Has
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Imet is a non-steroidal anti-inflammatory drug with analgesic and antipyretic properties.
Release form and composition
Dosage form - coated tablets (10 pcs. In blisters, in a cardboard box 1, 2 or 3 blisters).
The active substance is ibuprofen, in 1 tablet - 400 mg. Also included are auxiliary components.
Indications for use
The use of Imet is indicated for the symptomatic treatment of pain syndrome of weak and moderate intensity:
- Diseases of the musculoskeletal system: osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and other inflammatory and degenerative pathologies; psoriatic arthritis, articular syndrome with exacerbation of gout;
- Bursitis, tendovaginitis;
- Post-traumatic joint and muscle pain;
- Toothache and headache;
- Acute respiratory viral infections (as part of complex therapy);
- Algodismenorrhea, adnexitis;
- Feverish states of various origins.
Contraindications
- Severe renal and / or liver dysfunction;
- Severe cardiovascular insufficiency;
- Peptic ulcers, hemorrhages, including a history;
- Functional disorders of the hematopoietic system associated with a tendency to active bleeding, including gastrointestinal and cerebrovascular bleeding;
- Aspirin triad (in history);
- Simultaneous use of selective inhibitors of cyclooxygenase-2 or other non-steroidal anti-inflammatory drugs;
- Age under 12;
- III trimester of pregnancy;
- Hypersensitivity to drug components and other non-steroidal anti-inflammatory drugs.
It is recommended to prescribe with caution: elderly patients due to the increased risk of bleeding, including fatal ones; with systemic lupus erythematosus, arterial hypertension, mixed collagenosis, cardiovascular failure, impaired renal and liver function; in the I and II trimesters of pregnancy, during breastfeeding; immediately after surgery.
Method of administration and dosage
The tablets are taken orally, without chewing, during or immediately after a meal, with a sufficient amount of water.
The dose and duration of use is prescribed by the doctor individually, taking into account the clinical indications and the patient's condition.
Recommended daily dosage:
- Pain syndrome of mild to moderate intensity: 200-400 mg 2-3 times a day with an interval between doses of at least 4 hours;
- Feverish states of various origins: 200-400 mg 1 time per day, if necessary, repeated administration is allowed after 4 hours.
The maximum daily dose for patients over 15 years old is 1200 mg, for children over 12 years old - 1000 mg.
For elderly patients, dose adjustment is not required.
Side effects
- From the gastrointestinal tract: nausea, epigastric pain, vomiting, dry mouth, heartburn, flatulence, indigestion, diarrhea or constipation; possibly - ulcerative lesions of the stomach and duodenum (including perforation and bleeding), gastrointestinal bleeding, ulcerative stomatitis, exacerbation of colitis and Crohn's disease, esophagitis, gastritis, pancreatitis; in isolated cases - duodenitis;
- From the side of the cardiovascular system: heart failure, arrhythmia, arterial hypertension; possibly - the development of myocardial infarction (when taking high doses);
- From the nervous system: dizziness, headache, sleep disturbances, irritability, increased fatigue; perhaps - depression, emotional lability, a sense of causeless anxiety and other psychotic reactions; in isolated cases - convulsions, psychomotor agitation;
- From the hematopoietic system: thrombocytopenia, anemia, pancytopenia, agranulocytosis, leukopenia; in patients with impaired function of the hematopoietic system - erosive lesions of the oral mucosa, sore throat and / or muscles, fever, depression; possibly - hematomas, skin hemorrhages, nosebleeds and other bleeding of unknown etiology;
- From the hepatobiliary system: functional liver disorders, toxic liver damage, hepatitis, acute liver failure, hepatorenal syndrome;
- From the senses: visual impairment (with prolonged use), including dryness of the mucous membrane and color perception of the eye, decreased vision clarity; possibly - hearing impairment, tinnitus;
- From the genitourinary system: edema (mainly in patients with arterial hypertension and / or renal failure), renal papillary necrosis, interstitial nephritis, hyperuricemia, nephrotic syndrome, polyuria, cystitis, oliguria; in isolated cases - hematuria, glomerulonephritis;
- Allergic reactions: itching, skin rash, rhinitis, erythema multiforme, urticaria, anaphylactoid reactions, including swelling of the tongue and larynx, arterial hypotension, anaphylactic shock; possibly - the development of bronchospasm and bronchial asthma in patients with increased individual sensitivity;
- On the part of the skin: dry skin, Stevens-Johnson syndrome, alopecia, Lyell's syndrome, photosensitivity;
- Others: arterial thromboembolism, stroke (with prolonged use in high doses).
In addition, the undesirable effects of using Imet can be an exacerbation or development of infectious diseases: necrotizing fasciitis, aseptic meningitis (symptoms - stiff neck, hyperthermia, nausea, headache, vomiting, impaired consciousness).
special instructions
Elderly patients at the beginning of treatment should be prescribed a minimum single dose, if necessary and normal tolerance of the drug, it can be gradually increased.
In case of development of allergic reactions, the patient should stop taking and urgently consult a doctor for advice.
With prolonged use of Imet, it is recommended to carry out regular monitoring of the hemogram and kidney function.
With the development of gastrointestinal bleeding, the signs of which are severe pain in the epigastric region, vomiting of the color of coffee grounds, black stools, it is necessary to stop taking the drug and consult a doctor.
In case of an exacerbation of an infectious pathology or the development of a new infection while using ibuprofen, the patient should contact the attending physician to prescribe antibiotic therapy.
During the period of using Imet, patients are advised to refrain from performing potentially dangerous types of work, including driving vehicles and mechanisms.
Drug interactions
With the simultaneous administration of Imet reduces the antihypertensive effect of amlodipine, captopril, angiotensin-converting enzyme (ACE) inhibitors and beta-blockers; pharmacological effect of furosemide, hypothiazide, hydrochlorothiazide and other diuretics.
The drug enhances the effect of anticoagulants, increasing the risk of gastrointestinal bleeding.
Ibuprofen in combination with lithium preparations, phenytoin, digoxin increases the level of their concentration in blood plasma.
When taken simultaneously, the drug displaces indirect anticoagulants, sulfonylurea derivatives, oral hypoglycemic agents and hydantoin derivatives from the bonds with blood plasma proteins; increases the toxic effect of methotrexate and baclofen.
With the simultaneous use of Imet:
- Cholestyramine - helps to reduce the absorption of ibuprofen in the gastrointestinal tract;
- Warfarin - promotes the development of microhematuria and hematomas, an increase in the period of bleeding;
- Acetylsalicylic acid - reduces the plasma concentration of ibuprofen;
- Magnesium hydroxide - increases the initial absorption of ibuprofen in the gastrointestinal tract;
- Glucocorticosteroids - increase the likelihood of side effects from the digestive system.
Analogs
Imet's analogs are: Dolgit, Diklo-F, Ibuprom, Ibuprofen, Nurofen, Rapten, Remisid.
Terms and conditions of storage
Store in a dark, dry place at temperatures from 15 to 30 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
