Antiflu kids
Antiflu kids: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Antiflu Kid's
ATX code: N02BE51
Active ingredient: ascorbic acid (Ascorbic acid) + paracetamol (Paracetamol) + chlorphenamine (Chlorphenamine)
Manufacturer: Contract Pharmacal Corporation (USA)
Description and photo updated: 2019-27-08
Prices in pharmacies: from 150 rubles.
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Antiflu kids is a drug for the symptomatic treatment of colds in children.
Release form and composition
It is produced in the form of a white free-flowing powder with a faint raspberry smell, intended for the preparation of a solution for oral administration (12 g each in foil sachets, in a cardboard box of 5 or 8 sachets and instructions for use of Antiflu kids).
1 sachet contains active substances:
- 160 mg paracetamol;
- 50 mg of ascorbic acid;
- 1 mg chlorpheniramine maleate.
In addition, the preparation contains auxiliary components: citric acid, raspberry flavor, colloidal silicon dioxide, tribasic sodium citrate, corn starch, tribasic calcium phosphate, titanium dioxide, dye.
After dissolving the powder in water, an opaque pink solution with a raspberry smell is formed.
Pharmacological properties
Pharmacodynamics
Antiflu kids is a combined drug used for the symptomatic treatment of acute respiratory and colds. Its effects are due to the properties of the incoming components:
- paracetamol is an antipyretic analgesic that has antipyretic, analgesic and weak anti-inflammatory effects;
- ascorbic acid (vitamin C) improves the tolerance of paracetamol and increases the body's resistance to infections;
- chlorphenamine maleate is a blocker of H1-histamine receptors, has antiallergic effect, eliminates rhinitis symptoms, itching in the nose and eyes, watery eyes.
Thanks to the effects of the active ingredients, Antiflu kids reduces fever, sore throat, muscle pain and headache, as well as rhinitis symptoms.
Pharmacokinetics
Data on the pharmacokinetic parameters of Antiflu kids are not provided.
Indications for use
Antiflu kids are recommended for use in children aged 2 to 12 years for symptomatic treatment of acute respiratory viral infections (ARVI), including influenza and colds, in order to relieve symptoms such as fever, headache and muscle pain, sore throat, aches in the body, chills, runny nose, watery eyes, nasal congestion, sneezing.
Contraindications
Absolute:
- severe impairment of hepatic / renal function;
- hypertrophy of the prostate;
- angle-closure glaucoma;
- fructose intolerance, sucrase (isomaltase) deficiency, glucose-galactose malabsorption;
- the period of pregnancy and lactation (breastfeeding);
- children under 2 years of age;
- hypersensitivity to components.
Relative (Antiflu kids for children must be taken with caution): arterial hypertension, diabetes mellitus, severe cardiovascular diseases, bronchial asthma, thyrotoxicosis, chronic obstructive pulmonary disease, pheochromocytoma, difficulty urinating with prostate adenoma, congenital hyperbilirubin-Jonesmona syndrome (syndrome, Gilbert, Rotor), blood diseases, progressive malignant diseases, hyperoxaluria, viral hepatitis, glucose-6-phosphate dehydrogenase deficiency.
Antiflu kids, instructions for use: method and dosage
Antiflu kids can be used with or without food.
Before use, the powder should be dissolved in 150 ml of warm water.
For children from 2 to 5 years old, 1 sachet of the drug is dissolved at one time. The daily dose for this age is no more than 3 sachets per day. For children from 6 to 12 years old, a single dose is 2 sachets.
If necessary, the medication can be taken every 4-6 hours.
The maximum duration of treatment is 5 days. The possibility of taking the medicine for a longer period is determined by the doctor individually.
Side effects
- digestive system: nausea / vomiting, stomach discomfort, diarrhea, abdominal pain;
- hematopoietic system: thrombocytopenia, anemia, hemolytic anemia, thrombocytopenic purpura, pancytopenia, leukopenia, agranulocytosis, methemoglobinemia;
- central nervous system: headache, dizziness, sleep disturbance or drowsiness, agitation, fatigue, decreased speed of psychomotor reactions;
- hepatobiliary system: impaired liver function (increased activity of hepatic transaminases), hepatitis, dose-dependent hepatic failure, liver necrosis; with prolonged unjustified use of Antiflu kids, the development of liver fibrosis / cirrhosis is possible;
- urinary system: urinary retention; long-term use of high doses has a nephrotoxic effect, manifested by kidney damage;
- respiratory organs: bronchospasm / exacerbation of bronchial asthma, including with increased sensitivity to acetylsalicylic acid, other non-steroidal anti-inflammatory drugs (NSAIDs);
- hypersensitivity reactions: urticaria, skin rash, pruritus, Lyell's syndrome (toxic epidermal necrolysis), Stevens-Johnson syndrome (polymorphic-bullous erythema), acute generalized exanthematous pustulosis, Quincke's edema (angioedema), anaphylactic shock.
- other: paresis of accommodation, mydriasis, increase in intraocular pressure.
Overdose
In case of overdose, you must immediately seek qualified medical help.
An overdose of Antiflu kids can be caused by exceeding the doses of any of the active ingredients that make up it:
- paracetamol: symptoms of overdose are decreased appetite, nausea / vomiting, diarrhea, abdominal pain / discomfort in the abdominal cavity, hyperhidrosis. After taking an increased dose, an acute overdose develops in 6-14 hours, chronic - in 2-4 days. In severe poisoning, it is possible to develop severe liver failure, up to hepatic encephalopathy, coma and death. Also, in conditions of acute / chronic overdose, hypokalemia and metabolic acidosis (lactic acidosis) may develop. Often on the 3-5th day of an overdose, fever, jaundice, hepatic odor from the mouth, hypoglycemia, hemorrhagic diathesis, and hepatic failure appear. Development of acute renal failure with acute tubular necrosis, determined by severe pain in the lumbar region, hematuria, proteinuria,can develop even without severe liver dysfunction. For the treatment of the condition in the first 6 hours, gastric lavage, intake of sorbents (activated carbon) is recommended; after 8-9 hours - the introduction of donors of SH-groups and precursors of the synthesis of glutathione (methionine) and after 12 hours - N-acetylcysteine;
- chlorpheniramine: overdose symptoms are agitation, dizziness, depression, sleep disturbances, convulsions, coma. Treatment is recommended symptomatic;
- ascorbic acid: in a high dose (more than 3 g), it can cause temporary osmotic diarrhea, disruption of the gastrointestinal tract (nausea, discomfort in the stomach). Treatment is recommended to be symptomatic, if necessary - forced diuresis.
special instructions
Antiflu kids contains natural sugar in the amount of 1 XE (bread unit) per 1 sachet.
In very rare cases, serious skin reactions have been reported. In case of reddening of the skin, rash, peeling or blistering, therapy should be interrupted and seek medical attention immediately.
Ascorbic acid and paracetamol can distort laboratory data such as the quantitative determination of plasma glucose and uric acid, bilirubin concentration, hepatic transaminase activity, lactate dehydrogenase.
If the fever lasts more than 3 days, and the pain syndrome lasts for more than 5 days, you should consult a doctor.
Influence on the ability to drive vehicles and complex mechanisms
Due to the fact that Antiflu kids causes drowsiness, for 4 hours after taking it, you should refrain from activities that require quick reaction and increased concentration of attention.
Application during pregnancy and lactation
It is not recommended to use Antiflu kids during pregnancy and breastfeeding.
Pediatric use
Antiflu kids can be used to treat children from 2 years of age.
With impaired renal function
It is contraindicated to use the drug in case of severe renal dysfunction.
For violations of liver function
It is contraindicated to use Antiflu kids for severe liver dysfunction.
Drug interactions
With simultaneous use with Antiflu kids, the following drug interaction reactions are possible:
- benzylpenicillin and tetracyclines: an increase in their plasma concentration;
- iron preparations: improving their absorption in the intestine (by the transition of ferric iron to bivalent), it is possible to increase the excretion of iron in the case of simultaneous use with deferoxamine;
- short-acting salicylates and sulfonamides: slowing down the excretion of acids by the kidneys, increasing the risk of crystalluria;
- drugs with an alkaline reaction (including alkaloids): accelerating their excretion;
- oral contraceptives: a decrease in their concentration in the blood;
- isoprenaline: a decrease in its chronotropic efficacy;
- antipsychotic drugs (neuroleptics - phenothiazine derivatives): a decrease in their therapeutic effect;
- amphetamine and tricyclic antidepressants: inhibition of their tubular reabsorption;
- uricosuric drugs: decreasing their effectiveness;
- anticoagulants: it is possible to increase / decrease their effectiveness; paracetamol (or its metabolites) interact with enzymes involved in the synthesis of vitamin-K-dependent blood coagulation factors, while the interaction of paracetamol with warfarin or coumarin derivatives can lead to an increase in INR (international normalized ratio) and an increased risk of bleeding; concomitant use of oral anticoagulants with paracetamol requires medical supervision;
- ethanol: an increase in its total clearance is possible; alcohol aggravates the sedative effect of chlorphenamine, helps to reduce the concentration of ascorbic acid, as well as the development of acute pancreatitis;
- antidepressants, antiparkinsonian and phenothiazine antipsychotic drugs: the likelihood of side effects may increase (dryness of the oral mucosa, urinary retention, constipation);
- glucocorticosteroids: increased risk of developing glaucoma;
- inducers of microsomal oxidation in the liver (barbiturates, phenylbutazone, phenytoin, ethanol, tricyclic antidepressants, rifampicin): I promote an increase in the production of hydroxylated active metabolites of paracetamol, thereby increasing the likelihood of developing severe hepatotoxic reactions even with a slight overdose;
- inhibitors of microsomal oxidation (cimetidine): help reduce the risk of hepatotoxic effects of paracetamol;
- Diflunisal: there is an increase in the plasma concentration of paracetamol by 50%, as a result, the hepatotoxic effect of the drug increases;
- barbiturates: reduce the effectiveness of paracetamol, increase the excretion of ascorbic acid in the urine;
- sleeping pills: Antiflu kids enhances their effect;
- chloramphenicol: an increase in toxic effects is possible due to an increase in its half-life from blood plasma;
- drugs that delay gastric emptying (propantheline): can slow down the absorption of paracetamol, which leads to a later onset of its action;
- medicines that accelerate gastric emptying (metoclopramide): may increase the absorption of paracetamol, thus accelerating the onset of its action;
- antagonists of tropisetron and granisetron, 5-hydroxytryptamine type 3: they can absolutely inhibit the analgesic effect of paracetamol through pharmacodynamic interaction;
- zidovudine: should not be taken together with paracetamol without a doctor's recommendation, as the tendency to neutropenia (a decrease in the number of leukocytes) may increase;
- other pain relievers: due to the possible cumulative side effects, continuous combination therapy of Antifluids with more than one drug of this effect should be avoided.
Antiflu kids are not recommended to be taken simultaneously with ethanol-containing products, sedatives and hypnotics.
Analogs
Antiflu kids analogs are:
- For active substances - Antigrippin and FluZiOZ-F;
- By the mechanism of action - Panadol, Ifimol, Ksumapar, Prohodol, Novalgin, AntiFlu, Calpol, Gewadal, Kaffetin, Fervex, Solpadein, Daleron, Migrenol, Colds, Grippostad, Coldrex, Dolaren, Femizol, TeraFlurim, Paracetamol, Paracetam No-spasma, Pentalgin, Rinzasip, AjiKOLD, Unispaz, Rankof, Flukoldin, Flutabs and others.
Terms and conditions of storage
Store in a dry place at a temperature of 15-30 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Antiflu kids
Reviews about Antiflu kids for children are mostly positive: the drug quickly brings down fever and significantly alleviates colds. Additional advantages include good solubility of the powder in water, pleasant taste of the drink. The disadvantages of Antiflu kids are the presence of dyes in the composition and a large amount of auxiliary substances, as well as a fairly high cost.
In negative messages, parents write about the weak effectiveness of Antiflu kids and its inability to reduce high body temperature. Of the side effects, drowsiness is most often mentioned.
Price for Antiflu kids in pharmacies
The price for Antiflu kids is about 203–259 rubles. per package containing 5 sachets.
Antiflu kids: prices in online pharmacies
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Drug name Price Pharmacy |
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AntiFlu Kids 160 mg + 1 mg + 50 mg powder for oral solution 12 g 5 pcs. RUB 150 Buy |
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Antiflu kids powder for prig solution for internal approx. 12g 5 Pcs. 230 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
