Passage - Instructions For The Use Of Tablets, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Passages

Passages: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Passagix

ATX code: A03FA03

Active ingredient: domperidone (domperidone)

Producer: "Pharmaceutical enterprise" Obolenskoye ", JSC (Russia)

Description and photo update: 2018-23-10

Prices in pharmacies: from 81 rubles.

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Passage - a central blocker of dopamine receptors; antiemetic agent.

Release form and composition

• chewable tablets: round, flat-cylindrical, white or white with a creamy shade, with a risk (4, 6 and 10 pcs. in blisters, in a cardboard box 1, 2, 3, 4 or 5 packages);
• coated tablets: round, biconvex, white or white with a creamy / yellowish tinge, two layers are visible in the cross section (10 pcs. in blisters, in a cardboard box 1, 2 or 3 packages).

Active ingredient: domperidone, in 1 chewable and 1 coated tablet - 10 mg each.

Auxiliary components:

• chewable tablets: magnesium stearate, lactitol, menthol, xylitol, aspartame;
• coated tablets: Tween-80, Kollidon 30, lactose, titanium dioxide, sodium dodecyl sulfate, colloidal silicon dioxide, potato starch, calcium stearate, Klucel hydroxypropyl cellulose.

Pharmacological properties

Pharmacodynamics

Domperidone is a substance that increases the duration of peristaltic contractions of the antrum of the stomach and duodenum 12, eliminates the development of nausea and vomiting, increases the tone of the lower esophageal sphincter, accelerates gastric emptying if this process slows down.

The drug stimulates the release of prolactin from the pituitary gland; weakly penetrates the blood-brain barrier, therefore, with its use, extrapyramidal side effects rarely occur, especially in adults.

The antiemetic effect of domperidone is presumably due to a combination of gastrokinetic (peripheral) action and antagonism to dopamine receptors in the chemoreceptor trigger zone.

The drug does not affect gastric secretion.

Pharmacokinetics

Domperidone is rapidly absorbed after oral administration. With a reduced acidity of gastric juice, its absorption decreases.

The drug is characterized by low bioavailability - about 15%, high binding to plasma proteins - 91–93%.

The maximum concentration in blood plasma reaches 1 hour after administration. It is widely distributed in various tissues of the body, with the exception of brain tissues - here the concentration of the substance is low. It undergoes intensive metabolism in the intestinal wall and liver.

It is excreted: about 66% - through the intestines (unchanged 10% of the dose), about 33% - by the kidneys (unchanged 1% of the dose).

The half-life is 7-9 hours. In patients with renal insufficiency, it increases.

Indications for use

• delayed gastric emptying, gastroesophageal reflux, esophagitis and other disorders manifested by a complex of dyspeptic symptoms: flatulence, belching, heartburn (including with the throwing of stomach contents into the oral cavity), feeling of bloating, feeling of fullness in the epigastrium, pain in upper abdomen;
• nausea and vomiting of infectious, organic and functional origin, arising from a violation of the diet, radiotherapy and drug therapy, as well as caused by dopamine agonists (such as bromocriptine, L-dopa) in the case of their use in Parkinson's disease.

Contraindications

• a prolactin-secreting pituitary tumor (prolactinoma);
• gastrointestinal bleeding, perforation, mechanical obstruction and other conditions in which stimulation of the motor function of the stomach can be dangerous;
• children under 5 years old;
• individual intolerance to the components of the Passage.

Carefully:

• pregnancy;
• lactation period;
• renal / hepatic impairment.

Instructions for the use of Passage: method and dosage

Passage tablets should be taken orally, preferably 15-30 minutes before meals, since food slows down the absorption of domperidone somewhat.

Adults, depending on the indications, are prescribed:

• chronic dyspepsia: 10 mg 3 times a day and, if necessary, at bedtime;
• acute and subacute conditions, especially accompanied by nausea and vomiting: 20 mg 3-4 times a day and before bedtime.

Children from 5 years old, depending on the indications, are prescribed:

• chronic dyspepsia: 2.5 mg / 10 kg 3 times a day and, if necessary, at bedtime;
• acute and subacute conditions, especially accompanied by nausea and vomiting: 5 mg / 10 kg of body weight 3-4 times a day and before bedtime.

In chronic dyspepsia, in case of insufficient effect, the dose of the drug may be increased by 2 times.

Patients with renal insufficiency in case of repeated administration of Passage should reduce the frequency of its administration to 1-2 times a day and, if necessary, the dose.

Side effects

Passage is generally well tolerated, side effects are rare. There are isolated cases of transient bowel spasms and allergic reactions such as rashes and hives.

With increased permeability of the blood-brain barrier and in children, extrapyramidal disorders are possible. They are reversible and go away on their own after the end of therapy.

Passage may increase plasma prolactin levels. In exceptional cases, hyperprolactinemia leads to the development of gynecomastia, galactorrhea, dysmenorrhea.

Overdose

Domperidone overdose can cause drowsiness, disorientation and extrapyramidal phenomena, especially in children.

When taking significantly higher than the recommended dose, you should take activated charcoal and monitor the patient's condition. When extrapyramidal reactions occur, antihistamines and anticholinergic drugs, as well as drugs used for parkinsonism, can be effective.

special instructions

In the case of the simultaneous appointment of antisecretory or antacid drugs, they should be taken after meals, while domperidone should be taken before meals.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Passage does not affect the ability to concentrate, does not disturb the speed of mental and motor reactions.

Application during pregnancy and lactation

In experimental studies on animals, domperidone at a daily dose of up to 160 mg / kg did not have a teratogenic effect. In addition, there is no evidence of an increased risk of malformations when using the drug in humans. Nevertheless, in the first trimester of pregnancy, Passage, like most drugs, is recommended to be used only if the expected therapeutic benefit outweighs the potential risks.

The concentration of domperidone in breast milk of a nursing woman is 4 times lower than in plasma. However, it is not known if this concentration can have a negative effect on infants. For this reason, it is recommended to refrain from breastfeeding while taking Passazhik, unless the intended benefits justify the potential risks.

Pediatric use

For the treatment of children under 5 years old, the use of Passage is contraindicated.

With impaired renal function

Only a small part of the drug is excreted unchanged by the kidneys, so dose adjustment is not needed. However, with repeated use of Passage tablets, it is recommended to reduce the frequency of administration to 1–2 times a day, depending on the severity of renal failure; in some cases, a dose reduction may also be required.

For violations of liver function

Domperidone is metabolized in the liver, therefore, patients with hepatic impairment should be careful during treatment. With prolonged therapy, regular monitoring is required.

Drug interactions

Anticholinergics, when used simultaneously, can neutralize the effect of domperidone. Antisecretory and antacid drugs reduce its bioavailability.

It is possible that domperidone may affect the absorption of drugs with a sustained release of the active substance or those coated with an enteric coating.

Passage does not affect the level of digoxin and paracetamol in the blood if they are used simultaneously.

Drugs that significantly inhibit the cytochrome CYP3A4 enzyme (HIV protease inhibitors, antibiotics from the macrolide group, antifungal agents from the azole group, antidepressant nefazodone) are believed to increase plasma domperidone levels.

Analogs

Passazhiks analogs are: Domet, Domperidone, Domperidon-Teva, Domridon, Domstal, Motijekt, Motilak, Motilium, Motilium Express, Motinorm, Motonium.

Terms and conditions of storage

Store for no more than 2 years in a dry place out of reach of children, at temperatures up to 25 ° C.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Passage

Reviews about Passage are predominantly positive: the drug quickly and effectively eliminates disorders of the digestive system such as heartburn, nausea, heaviness in the stomach and bloating, including in case of errors in nutrition.

Patients respond very well to chewable tablets: they have a pleasant mint taste, they are convenient to take anywhere, since there is no need to drink water, which is especially important in case of nausea, when even a sip of water can cause a gag reflex.

Price for Passages in pharmacies

The price of Passage in the form of chewable tablets and coated tablets is approximately the same and amounts to 100–130 rubles. per pack of 10 and 195-220 rubles. per pack of 30 pcs.

Passages: prices in online pharmacies

Drug name Price Pharmacy

Passage 10 mg chewable tablets 10 pcs. RUB 81 Buy

Passage tablets chewable. 10mg 10 pcs. 130 RUB Buy

Passage 10 mg chewable tablets 30 pcs. 209 RUB Buy

Passage tablets chewable. 10mg 30 pcs. 288 r Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!