Bacteriophage Pseudomonas Aeruginosis (Pseudomonas Aeruginosa) - Instructions For Use

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa)

Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa): instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Bacteriophage Pseudomonas aeruginosa fluid

ATX code: V03A

Active ingredient: bacteriophage of Pseudomonas aeruginosa (Bacteriophagum Pseudomonas aeruginosa)

Manufacturer: Microgen NPO, JSC (Russia)

Description and photo update: 2019-09-07

Prices in pharmacies: from 626 rubles.

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The bacteriophage pseudomonas aeruginosa (Pseudomonas aeruginosa) is a drug that has a specific antibacterial effect against Pseudomonas aeruginosa bacteria.

Release form and composition

The dosage form of the drug is a solution for oral administration, local and external use: transparent yellow liquid of varying intensity, may have a greenish tint [20 and 100 ml in vials, in a cardboard box 1 bottle of 100 ml, 4 or 8 vials of 20 ml and instructions for the use of Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa)].

Composition of 1 ml solution:

• active substance: sterile purified filtrate of Pseudomonas aeruginosa bacterial phagolysates (with an Appelman activity of at least 10 ^-5) - up to 1 ml;
• auxiliary component: preservative - 8-hydroxyquinoline sulfate monohydrate (calculated as 8-hydroxyquinoline sulfate, calculated content) or 8-hydroxyquinoline sulfate (calculated content) - 0.000 1 g / ml.

Pharmacological properties

Pharmacodynamics

The drug causes specific lysis of P. aeruginosa bacteria (Pseudomonas aeruginosa).

Pharmacokinetics

No information available.

Indications for use

The bacteriophage pseudomonas aeruginosa (Pseudomonas aeruginosa) is used for prophylaxis and treatment as a monopreparation or as part of a complex therapy of the following diseases caused by P. aeruginosa bacteria:

• intestinal dysbiosis, enteral infections (cholecystitis, gastroenterocolitis), generalized septic diseases;
• urogenital infections (colpitis, salpingo-oophoritis, endometritis, urethritis, pyelonephritis, cystitis);
• surgical infections (carbuncles, boils, phlegmon, abscess, panaritium, hydradenitis, burns, wound suppuration, bursitis, mastitis, paraproctitis, osteomyelitis);
• diseases of the ear, throat, nose, respiratory tract and lungs (tracheitis, laryngitis, pharyngitis, tonsillitis, inflammation of the sinuses of the nose and middle ear, pleurisy, bronchitis, pneumonia);
• purulent-inflammatory diseases of newborns (including conjunctivitis, pyoderma, gastroenterocolitis, omphalitis, sepsis);
• other diseases caused by Pseudomonas aeruginosa.

In order to prevent bacteriophage used for epidemic indications for the prevention of nosocomial infections, for the treatment of freshly infected and postoperative wounds.

Contraindications

The bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa) is contraindicated only in case of individual sensitivity to the drug.

Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa), instructions for use: method and dosage

The agent is used orally, rectally, in the form of irrigation and applications, for introduction into drained cavities, in the uterus, vagina, wounds, nose and sinuses. Before use, the bottle must be shaken and inspected for turbidity and sediment.

Recommended single doses of bacteriophage, depending on the patient's age, for oral administration:

• 0-6 months - 5 ml;
• 6-12 months - 10 ml;
• from 1 to 3 years old - 15 ml;
• from 3 to 8 years old - 15–20 ml;
• 8 years and older - 20-30 ml.

Recommended single dosages of bacteriophage, depending on the patient's age, for rectal administration:

• 0-6 months - 5-10 ml;
• 6-12 months - 10-20 ml;
• from 1 to 3 years - 20-30 ml;
• from 3 to 8 years old - 30-40 ml;
• 8 years and older - 40-50 ml.

In case of purulent-inflammatory diseases with localized lesions, treatment should be carried out with the simultaneous use of the drug locally and inside 2-3 times a day 1 hour before meals. You need to start therapy from the first day of the disease and continue for 7–20 days, depending on clinical need. If chemical antiseptics were used to treat wounds before the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.

Dosage regimen and methods of application of Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa), depending on the focus of infection:

• irrigation, lotions, plugging: based on the size of the affected area, the volume of the drug can be up to 200 ml. With an abscess, a bacteriophage is injected after removal of purulent contents by puncture in a smaller amount than the volume of removed pus. In osteomyelitis, the solution is poured into the wound in an amount of 10–20 ml after appropriate surgical treatment;
• introduction into limited cavities (including into the articular and pleural): the amount of bacteriophage is up to 100 ml, then the capillary drainage is left and the drug is continued to be administered through it for several days;
• introduction into the cavity of the vagina and uterus for purulent-inflammatory gynecological diseases: 5-10 ml 1 time per day daily;
• rinsing, instillation, rinsing, introduction of moistened turundas for purulent-inflammatory diseases of the ear, throat, nose: 2-10 ml from 1 to 3 times a day. Moistened turundas after administration are left for 1 hour;
• introduction through a cystostomy or nephrostomy for cystitis, pyelonephritis, urethritis: into the bladder - 20-50 ml 1-2 times a day, into the renal pelvis - 5-7 ml 1-2 times a day. If the cavity of the bladder or renal pelvis is not drained, the bacteriophage is prescribed internally;
• inside / rectally for intestinal dysbiosis and enteral infections: inside 1 hour before meals 3 times a day. You can combine oral administration 2 times a day and rectal administration 1 time per day for 1 age dose in the form of an enema after bowel movement.

Application of bacteriophage in children (up to 6 months)

In newborns (including premature infants) with sepsis and enterocolitis Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa) is used through a catheter or a gas outlet tube in the form of high enemas. The recommended dose is 5-10 ml, the frequency of procedures is 2-3 times a day.

If the child does not spit up, he does not vomit, you can give the bacteriophage inside through the mouth. In this case, the solution is best mixed with breast milk / infant formula.

A combination of rectal and oral administration of the drug is allowed.

The duration of treatment is from 5 to 15 days. In the case of diseases with a recurrent course, repeated courses are carried out.

For the prevention of sepsis and enterocolitis with intrauterine infection or the presence of a risk of nosocomial infection in a newborn, the use of a bacteriophage rectally (in the form of enemas) 2 times a day for 5-7 days is indicated.

For infected wounds, pyoderma and omphalitis Bacteriophage pseudomonas aeruginosa (Pseudomonas aeruginosa) is used as applications 2 times a day. For this, a gauze napkin is moistened with a solution and applied to the affected area or umbilical wound.

Side effects

Until now, there have been no reports of the development of negative reactions during the period of drug therapy.

Overdose

There are no reports of drug overdose.

special instructions

For effective therapy, it is important to first determine the sensitivity of the pathogen to the drug and start treatment as early as possible.

In the nutrient medium of the bacteriophage, bacteria from outside can develop, causing the solution to become cloudy. In this regard, when opening the bottle, be sure to adhere to the following instructions:

1. Wash hands thoroughly.
2. Treat the cap with an alcohol solution.
3. Remove the cap from the bottle without opening the cap.
4. Draw up the solution with a sterile syringe by piercing the stopper.
5. If the cork comes off for any reason, do not place it on any objects with the inner surface.
6. Do not leave bottle open.
7. Store the opened bottle only in the refrigerator.

Subject to the recommendations for storage and the above rules for taking the solution, the drug can be used throughout the shelf life indicated on the bottle.

The bacteriophage must not be used if it becomes cloudy, the integrity or labeling of the package is violated, or the expiration date has expired.

Influence on the ability to drive vehicles and complex mechanisms

There are no data on the negative effect of the drug on the cognitive and psychophysical functions of a person.

Application during pregnancy and lactation

The bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa) can be used during pregnancy and lactation as prescribed by a doctor.

Pediatric use

There are no restrictions on the use of the drug in pediatrics.

Drug interactions

The bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa) can be combined with other drugs, including antibiotics.

Analogs

Analogues of Bacteriophage Pseudomonas aeruginosis (Pseudomonas aeruginosa) are: Dioxidin, Nitroxoline, Monural, Rowlin-Routek, Uronormin-F, Staphylococcal Bacteriophage, Amizolid, Uroxolin, Fosmural, Forteraz, Urofosfabol, etc.

Terms and conditions of storage

Store in a dark place at a temperature of 2-8 ° C (in the refrigerator). Keep out of the reach of children.

It is necessary to transport the drug at a temperature of 2–8 ° С. Transportation at a temperature of 9–25 ° C for 30 days (no more) is allowed.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa)

According to reviews, Bacteriophage pseudomonas aeruginosa (Pseudomonas aeruginosa) is an effective remedy for diseases caused by sensitive pathogens. The drug has a fast action, can be used in various ways, and is well tolerated. It can be used to treat babies from birth.

Price for Bacteriophage pseudomonas aeruginosa (Pseudomonas aeruginosa) in pharmacies

Depending on the region of sale and the pharmacy network, the price for Bacteriophage pseudomonas aeruginosa (Pseudomonas aeruginosa) for 1 bottle of 100 ml is 599–754 rubles, for 4 bottles of 20 ml - 570–650 rubles.

Bacteriophage pseudomonas aeruginosa (Pseudomonas aeruginosa): prices in online pharmacies

Drug name Price Pharmacy

Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa) solution for internal and external use 20 ml 4 pcs. 626 r Buy

Bacteriophage pseudomonas aeruginosis (Pseudomonas aeruginosa) liquid solution for topical use and oral administration 100 ml 1 pc. 1205 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!