Trimetazidin-Teva - Instructions For Use, Price, Reviews, Analogs Of Tablets

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Trimetazidin-Teva - Instructions For Use, Price, Reviews, Analogs Of Tablets
Trimetazidin-Teva - Instructions For Use, Price, Reviews, Analogs Of Tablets

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Trimetazidine-Teva

Trimetazidin-Teva: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. For violations of liver function
  13. 13. Drug interactions
  14. 14. Analogs
  15. 15. Terms and conditions of storage
  16. 16. Terms of dispensing from pharmacies
  17. 17. Reviews
  18. 18. Price in pharmacies

Latin name: Trimetazidine-Teva

ATX code: C01EB15

Active ingredient: trimetazidine (Trimetazidine)

Producer: Merkle, GmbH (Merckle, GmbH) (Germany)

Description and photo update: 2020-04-03

Prices in pharmacies: from 115 rubles.

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Film-coated tablets, Trimetazidine-Teva
Film-coated tablets, Trimetazidine-Teva

Trimetazidine-Teva is an antihypoxant drug that improves myocardial metabolism in conditions of ischemia.

Release form and composition

Dosage form - film-coated tablets: round, biconvex, red-brown shell (10 pieces in blisters, in a cardboard box with or without a protective sticker 3 or 6 blisters and instructions for use of Trimetazidine-Teva).

Composition for 1 tablet:

  • active substance: trimetazidine dihydrochloride - 20 mg;
  • auxiliary components: mannitol - 44.5 mg; MCC (microcrystalline cellulose) - 20 mg; copolyvidone - 4 mg; magnesium stearate - 1 mg; colloidal silicon dioxide - 0.5 mg;
  • film shell: polyethylene glycol (macrogol 6000) - 0.23 mg; hypromellose - 2.3 mg; dye iron oxide red (E172) - 0.1 mg; titanium dioxide (E171) - 0.49 mg.

Pharmacological properties

Pharmacodynamics

Trimetazidine-Teva helps to normalize energy metabolism in cells exposed to hypoxia or ischemia. It prevents a drop in the intracellular level of adenosine triphosphoric acid (ATP), maintains the normal function of membrane ion channels, ensures the transmembrane transport of sodium and potassium ions, as well as the maintenance of cellular homeostasis.

Trimetazidine inhibits fatty acid oxidation by selectively blocking long-chain 3-ketoacetyl-CoA thiolase. Thus, it enhances glucose oxidation and restores the conjugation between oxidative decarboxylation and glycolysis, which protects the heart muscle from ischemia. The antianginal action of trimetazidine is based on the substitution of glucose for fatty acids in the redox reaction.

Pharmacological properties of trimetazidine, confirmed in experimental studies conducted on animals:

  • support of energy metabolism of the myocardium and neurosensory organs during episodes of ischemia;
  • reducing the amount of intracellular acidosis and the degree of changes that occur during ischemia in the transmembrane ion flow;
  • decrease in the degree of infiltration and migration of polynuclear neutrophils in ischemic and reperfusion tissues of the heart muscle, decrease in the area of the damaged myocardium;
  • no effect on hemodynamics.

Pharmacokinetics

When taken orally, trimetazidine is absorbed quickly and almost completely by the intestinal mucosa.

The bioavailability of the substance is 90%. C max (maximum concentration) in plasma is noted at 55 ng / ml and is reached 2 hours after a single oral dose of 20 mg. V d (volume of distribution) - 4.8 l / kg.

Trimetazidine easily crosses histohematogenous barriers. It binds to plasma proteins at a level of 16%.

T 1/2 (half-life) varies from 4.5 to 5 hours. Basically, the substance is excreted by the kidneys, mainly unchanged (up to 60%).

Indications for use

Trimetazidine-Teva is recommended for long-term use for monotherapy or as part of a complex treatment of coronary heart disease in order to prevent angina attacks.

The drug is effective in the treatment of such cochleovestibular disorders of ischemic etiology as tinnitus, dizziness, and hearing impairment.

In addition, Trimetazidin-Teva is used for the treatment of chorioretinal vascular pathologies with an ischemic component.

Contraindications

  • renal failure in the terminal phase, with a glomerular filtration rate below 15 ml / min / 1.73 m 2;
  • severe violations of hepatic function;
  • pregnancy and breastfeeding;
  • children and adolescents under 18 years of age;
  • hypersensitivity to trimetazidine and / or auxiliary components of the drug.

Trimetazidin-Teva, instructions for use: method and dosage

Trimetazidine-Teva tablets are taken orally with food.

The recommended daily dosage for adult patients is 40-60 mg. The frequency of admission is 2-3 times a day.

The doctor sets the duration of the course of therapy individually, taking into account the clinical situation.

Side effects

  • digestive system: rarely - nausea, vomiting;
  • immune system: possible - itching, rash, other hypersensitivity reactions.

Overdose

Data on trimetazidine overdose have not been reported.

special instructions

Trimetazidine-Teva should not be taken to relieve angina attacks.

Against the background of trimetazidine therapy for coronary heart disease in patients, the daily need for nitrates significantly decreases.

Influence on the ability to drive vehicles and complex mechanisms

Trimetazidine-Teva does not affect the psychophysical and cognitive functions of patients, thereby not limiting their ability to drive vehicles and to perform other potentially hazardous types of work.

Application during pregnancy and lactation

Due to the lack of data from clinical studies on the safety and efficacy of using Trimetazidine-Teva during gestation, the drug is contraindicated for pregnant women.

There is no confirmed information on the release of trimetazidine during lactation. If necessary, the appointment of a drug during breastfeeding should be discontinued.

In the process of experimental studies, the teratogenic effect of trimetazidine has not been established.

Pediatric use

Due to the lack of confirmed information on the safe and effective use of the drug in children and adolescents under 18 years of age, Trimetazidine-Teva is not used in pediatric practice.

With impaired renal function

Trimetazidine-Teva tablets are contraindicated in patients with renal insufficiency with creatinine clearance less than 15 ml / min.

For violations of liver function

Trimetazidine-Teva is contraindicated in patients with severe liver dysfunction.

Drug interactions

Data on drug interactions with other substances / preparations are not provided by the manufacturer.

Analogs

Analogs of Trimetazidine-Teva are Antisten MV, Antisten, Angiosil retard, Vero-Trimetazidin, Deprenorm MV, Preductal OD, Precard, Rimecor MV, Triducard, Trimectal MV, Trimitard MV, etc.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Trimetazidine-Teva

In most reviews of Trimetazidine-Teva, patients indicate its high effectiveness. The drug helps to cope with sleep disorders, tinnitus, dizziness, weakness, fatigue. It improves memory, stabilizes the general condition of the body and well-being. The affordable cost of the drug is especially noted. There are no complaints about the development of side effects during therapy.

Price for Trimetazidine-Teva in pharmacies

The approximate price for Trimetazidine-Teva, 20 mg film-coated tablets, is 60 pcs per pack. - 259 rubles; per package 30 pcs. - 133 rubles.

Trimetazidine-Teva: prices in online pharmacies

Drug name

Price

Pharmacy

Trimetazidin-Teva 20 mg film-coated tablets 30 pcs.

115 RUB

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Trimetazidin-Teva tab. p.p. 20mg n30

129 RUB

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Trimetazidine-Teva 20 mg film-coated tablets 60 pcs.

214 r

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Trimetazidin-Teva tab. p.p. 20mg n60

237 r

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Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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