Zopiclone
Zopiclone: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Zopiclone
ATX code: N05CF01
Active ingredient: zopiclone (zopiclone)
Manufacturer: Calyx Chemicals & Pharmaceuticals Pvt. (India)
Description and photo updated: 2019-27-08
Zopiclone is a sedative used to treat sleep disorders.
Release form and composition
The product is produced in the form of tablets: white with a creamy shade or white (10 pcs. In blisters, 2 packs in a cardboard box and instructions for the use of Zopiclone).
The composition of 1 tablet includes:
- Active ingredient: zopiclone - 7.5 mg;
- Auxiliary components: potato starch, 80 tablets, microcrystalline cellulose, talc, medical low molecular weight polyvinylpyrrolidone, aerosil, magnesium stearate.
Pharmacological properties
Pharmacodynamics
Zopiclone is a hypnotic from the group of cyclopirrolone derivatives, a non-benzodiazepine agonist of benzodiazepine receptors. It also has a sedative, anxiolytic, central muscle-relaxing, anticonvulsant and amnestic effect.
Zopiclone, like benzodiazepine derivatives, enhances GABA-ergic processes in the brain (when interacting with benzodiazepine receptors). This leads to an increase in the sensitivity of the GABA receptors to the mediator. However, it is believed that the substance interacts with other sites of the benzodiazepine receptor than benzodiazepines.
Features of the effect of zopiclone on sleep: a decrease in the time to fall asleep, a decrease in the number of nighttime awakenings, an increase in the total duration of sleep. It practically does not affect the structure of sleep, the amount of REM sleep does not significantly reduce. The consequences of using the drug upon awakening are absent or insignificant. Repeated doses of the drug are not accompanied by cumulation.
Pharmacokinetics
Zopiclone is rapidly and completely absorbed from the gastrointestinal tract. C max (maximum concentration of the substance) is reached in 1-3 hours. Easily penetrates the histohematological barriers, including the blood-brain, and spreads through organs and tissues, including the brain. The half-life is in the range of 5.5 to 6 hours; does not cumulate.
Indications for use
- Primary sleep disorders: difficult falling asleep, night and early awakening, transient situational and chronic insomnia;
- Secondary sleep disorders associated with mental disorders in cases where they significantly worsen the patient's condition.
Contraindications
- Decompensated respiratory failure;
- Age up to 15 years;
- Hypersensitivity to drug components.
Sleeping pills are not recommended for nursing and pregnant women.
In severe hepatic impairment, the drug should be used with extreme caution.
Zopiclone, instructions for use: method and dosage
Zopiclone tablets are taken orally, in 1 dose, shortly before bedtime.
The recommended adult daily dose is 7.5 mg (1 tablet). Against the background of severe or persistent insomnia, it can be doubled.
Elderly patients are recommended to start therapy with a minimum dose of 3.75 mg (0.5 tablets), with insufficient effectiveness and in the absence of side effects, it may increase.
Patients with functional impairment of the kidneys do not need to adjust the dosage regimen. In case of severe hepatic insufficiency, the drug should be taken in a daily dose of 3.75 mg.
Side effects
When the drug is used in the recommended doses, therapy is generally well tolerated, and postsomnic disturbances develop infrequently.
During treatment, you may experience:
- Very common: a mild sensation of a metallic or bitter taste in the mouth;
- Rarely: gastrointestinal disorders (in the form of nausea, vomiting), mental disorders (in the form of irritability, confusion, depression of mood);
- Very rare: allergic reactions (in the form of urticaria, rash).
On awakening, drowsiness may develop, and occasionally dizziness and impaired coordination of movements.
Overdose
The main symptoms: depression of the central nervous system, manifested in varying degrees of severity (in the form of drowsiness, loss of consciousness and other disorders).
Therapy: gastric lavage, intake of activated carbon; symptomatic treatment (determined by the degree of poisoning). In stationary conditions, flumazenil (benzodiazepine receptor antagonist) is used. Hemodialysis is ineffective.
special instructions
During therapy, you should avoid taking alcohol and depriving psychotropic drugs.
Abrupt cessation of treatment does not cause withdrawal.
When using Zopiclone against the background of myasthenia gravis, due to a possible increase in muscle weakness, strict neurological control should be established for the condition of patients.
The duration of the course should not exceed 4 weeks.
Influence on the ability to drive vehicles and complex mechanisms
Due to the likelihood of dizziness and impaired coordination of movement the next day after taking Zopiclone, drive a car and perform potentially dangerous work with caution.
Application during pregnancy and lactation
Zopiclone tablets are not prescribed during pregnancy / lactation.
Pediatric use
For patients under 15 years of age, the drug is not prescribed.
For violations of liver function
Zopiclone with severe hepatic impairment should be used under medical supervision with extreme caution.
Drug interactions
With the simultaneous use of certain drugs, the following effects may occur:
- Muscle relaxants and deprimatory psychotropic drugs: enhancing their action;
- Trimipramine: a decrease in its concentration (this should be taken into account when prescribing drugs together, as well as with the simultaneous use of other tricyclic antidepressants).
Analogs
Zopiclone analogs are: Imovan, Relaxon, Zopiclone 7,5-SL, Zolinox, Somnol, Piklodorm, Thorson.
Terms and conditions of storage
Store in a dark place, out of reach of children, at room temperature.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Zopiclone
According to reviews, Zopiclone is fast acting and well tolerated. Of the shortcomings, they most often indicate the development of addiction.
The price of Zopiclone in pharmacies
The price of Zopiclone is unknown, as the drug is not available in pharmacies.
The approximate cost of analogues: Somnol (20 tablets) - from 172 rubles, Imovan (20 tablets) - from 260 rubles, Relaxon (20 tablets) - from 141 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
