Artra MSM forte
Artra MSM forte: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: ARTRA MSM Forte
ATX code: M09AX
Active ingredient: Glucosamine + Chondroitin sulfate (Glucosamine + Chondroitin sulfate)
Manufacturer: Unipharm, Inc. (USA)
Description and photo updated: 20.11.2018
Prices in pharmacies: from 1749 rubles.
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Artra MSM forte is a combined preparation with anti-inflammatory action that stimulates the process of cartilage tissue regeneration.
Release form and composition
The dosage form of Arthra MSM forte is film-coated tablets: from dark orange to light yellow-orange, biconvex oval; the presence of a specific odor is permissible (in a cardboard box 1 polyethylene bottle of 30, 60 or 100 pcs. or 2-4, 6, 9 or 10 blisters of 10 or 15 pcs. in each).
Active ingredients in 1 tablet:
- sodium hyaluronate (in terms of hyaluronic acid) - 10 mg;
- glucosamine hydrochloride - 500 mg;
- sodium chondroitin sulfate - 400 mg;
- MSM (methylsulfonylmethane) - 300 mg.
Auxiliary components:
- core: colloidal silicon dioxide - 4 mg; microcrystalline cellulose - 199.4 mg; croscarmellose sodium - 50 mg; calcium hydrogen phosphate dihydrate - 119.6 mg; stearic acid - 48 mg; magnesium stearate - 10 mg;
- shell: Opadry II orange (dye sunny sunset yellow aluminum varnish - 0.92 mg; medium chain triglycerides - 0.6 mg; hypromellose - 17.56 mg; maltodextrin - 4.68 mg; polydextrose - 7.92 mg; dye titanium dioxide - 0.44 mg; talc - 7.88 mg) - 40 mg.
Pharmacological properties
Pharmacodynamics
Artra MSM forte has analgesic and anti-inflammatory effects. The components of the drug have the ability to inhibit the progression of osteoarthritis. Other effects include suppression of destruction and stimulation of regeneration of cartilage tissue, improvement of blood flow in the subchondral bone, and a decrease in the need for non-steroidal anti-inflammatory drugs.
The main properties of the components of Arthra MSM forte:
- sodium chondroitin sulfate - takes part in the synthesis of connective tissue and is an additional substrate for the formation of a healthy cartilage matrix. Stimulates the synthesis of proteoglycans and collagen type II, the formation of hyaluronan, and also maintains the viscosity of the synovial fluid, protects hyaluronan from the damaging effects of free radicals and enzymatic breakdown (by suppressing the activity of hyaluronidase);
- glucosamine hydrochloride - takes part in the synthesis of connective tissue; with the introduction of exogenous glucosamine, the production of cartilage matrix is enhanced and nonspecific protection against chemical damage to the cartilage is provided;
- MSM is a sulfur-containing organic compound (natural sulfur content - 34%). It has analgesic and anti-inflammatory effects. It is one of the key metabolites of dimethyl sulfoxide. It is part of many endogenous proteins (including connective tissue proteins - elastin, collagen, keratin), hormones and other metabolically active compounds;
- hyaluronic acid - is a polysaccharide of the group of acidic glycosaminoglycans, is one of the important components of the synovial fluid and determines its viscoelastic properties. The substance forms a covering layer on the entire inner surface, which helps to protect the articular cartilage and synovial membrane from mechanical damage, as well as from inflammation factors and free radicals.
Pharmacokinetics
When taken orally, the bioavailability of glucosamine is 25% (first pass effect through the liver).
Plasma concentration of chondroitin sulfate with a single oral dose of 800 mg (or 2 times a day for 400 mg) increases sharply for 24 hours. The absolute bioavailability is 12%. As high molecular weight and low molecular weight derivatives, approximately 10 and 20% of the dose taken, respectively, is absorbed.
In experimental models with oral administration, a certain bioavailability of hyaluronic acid was noted.
Chondroitin sulfate is distributed in tissues. Its highest concentrations are found in the articular cartilage, kidneys and liver. Approximately 30% of the dose taken persists for a long time in muscle and bone tissue.
Glucosamine is excreted mainly unchanged by the kidneys; partly through the intestines.
Chondroitin sulfate is metabolized by desulfurization. It is excreted in the urine. T 1/2 (half-life) - more than 5 hours.
Indications for use
- osteocondritis of the spine;
- osteoarthritis of the peripheral joints.
Contraindications
Absolute:
- pregnancy and lactation;
- age up to 15 years;
- individual intolerance to the components of the drug.
Relative (Artra MSM forte is prescribed under medical supervision):
- diabetes;
- blood clotting disorders;
- intolerance to seafood (shellfish, shrimp);
- bronchial asthma.
Instructions for the use of Artra MSM forte: method and dosage
Artra MSM forte tablets are taken orally.
The recommended single dose is 1 tablet. For 21 days, the drug is taken 2 times a day, then the frequency of administration is reduced to 1 time per day.
The duration of the course is at least 3 months.
Side effects
Possible side reactions: disturbances from the digestive system (in the form of epigastric pain, flatulence, diarrhea, constipation, nausea, vomiting), allergic reactions.
Overdose
There are no reports of overdose cases.
Probable main symptoms: nausea, vomiting, diarrhea, hemorrhagic rash.
Therapy: symptomatic (gastric lavage).
special instructions
In the presence of chronic diseases, a medical consultation is required before starting the course.
Application during pregnancy and lactation
According to the instructions, Artra MSM forte is not prescribed during pregnancy / lactation.
Pediatric use
For patients under 15 years of age, Artra MSM forte is not prescribed (safety profile has not been studied).
Drug interactions
Artra MSM forte is compatible with non-steroidal anti-inflammatory drugs and glucocorticosteroids.
Possible interactions:
- semi-synthetic penicillins: a decrease in their effect;
- tetracyclines: increasing their absorption;
- indirect anticoagulants, antiplatelet agents, fibrinolytics: enhancing their action.
Analogs
The analogues of Artra MSM forte are Teraflex M, Piaskledin 300, Adgelon, Alflutop, ARTPA, Biartrin, Wantong, Hondroflex, Artiplas, Rumalaya, Rumalon, KONDRONova.
Terms and conditions of storage
Store in a place protected from moisture at a temperature of 10-30 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Arthra MSM Fort
According to reviews, Artra MSM forte is an effective drug used for the regeneration of cartilage tissue. In rare cases, the development of adverse reactions, mainly from the digestive system, is reported.
Price for Artru MSM forte in pharmacies
The approximate price for Artru MSM Forte (60 tablets per pack) is 1,686-2,110 rubles.
Artra MSM forte: prices in online pharmacies
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Drug name Price Pharmacy |
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Artra MSM forte film-coated tablets 60 pcs. 1749 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
