Zorex
Zorex: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Zorex
ATX code: V03AB09
Active ingredient: dimercaptopropanesulfonate sodium + calcium pantothenate (sodium dimercaptopropanesulfonate + calcium pantothenate)
Manufacturer: JSC "Valenta Pharmaceuticals" (Russia)
Description and photo update: 2019-20-08
Prices in pharmacies: from 300 rubles.
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Zorex is an antidote, donor of sulfhydryl (thiol) groups with antioxidant and hepatoprotective effects.
Release form and composition
The dosage form of Zorex is hard gelatin capsules: sizes No. 0 and No. 00, have a white body and a pink lid, contain powder with a structure that is prone to clumping, white with a cream shade of color and granules, a specific weak odor is possible (in a blister strip: 10 pcs. in a cardboard box 1 package; 2 pcs., in a cardboard box 1 package; 5 pcs., in a cardboard box 2 packages).
Content of active ingredients in 1 capsule:
- Dimercaptopropanesulfonate sodium (unitiol): in No. 0 - 150 mg or in No. 00 - 250 mg;
- Calcium pantothenate: in No. 0 - 7 mg or in No. 00 - 10 mg.
Auxiliary components: microcrystalline cellulose, pregelatinized starch, povidone, magnesium hydrogen phosphate trihydrate, colloidal silicon dioxide, citric acid (citric acid monohydrate).
Composition of hard gelatin capsules: titanium dioxide (E171), gelatin, azorubin (E122).
Pharmacological properties
Pharmacodynamics
The drug is characterized by a detoxification effect, which manifests itself, among other things, in relation to arsenous substances, heavy metals and their compounds, products of ethyl alcohol metabolism. The antioxidant and hepatoprotective effects of Zorex, confirmed by clinical studies, are due to the presence of sodium dimercaptopropanesulfonate in its composition. Its active sulfhydryl groups interact with the metabolic products of alcohol (ethanol) and thiol poisons contained in tissues and blood. The result is the formation of complexes - non-toxic compounds that are excreted in the urine.
When taken orally, sodium dimercaptopropanesulfonate enters the portal bloodstream and along with it enters the liver, where it quickly and irreversibly binds to acetaldehyde. This process contributes to the subsequent elimination of ethanol from other tissues and organs.
Sodium dimercaptopropanesulfonate is also an activator of acetaldehyde dehydrogenase, accelerating the oxidation of ethyl alcohol and the detoxification of its products with toxic properties by the liver enzyme system. Calcium pantothenate, which is part of Zorex, enhances the detoxification effect of sodium dimercaptopropanesulfonate. Pantothenic acid stimulates regeneration processes, accelerates the formation of corticosteroids and is an important element of fat and carbohydrate metabolism.
Pharmacokinetics
After oral administration of the Zorex capsule, which contains 250 mg of sodium 2,3-dimercaptopropanesulfonate, the maximum concentration of the active component of the drug in the blood is reached after about 1.5 hours and ranges from 90 to 140 mg / l. On average, the drug is completely excreted from the body after 9–11 hours (range of variation 10.16 ± 0.39 hours). The residence time of sodium dimercaptopropanesulfonate in the gastrointestinal tract is 15–20 minutes. The half-life of the drug is 7.5 ± 0.46 hours. Calcium pantothenate is well absorbed in the intestines and is degraded with the release of pantothenic acid. Approximately 60% of the drug is excreted through the kidneys, and it is also partially excreted through the intestines.
Indications for use
- Intoxication with cardiac glycosides, acute and chronic forms of poisoning with inorganic and organic compounds of mercury, arsenic, gold, cadmium, chromium, cobalt, zinc, copper, nickel, antimony, bismuth;
- Alcohol withdrawal syndrome, for the treatment and prevention of a hangover;
- Chronic alcoholism (as part of complex therapy).
Contraindications
- Severe liver disease in the stage of decompensation;
- Severe kidney disease in the stage of decompensation;
- Age under 18;
- The period of pregnancy and breastfeeding;
- Hypersensitivity to drug components.
According to the instructions, Zorex is recommended to be used with caution in patients with low blood pressure.
Instructions for the use of Zorex: method and dosage
Zorex capsules are taken orally, without chewing, 30 minutes before meals, with water.
Recommended dosage:
- Poisoning with salts of heavy metals and arsenic compounds: from 2 capsules No. 0 to 4 capsules No. 00 per day, evenly distributed over 2-3 doses. The therapy period is 7-10 days;
- Hangover prevention: 1 capsule No. 00 before going to bed after drinking alcohol;
- Treatment of alcohol withdrawal syndrome: 1 capsule No. 00 1-2 times a day, if necessary, the frequency of administration can be increased up to 3 times a day. The period of treatment is from 3 to 7 days, until the state of complete detoxification of the body;
- Chronic alcoholism: 1 capsule No. 0 1-2 times a day. The course of therapy is 10 days.
Side effects
The use of Zorex can cause side effects:
- Allergic reactions: rarely - urticaria, skin itching and rash, swelling of mucous membranes, rash on the mucous surfaces of the body, stomatitis, genital itching; very rarely - Steven-Johnson syndrome or angioedema (with typical signs in the form of a sudden increase in body temperature, malaise, bullous or maculo-vesicular rashes on the mucous membranes of the mouth and genitals, on the skin and in the anus);
- Others: when taking high doses - dizziness, nausea, pallor of the skin, tachycardia.
If symptoms of undesirable effects appear, you must stop taking the capsules and consult a doctor.
Overdose
Overdose symptoms can be observed when the therapeutic dose is exceeded by more than 10 times. These include shortness of breath, short-term convulsions, stunnedness, lethargy, lethargy, hyperkinesis.
As therapeutic measures, gastric lavage followed by laxatives and activated charcoal, administration of dextrose, and oxygen therapy in acute cases are recommended. Symptomatic therapy is also prescribed.
special instructions
The likelihood of developing allergic reactions is higher in patients with bronchial asthma or a history of allergies.
Influence on the ability to drive vehicles and complex mechanisms
Zorex does not affect the patient's ability to drive vehicles and mechanisms and to perform other potentially hazardous types of work that require the speed of psychomotor reactions and increased concentration of attention.
Drug interactions
Zorex is not compatible for simultaneous use with drugs, including heavy metal salts, with alkalis (quickly decomposes).
Analogs
Zorex's analogues are Methionine, Anexat, Naloxon, Acizol, Sodium thiosulfate, Potassium permanganate, etc.
Terms and conditions of storage
Store in a dry, dark place at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Zorex
There are a variety of reviews about Zorex. Most of them confirm the high efficiency of the drug, however, when using it, side effects may appear, especially if the patient's body is prone to allergic reactions.
The price of Zorex in pharmacies
The approximate price for Zorex with a dosage of 250 mg + 10 mg is from 317 to 610 rubles (for a package containing 2 capsules) or from 690 to 1257 rubles (for a package containing 10 capsules). The drug in a dosage of 150 mg + 7 mg is currently not on sale.
Zorex: prices in online pharmacies
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Drug name Price Pharmacy |
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Zorex 250 mg + 10 mg capsules 2 pcs. RUB 300 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
