Tinidazole
Tinidazole: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Tinidazole
ATX code: P01AB02
Active ingredient: tinidazole (tinidazole)
Producer: Ozone, LLC (Russia), Biocom (Russia)
Description and photo update: 2019-21-08
Prices in pharmacies: from 34 rubles.
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Tinidazole is an antiprotozoal agent with antimicrobial action.
Release form and composition
Dosage form - film-coated tablets: cylindrical, convex on both sides, white or white with a cream shade; on the break, a core of white with a gray-cream shade of color is visible (4 and 10 pcs. in blisters, in a cardboard box 1, 2, 3, 4 or 5 packages; 4, 10, 16, 20, 30 and 50 pcs.. in polymeric containers, in a cardboard box 1 container).
Active ingredient: tinidazole, in 1 tablet - 500 mg.
Auxiliary components: potato starch, croscarmellose sodium, microcrystalline cellulose, povidone (polyvinylpyrrolidone), magnesium stearate.
Shell composition: titanium dioxide, macrogol, hypromellose, talc (magnesium hydrosilicate).
Pharmacological properties
Pharmacodynamics
Tinidazole is an antiprotozoal agent with antimicrobial action.
The drug is active against Lamblia spp., Trichomonas vaginalis and Entamoeba histolytica. It has a bactericidal effect against anaerobic microorganisms such as Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., Eubacterium spp., Bacteroides spp. (including Bacteroides fragilis and Bacteroides melaninogenicus), Peptococcus spp.
The mechanism of action of tinidazole is explained by its ability to inhibit synthesis and damage the structure of bacterial DNA.
Pharmacokinetics
After oral administration, tinidazole is almost completely absorbed. Its bioavailability is almost 100%. Only 12% binds to plasma proteins.
The maximum concentration in the blood after oral administration of 2 g of tinidazole is 40-51 μg / ml and is reached within 2 hours. After 24 hours, the plasma level of the drug is 11-19 μg / ml, after 72 hours - 1 μg / ml.
The volume of distribution of tinidazole is 50 liters. Penetrates the blood-brain barrier and the placenta. Within 72 hours after administration, it is excreted in breast milk.
It undergoes metabolism in the liver, resulting in the formation of pharmacologically active hydroxylated derivatives that enhance the action of tinidazole and inhibit the growth of anaerobic microorganisms.
The half-life is 12-14 hours. The drug is excreted in the bile - 50%, in the urine - 25% (unchanged) and 12% (in the form of metabolites). Undergoes reabsorption in the renal tubules.
Indications for use
- amoebiasis (including intestinal and hepatic forms);
- giardiasis;
- trichomoniasis (endometritis, colpitis, ovarian and tubo-ovarian abscesses);
- infections caused by anaerobic bacteria (with acute ulcerative gingivitis, lung abscess, pleural empyema, pneumonia; skin and soft tissue infections);
- mixed aerobic-anaerobic infections (in combination with antibiotics);
- eradication of Helicobacter pylori (in combination with antibiotics and preparations containing bismuth).
Tinidazole is also prescribed to prevent postoperative infectious complications caused by anaerobes.
Contraindications
- oppression of bone marrow hematopoiesis;
- organic diseases of the central nervous system;
- children under 12 years old;
- I trimester of pregnancy;
- lactation;
- hypersensitivity to drug components or other 5-nitroimidazole derivatives.
Instructions for the use of Tinidazole: method and dosage
Tinidazole tablets should be taken orally in order to avoid the development of side effects from the digestive system - during or after a meal.
Recommended dosage regimens:
- giardiasis, trichomoniasis: adults - 2000 mg once, children - 50-75 mg / kg once. If necessary, the drug is taken again in the same dose;
- infections in adults caused by anaerobes: the initial dose is 2000 mg once, from day 2 - 1000 mg per day. The course of therapy is 5–6 days;
- intestinal amebiasis: adults - 2000 mg per day for 2-3 days, children - 50-60 mg / kg for 3 days;
- hepatic amoebiasis: adults - 1500–2000 mg per day for 3–6 days, children - 50–60 mg / kg for 5 days.
To prevent the development of postoperative complications in adults, the drug is prescribed 12 hours before the forthcoming surgical intervention in a dose of 2000 mg.
Side effects
- allergic reactions: rash, pruritus, urticaria, angioedema;
- from the central nervous system: ataxia, dizziness, headache, peripheral neuropathy; rarely - convulsions;
- from the gastrointestinal tract: unpleasant taste and dry mouth, diarrhea, nausea, anorexia, vomiting;
- others: rarely - weakness, transient leukopenia.
Overdose
Overdose cases have not been described. There is no specific antidote for the drug. Symptomatic and supportive treatment is recommended. If a little time has passed since taking the drug, gastric lavage may be helpful. Tinidazole is easily removed from the body by dialysis.
special instructions
During treatment, you should not consume alcoholic beverages, since there is a risk of developing disulfiram-like reactions.
With long-term treatment (more than 6 days), it is necessary to control the peripheral blood picture.
In the case of genital trichomoniasis, both sexual partners should be treated.
Tinidazole makes the urine dark.
Influence on the ability to drive vehicles and complex mechanisms
During the period of therapy, it is recommended to be careful when driving and performing potentially dangerous types of work.
Application during pregnancy and lactation
According to the instructions, Tinidazole is contraindicated in the first trimester of pregnancy. In the II and III trimesters, the use of the drug is possible only in cases where the doctor decides that the expected benefit to the woman outweighs the potential risks to the fetus.
If a therapeutic course is required during lactation, it is recommended to stop breastfeeding, since tinidazole is determined in mother's milk within 72 hours after ingestion.
Pediatric use
Tinidazole tablets are not prescribed for children under 12 years of age, since its safety and efficacy in patients of this age category have not been established.
Drug interactions
Tinidazole is compatible with sulfonamides and antibiotics (rifampicin, erythromycin, aminoglycosides, cephalosporins). Its metabolism is accelerated with the simultaneous use of phenobarbital.
It is not recommended to use ethionamide during treatment.
The drug increases the effect of indirect anticoagulants. To reduce the risk of bleeding, the dose should be halved.
Tinidazole enhances the effect of ethanol.
Analogs
Tinidazole analogs are the following drugs: Tiniba, Tinidazol-Acri, Fazizhin.
Terms and conditions of storage
Keep out of the reach of children, protected from light and moisture, at temperatures up to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Tinidazole
According to most reviews, Tinidazole is an inexpensive but effective antimicrobial agent. In rare negative statements, there are complaints about the development of side effects, such as an unpleasant taste and dry mouth, nausea.
The price of tinidazole in pharmacies
Depending on the manufacturer and the pharmacy chain, the price of Tinidazole can vary approximately in the range from 25 to 90 rubles. per pack of 4 film-coated tablets, 500 mg each.
Tinidazole: prices in online pharmacies
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Drug name Price Pharmacy |
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Tinidazole 500 mg film-coated tablets 4 pcs. 34 rbl. Buy |
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Tinidazole 500 mg film-coated tablets 4 pcs. RUB 54 Buy |
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Tinidazole tablets p.o. 500mg 4 pcs. RUB 68 Buy |
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Tinidazole tab. by. 500 mg 4 Pcs. 73 rbl. Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
