Ubistezin forte
Ubistezin forte: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. In case of impaired liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Ubistesine forte
ATX code: N01BB58
Active ingredient: articaine + epinephrine (articaine + epinephrine)
Producer: 3M Deutschland GmbH (Germany)
Description and photo updated: 20.11.2018
Prices in pharmacies: from 2834 rubles.
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Ubistezin forte is a combined local anesthetic drug containing an anesthetic and a vasoconstrictor.
Release form and composition
Dosage form Ubistezina forte - solution for injection: transparent liquid without color (1.7 ml of solution in colorless glass cartridges, sealed on both sides with corks, 50 cartridges in a tin can).
Composition of 1 ml solution:
- active substances: articaine hydrochloride - 40 mg; epinephrine hydrochloride - 0.012 mg (which corresponds to 0.01 mg of epinephrine);
- auxiliary components: sodium sulfite, sodium chloride, water for injection.
Pharmacological properties
Pharmacodynamics
Ubistezin forte is a combined preparation for local anesthesia used in dentistry, the action of which is due to the properties of its constituent components:
- articaine: local anesthetic, amide type of thiaphene group. Begins to act within 1-3 minutes, the minimum time of anesthesia is 75 minutes, for soft tissues 120-240 minutes;
- epinephrine (adrenaline): a vasoconstrictor, constricts blood vessels at the injection site, ensures slow absorption of the drug, and prolongs its effect. When using Ubistezin forte, wound healing usually proceeds without complications.
Pharmacokinetics
The diffusion capacity of articaine is high. Protein binding - 95%. Metabolized in the liver. The half-life is 25 minutes. It is excreted mainly in the urine. The substance in minimal amounts overcomes the placental barrier and is practically not excreted during lactation.
Indications for use
According to the instructions, Ubistezin Forte is indicated for infiltration and conduction anesthesia, especially in patients with severe somatic diseases, for the following manipulations:
- uncomplicated extraction of one or more teeth;
- filling of carious cavities, preparation of teeth before prosthetics;
- surgical interventions on the mucous membranes of the oral cavity or on the bones, requiring a more pronounced decrease in blood supply (the effect of ischemia);
- sinusitis according to Caldwell - Luke;
- percutaneous osteosynthesis.
Contraindications
Absolute contraindications:
- deficiency of cholinesterase activity;
- hemorrhagic diathesis;
- porphyria;
- hyperthyroidism;
- severe liver failure;
- angle-closure glaucoma;
- severe heart disease (uncontrolled congestive heart failure, unstable angina pectoris, condition after a recent myocardial infarction or coronary artery bypass grafting, severe uncontrolled arterial hypertension, hypotension, tachyarrhythmia, severe cardiac conduction disturbances);
- bronchial asthma with hypersensitivity to sulfites;
- inflammation at the site of planned anesthesia;
- cardiogenic shock;
- age up to 4 years;
- hypersensitivity to drug components and other sulfites.
Relative contraindications (Ubistezin forte is used with extreme caution):
- blood clotting disorders;
- pheochromocytoma;
- diabetes;
- epilepsy;
- bronchial asthma;
- heart disease (arterial hypertension, atherosclerosis, chronic heart failure, atrioventricular and intraventricular block I degree);
- hepatic / hepatic impairment;
- elderly age;
- weakened and severe general condition of the patient.
Instructions for the use of Ubistezin forte: method and dosage
Ubistezin forte is administered parenterally. Intravenous (IV) administration of the drug, as well as injection at the site of inflammation, is unacceptable.
For uncomplicated tooth extraction, 1 dose of the drug (1.7 ml) is usually sufficient for each tooth injected into the submucosa in the region of the transitional fold from the vestibular side. In some cases, to achieve complete anesthesia, additional administration of 1 to 1.7 ml of the drug is possible.
In preparation for filling or installing a crown, 0.5-1.7 ml of the drug is injected (depending on the desired depth and duration of the procedure) by the type of infiltration anesthesia from the vestibular side. For palatal anesthesia, 0.1 ml of the drug is usually sufficient.
For the removal of the lower premolars, infiltration anesthesia with 1.7 ml of Ubistezine Forte is usually recommended per tooth, which avoids mandibular anesthesia. If necessary, it is allowed to additionally inject 1–1.7 ml of the drug into the submucosa in the region of the transitional fold of the lower jaw from the vestibular side. If complete anesthesia cannot be achieved, it is advisable to perform a mandibular nerve block.
The maximum allowable dose of Ubistezine Forte is 7 mg of articaine per 1 kg of body weight (1 ml of solution contains 40 mg of articaine).
Side effects
- central nervous system (CNS): headache; muscle tremors and / or muscle twitching, up to generalized seizures; respiratory failure, up to a stop; violation of consciousness, up to its loss;
- digestive organs: nausea, vomiting, diarrhea;
- organ of vision: blurred eyes, transient blindness, diplopia;
- cardiovascular system: hemodynamic disorders [decrease or increase in blood pressure (BP), bradycardia, tachycardia, arrhythmia], suppression of cardiovascular activity, up to collapse and cardiac arrest;
- allergic reactions: edema and inflammation at the injection site, itching of the conjunctiva, redness and itching, angioedema, anaphylactic shock.
At the site of administration of Ubistezin forte, ischemic zones may appear, and with accidental intravascular administration, tissue necrosis is likely to develop.
Overdose
Symptoms of an Ubistezine Forte overdose are dizziness, impaired consciousness, motor restlessness, lowering blood pressure, tachycardia, bradycardia.
When symptoms of an overdose appear, the injection must be stopped immediately, the patient must be given a horizontal position, and the airway must be free. Blood pressure and heart rate (HR) should be kept under control.
Recommendations for symptomatic treatment of overdose:
- breathing disorder: oxygen, endotracheal intubation, artificial ventilation of the lungs (central analeptics are contraindicated);
- convulsions: shown in / in the slow administration of short-acting barbiturates, oxygen, hemodynamic control;
- severe circulatory disorders, shock: intravenous infusion solution of electrolytes, plasma substitutes, glucocorticosteroids, albumin;
- vascular collapse and increasing bradycardia: IV, and then IV drip epinephrine (initial dose - 0.1 mg), control of heart rate and blood pressure;
- severe tachycardia and tachyarrhythmia: intravenous selective beta-blockers;
- increased blood pressure: peripheral vasodilators.
special instructions
The sulfites contained in the drug can enhance the anaphylactic reaction.
Eating after the completion of surgical procedures is recommended after the restoration of sensitivity.
Use only new and sterile syringes and needles each time you draw up solution. An open cartridge should not be reused due to the risk of hepatitis infection. It is also unacceptable to use the drug from a damaged cartridge.
Influence on the ability to drive vehicles and complex mechanisms
Due to preoperative anxiety and stress, the doctor makes a decision on admitting a patient to drive vehicles and other complex mechanisms on an individual basis.
Application during pregnancy and lactation
Due to the lack of data on the safety of the use of Ubistezine forte during pregnancy, it is possible only when the expected benefit to the mother outweighs the possible risk to the fetus.
It is also unknown whether articaine and epinephrine are excreted in breast milk, and therefore requires a careful assessment of the benefit / risk ratio when deciding whether to continue breastfeeding while using the drug.
In the case when it is decided to continue lactation after anesthesia with Ubistezin Forte, it is recommended to skip one feeding, replacing it with an artificial one, while milk should be expressed and not used.
Pediatric use
Recommendations for dosage of the drug in children aged 4 to 18 years, depending on body weight:
- 20-30 kg: 0.25-1 ml;
- 30–45 kg: 0.5–2 ml.
Recommended maximum daily dose, depending on body weight:
- 20-30 kg: 3.5 ml;
- 30-40 kg: 5.25 ml;
- 40–45 kg: 7.0 ml;
- 45-50 kg: 7.9 ml;
- 50-60 kg: 8.7 ml;
- 60–70 kg: 10.5 ml;
- 70-80 kg: 12.2 ml.
In children, infiltration anesthesia may be used instead of conduction anesthesia, due to the lower bone density.
With impaired renal function
Patients with impaired renal function may need to reduce the dose of Ubistezine forte to achieve a sufficient depth of anesthesia and systemic accumulation.
If liver function is impaired
Patients with impaired liver function may need to reduce the dose of the drug to achieve a sufficient depth of anesthesia and systemic accumulation.
Use in the elderly
Elderly patients with diseases of the heart and liver require a reduction in the dose of Ubistezine forte in order to reduce the risk of its cumulation upon repeated administration.
Drug interactions
The use of Ubistezine forte in conjunction with non-selective beta-blockers, monoamine oxidase inhibitors and tricyclic antidepressants is contraindicated.
It is recommended to use the drug with caution in combination with phenothiazine, anticoagulants, antiplatelet agents, cardioselective beta-blockers.
Vasoconstrictor drugs enhance and lengthen the local anesthetic effect of articaine.
Analogs
Analogues of Ubistezin Forte are Alfakain SP, Articaine, Artifrin, Brilocaine, Orablok, Primacaine with adrenaline, Ubistezin, Ultracaine, Cytokartin.
Terms and conditions of storage
Store away from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ubistezin Fort
Reviews about Ubistezine Fort on the network are mostly positive. Its reliable action is noted.
Among the disadvantages, as a rule, indicate the high cost of the drug and the presence of contraindications.
Price for Ubistezin forte in pharmacies
The approximate price for Ubistezin forte is 2530 rubles. for 1 tin can containing 50 cartridges.
Ubistezin forte: prices in online pharmacies
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Drug name Price Pharmacy |
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Ubistezin forte 40 mg + 10 μg / ml solution for injection with epinephrine 1.7 ml 50 pcs. 2834 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
