Artroker
Artroker: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Artrocare
ATX code: M01AX21
Active ingredient: diacerein (diacerein)
Manufacturer: Micro Labs Limited (India)
Description and photo update: 2019-16-08
Prices in pharmacies: from 716 rubles.
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Artroker is a non-steroidal anti-inflammatory drug (NSAID), an inhibitor of the activity and synthesis of IL-1 (interleukin-1); inhibits the development of inflammation, degradation and subsequent destruction of cartilage tissue in osteoarthritis.
Release form and composition
Dosage form of the drug - capsules: No. 2, gelatinous hard, with the inscription Micro / Micro, body - gray, lid - blue, filled with yellow granular powder (10 pcs. In aluminum strips or aluminum / aluminum blisters, in a cardboard box 1, 3 or 10 strips or blisters).
1 capsule contains:
- active substance: diacerein - 50 mg;
- auxiliary components: povidone, lactose monohydrate, croscarmellose sodium, magnesium stearate, sodium lauryl sulfate, colloidal silicon dioxide;
- capsule body: gelatin, titanium dioxide, brilliant blue dye, floxin B dye, propyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium lauryl sulfate, water;
- capsule cap: gelatin, titanium dioxide, brilliant blue dye, floxin B dye, quinoline yellow dye, propyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium lauryl sulfate, water.
Pharmacological properties
Pharmacodynamics
Diacerein is an inhibitor of the synthesis and activity of interleukin-1 (IL-1), which plays an important role in the development of inflammation, degradation and subsequent destruction of cartilage in osteoarthritis. Diacerein also helps to slow down the formation of metalloproteinases (collagenases) involved in the processes of damage to cartilage tissue. In the case of prolonged use, the active ingredient stimulates the synthesis of proteoglycans without affecting the synthesis of prostaglandins.
Pharmacokinetics
After oral administration, diacerein is rapidly absorbed from the gastrointestinal tract, completely deacetylated to rhein. In the case of simultaneous administration of the drug with food, bioavailability increases by 25%. The time to reach the maximum concentration of rhein (C max) in blood plasma is 2.4 hours. The half-life is 4.25 hours. The connection between rhein and albumin is about 100%. In the case of a single dose of the drug at a dose of 50 mg, C max is 3.15 mg / l, and with repeated use, C max increases due to the accumulation of the drug. About 20% of rhein is excreted unchanged by the kidneys, 60% in the form of glucuronide, another 20% in the form of sulfate. Rein is able to penetrate the blood-brain and placental barriers.
Indications for use
According to the instructions, Artroker is indicated for use in primary and secondary osteoarthritis.
Contraindications
Absolute:
- severe renal / liver dysfunction;
- inflammatory bowel disease, intestinal obstruction;
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
- the period of pregnancy and breastfeeding (lactation);
- children and adolescents up to 18 years old;
- hypersensitivity to anthraquinone glycosides (laxatives of the anthraquinone group - buckthorn bark, senna leaf, etc.);
- increased individual intolerance to the active and / or auxiliary components of the drug.
In special cases, with caution and under medical supervision, NSAIDs are prescribed to patients when diagnosing irritation of the lower intestinal tract.
Instructions for the use of Artroker: method and dosage
Artroker capsules are taken orally after a meal, without chewing (swallowing whole) and drinking water.
Recommended dosage regimen: 1 pc. 2 times a day (after breakfast and after dinner). A significant therapeutic effect is observed after 2-4 weeks from the start of taking the drug.
Artroker should be taken continuously for a long time or in long, at least 4 months, courses. The duration of the break between courses of therapy is determined by the doctor.
Side effects
At the beginning of treatment, negative side effects from the digestive system are possible, such as nausea, vomiting, diarrhea, and abdominal pain. In this case, it is necessary to reduce the dose to 1 capsule per day.
Increased individual sensitivity to the components of the drug can be manifested by hypersensitivity reactions of varying degrees of intensity, rash, itching.
During treatment, depending on the change in pH, an intense coloration of urine from yellow to brown is possible, which does not affect the therapeutic effect and does not require a dose reduction or discontinuation of the drug.
Overdose symptoms can be general weakness, diarrhea. In this case, or in case of accidental intake of the drug by children, you need to consult a doctor. Treatment is symptomatic.
Overdose
In cases of overdose, diarrhea and weakness may develop. In case of overdose or accidental use of Artroker by children, consult a doctor. Therapy is symptomatic.
special instructions
The duration of therapy depends on the achieved result and can be quite long. Before the onset of the development of the therapeutic effect, Artroker capsules can be taken in combination with other NSAIDs and non-narcotic analgesics.
Periodically, blood counts, the activity of liver enzymes, and the composition of urine should be monitored. Deterioration of renal function is the basis for reducing the dose of the drug or discontinuing it, at the discretion of the attending physician.
Application during pregnancy and lactation
It is forbidden to use Artroker during pregnancy and lactation.
Pediatric use
It is forbidden to use Artroker to treat patients under 18 years of age.
With impaired renal function
It is forbidden to use Artroker in the treatment of patients with severe renal failure.
For violations of liver function
It is forbidden to use Artroker in the treatment of patients with severe hepatic impairment.
Drug interactions
- drugs that affect the consistency of intestinal contents (for example, large amounts of fiber) - not recommended to be taken together with Artroker;
- antacids - reduce the absorption of diacerein;
- antibiotics or chemotherapy drugs (due to the effect on the intestinal microflora) - can increase the frequency of adverse events from the gastrointestinal tract.
Analogs
Artroker's analogs are: Arthrodarin, Diartrin, Diacerein, Diaflex Rompharm, Diacerein-Mac.
Terms and conditions of storage
Store in a dry, dark place at a temperature not exceeding 30 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Artroker
Reviews about Artroker are mainly positive: users note the effectiveness of the drug for pain in the spine, joints, osteoarthritis, etc. Negative reviews contain information about the slow action of the drug and side reactions in the form of diarrhea.
Price for Artroker in pharmacies
The approximate price for Artroker is: 30 capsules 50 mg - 1000 rubles, 100 capsules 50 mg - 2750 rubles.
Artroker: prices in online pharmacies
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Drug name Price Pharmacy |
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Artroker 50 mg capsules 30 pcs. 716 RUB Buy |
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Artroker capsules 50mg 30 pcs. 986 r Buy |
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Artroker 50 mg capsule 100 pcs. 2499 RUB Buy |
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Artroker capsules 50mg 100 pcs. 2873 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
