Protein bacteriophage
Protein bacteriophage: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Bacteriophagum proteicum
ATX code: V03A
Active ingredient: sterile filtrate of phagolysates bacteria Proteus vulgaris and Proteus mirabilis
Manufacturer: FSUE NPO Microgen (Russia)
Description and photo update: 2019-24-01
Proteus bacteriophage - medical immunobiological drug (MIBP), bacteriophage for the treatment of diseases caused by Proteus bacteria.
Release form and composition
Dosage form - solution for oral administration, local and external use: transparent yellow liquid of various saturation with a possible greenish tinge (20 ml in a bottle, 4 or 10 bottles in a cardboard box; 100 ml in a bottle, 1 bottle in a cardboard box; each the pack also contains instructions for the use of Protein Bacteriophage).
1 ml of solution contains:
- active substance: sterile purified filtrate of phagolysates of bacteria Proteus mirabilis and Proteus vulgaris (with an activity according to the Appelman method not less than 10 -5) - up to 1 ml;
- additional component (preservative): 8-hydroxyquinoline sulfate monohydrate, in terms of 8-hydroxyquinoline sulfate - 0.000 1 g / ml (calculated content).
Pharmacological properties
Pharmacodynamics
The drug demonstrates the ability to specifically lyse (dissolve the cell wall) Proteus bacteria.
Indications for use
Protein bacteriophage is recommended for the prevention and treatment as part of the complex therapy of enteral and pyoinflammatory diseases excited by the bacteria P. mirabilis and P. vulgaris:
- suppuration of wounds, abscess, burns, phlegmon, carbuncles, boils, panaritiums, hydradenitis, paraproctitis, bursitis, mastitis, osteomyelitis and other surgical infections;
- inflammation of the middle ear, sinuses, laryngitis, pharyngitis, tonsillitis, tracheitis, pneumonia, bronchitis, pleurisy and other lesions of the lungs, respiratory tract and ENT organs;
- cystitis, urethritis, pyelonephritis, endometritis, colpitis, salpingo-oophoritis and other urogenital infections;
- generalized septic diseases;
- intestinal dysbiosis, enteric infections, including gastroenterocolitis and cholecystitis;
- purulent-inflammatory diseases of newborns, such as pyoderma, omphalitis, conjunctivitis, sepsis, etc.;
- other diseases caused by Proteus bacteria.
For prophylaxis, Protein Bacteriophage solution is used to treat wounds (freshly infected and postoperative), as well as for epidemic indications to prevent nosocomial infections.
To increase the effect of drug therapy, a preliminary determination of the phagosensitivity of the pathogen is of great importance.
Contraindications
Contraindication for the use of Protein Bacteriophage is the presence of hypersensitivity to its components.
Protein bacteriophage, instructions for use: method and dosage
Protein Bacteriophage solution is used for oral administration, rectal administration, in the form of applications, irrigation, for introduction into the nasal cavity, paranasal sinuses, in the vagina, uterus, wounds and drained cavities.
The recommended single doses of Protein Bacteriophage, taking into account the patient's age, for oral administration / rectal administration (using an enema):
- 0-6 months: 5 ml / 5-10 ml;
- 6-12 months: 10 ml / 10-20 ml;
- from 1 to 3 years: 15 ml / 20-30 ml;
- from 3 to 8 years old: 15–20 ml / 30–40 ml;
- 8 years and older: 20-30 ml / 40-50 ml.
Against the background of purulent-inflammatory diseases with localized lesions, the drug is indicated to be used simultaneously orally and locally, the course of therapy in this case depends on clinical indications and can be 7–20 days.
The wound must be thoroughly washed with a sterile solution of sodium chloride 0.9%, if it was treated with chemical antiseptics before the appointment of the bacteriophage.
Recommended methods of application and doses of Protein Bacteriophage, depending on the location of the focus of infection:
- cystitis, urethritis, pyelonephritis: administered orally; if the cavity of the renal pelvis or bladder is drained, the solution is injected 1-2 times a day using a nephrostomy or cystostomy at a dose of 5–7 ml into the renal pelvis and at a dose of 20–50 ml into the bladder;
- infectious lesions of the articular, pleural or other limited cavities: injections are carried out in a dose of up to 100 ml and a capillary drainage is left, through which the solution is re-injected over several days;
- surgical infections: used in the form of lotions, irrigation and tamponing at a dose of up to 200 ml, taking into account the size of the affected area; with an abscess after opening the cavity and removing its purulent contents Protein bacteriophage is injected by puncture in a volume less than the amount of removed pus; in the treatment of osteomyelitis after surgical treatment of the wound, a solution is poured into it in a dose of 10–20 ml;
- diseases of the ear, throat, nose of a purulent-inflammatory nature: prescribed 1-3 times a day at a dose of 2-10 ml; used in the form of instillations, rinsing, rinsing and injections impregnated with the drug turunda, laying them for 1 hour;
- enteric infections, intestinal dysbiosis: taken orally 3 times a day 1 hour before meals for 7-20 days in accordance with clinical indications; oral administration of Protein Bacteriophage is allowed 2 times a day in combination with 1 rectal administration of bacteriophage after emptying the intestines in the form of an enema in a single age dose;
- purulent-inflammatory gynecological lesions: use daily, injecting 1 time per day at a dose of 5-10 ml into the uterine cavity, vagina; with colpitis, irrigation or tamponing at a dose of 10 ml is performed 2 times a day, laying tampons for 2 hours.
Recommended dosage regimen of Protein Bacteriophage in children under 6 months:
- treatment of omphalitis, pyoderma, infected wounds: use daily 2 times a day in the form of applications - a gauze napkin soaked in solution is applied to the affected area or umbilical wound;
- treatment of enterocolitis, sepsis of newborns (including premature infants): the drug is prescribed 2-3 times a day through a gas tube or catheter (in the form of high enemas) in a dose of 5-10 ml; oral administration is also possible in the absence of regurgitation and vomiting, in this case the drug is mixed with breast milk; the combined administration of a bacteriophage can also be prescribed - orally and rectally (in the form of high enemas), the course of therapy is from 5 to 15 days; against the background of a recurrent course of the disease, at the discretion of the doctor, it is allowed to reuse Proteus Bacteriophage;
- prevention of enterocolitis and sepsis in case of intrauterine infection or the threat of nosocomial infection in newborns: use 2 times a day in the form of enemas for 5-7 days.
Side effects
The occurrence of side effects against the background of the use of Protein Bacteriophage has not been established.
Overdose
Overdose cases were not recorded.
special instructions
The bottle with the solution must be shaken before use, only a transparent and sediment-free preparation can be used.
Since the bacteriophage contains a nutrient medium that is favorable for the development of bacteria living in the environment, the latter can penetrate into the preparation and cause it to become cloudy. In connection with this possibility, it is necessary to strictly observe the following rules when opening the bottle:
- wash your hands well;
- treat the cap before removing it with a solution containing alcohol;
- remove the cap without removing the plug;
- remove the plug, avoiding contact of its inner side with any surface;
- do not leave the bottle with the solution open;
- keep the opened bottle always in the refrigerator.
It is possible to open the bottle and further extract the required dose of the drug using a sterile syringe, by piercing the cork with a needle.
If the recommended storage conditions are observed and the above rules are followed, the solution after opening the bottle can be used throughout the entire shelf life. It is prohibited to use the opaque drug!
Influence on the ability to drive vehicles and complex mechanisms
There is no data on the possible effect of Protein Bacteriophage on the ability to control complex mechanisms, including vehicles.
Application during pregnancy and lactation
In pregnant and breastfeeding women, the use of Protein Bacteriophage for the treatment of infectious lesions excited by phage-sensitive bacterial strains is possible only on the recommendation of the attending physician.
Pediatric use
There are no age restrictions for using the bacteriophage.
Drug interactions
Protein bacteriophage can be used in combination therapy with other drugs / substances, including antibacterial drugs.
Analogs
There is no information about analogues of Protein Bacteriophage.
Terms and conditions of storage
Store at 2–8 ° C in a place protected from light. Keep out of the reach of children.
Recommended temperature during transportation is 2–8 ° C, transportation is allowed at a temperature of 9–25 ° C, but for no more than 30 days.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Bacteriophage Protein
There are few reviews about Protein Bacteriophage, mostly they belong to the parents of young patients, who in most cases consider the drug to be an effective remedy used in the complex therapy of enteral and purulent-inflammatory diseases caused by Proteus bacteria. To improve the results of treatment, it is recommended to carry out a preliminary diagnosis of the phage sensitivity of the pathogen.
There are no complaints about the development of side effects, many patients note the absence of the drug on sale.
Price for Protein Bacteriophage in pharmacies
The reliable price of Protein Bacteriophage is unknown, since it is not currently sold in pharmacies.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
