included with Tussin plus. One division of TSP equals 5 ml - one teaspoon.

Influence on the ability to drive vehicles and complex mechanisms

Since while taking the drug, side effects such as dizziness and drowsiness are possible, care must be taken when driving or performing any activities that require a quick psychomotor reaction and high concentration of attention.

Application during pregnancy and lactation

Tussin plus should be prescribed to pregnant and breastfeeding women with caution and in the case when the expected benefit to the mother is higher than the potential risk to the fetus / child.

Pediatric use

The use of the drug in children under 6 years of age is contraindicated.

With impaired renal function

Patients with renal insufficiency should take Tussin plus with caution.

For violations of liver function

Liver dysfunction is a relative contraindication to the use of the drug.

Drug interactions

• bronchodilators, antimicrobials, cardiac glycosides: compatible with guaifenesin and dextromethorphan;
• antitussives (including those containing codeine), mucolytic drugs: simultaneous use with guaifenesin and dextromethorphan is not recommended;
• drugs that are inhibitors of monoamine oxidase (including selegiline, procarbazine, furazolidone): combined use with Tussin plus can cause dizziness, increased blood pressure, agitation, drowsiness, tremor, nausea, spasms, adrenergic crisis, coma, collapse, intracranial bleeding, hyperpyrexia;
• fluoxetine, amiodarone, quinidine and other inhibitors of the cytochrome P450 system: an increase in the concentration of the drug in the blood is possible;
• tobacco smoke: can lead to an increase in glandular secretion while suppressing the cough reflex.

Analogs

Analogs of Tussin plus are: Kodarin, Goikodin, Kodeterp, Kodepsin, Tedein, Terpinkod, Kodterpin, Kolelak and others.

Terms and conditions of storage

Store at a temperature between 8 and 25 ° C. Do not refrigerate.

Keep out of the reach of children.

Shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Tussin plus

Most of the reviews about Tussin Plus are positive. The main advantage of the drug is its speed, within 15–20 minutes after taking the syrup, its expectorant effect appears, the cough weakens and the patient's condition improves.

Users report that it is undesirable to allow an overdose of the drug, as in this case, side effects such as nausea and dizziness (up to a loss of consciousness) are likely.

The taste of the drug is controversial. Children tend to like the cherry flavor and syrup color.

Price for Tussin plus in pharmacies

The price for Tussin plus for a bottle of 118 ml is approximately 150 rubles.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!