Teturam - Instructions For The Use Of Tablets, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Teturam

Teturam: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. In case of impaired renal function
11. 11. For violations of liver function
12. 12. Drug interactions
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Terms of dispensing from pharmacies
16. 16. Reviews
17. 17. Price in pharmacies

Latin name: Teturam

ATX code: N07BB01

Active ingredient: Disulfiram (Disulfiram)

Manufacturer: Pharmstandard - Leksredstva, STI-MED-SORB, Tatkhimpharmpreparaty, AVVA-RUS (Russia)

Description and photo update: 2019-12-08

Prices in pharmacies: from 139 rubles.

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Teturam is an anti-alcohol drug.

Release form and composition

Dosage form - tablets: round flat-cylindrical shape, beveled, white with a yellow-green tint or white (10 pcs. In a blister strip, in a cardboard box 3 or 5 packs; 30 or 50 pcs. In a glass jar of dark color, in a cardboard bundle 1 can; in addition, 150 mg each: in a polymer can or a bottle of 30 or 50 pcs., in a cardboard bundle 1 can or bottle; in a contoured non-cell package of 10 pcs., in a cardboard bundle 3 or 5 packs; in a blister strip: 15 or 20 pcs., in a cardboard bundle 1, 2, 3 or 5 packages, or 10 pcs., in a cardboard bundle 1 or 2 packages).

1 tablet contains:

• active substance: disulfiram - 100 mg, 150 mg, 200 mg or 250 mg;
• auxiliary components: potato starch, aerosil (colloidal silicon dioxide), stearic acid.

Pharmacological properties

Pharmacodynamics

Disulfiram, the active ingredient of Teturam, is an inhibitor of the acetaldehyde dehydrogenase enzyme involved in the metabolism of ethanol, which increases the concentration of acetaldehyde, which is a metabolite of ethyl alcohol, 5-10 times. Acetaldehyde causes a number of unpleasant symptoms: nausea, vomiting, feelings of general malaise, flushing of the face, tachycardia, a sharp drop in blood pressure. This contributes to the development of a conditioned reflex reaction, which consists in the appearance of a feeling of aversion to the smell and taste of alcohol. The intensity of the reactions caused by Teturam is directly proportional to the dose taken.

The maximum therapeutic effect is observed 12 hours after taking the pills inside and can last for 10-14 days after stopping treatment. The degree of drug exposure is directly determined by the duration of the course of therapy.

Pharmacokinetics

After oral administration, the absorption of disulfiram is 70–90%. The substance is metabolized in the liver by reduction to diethyldithiocarbamate, which is excreted as glucuronide via the kidneys, or converted to diethylamine and carbon disulfide, the ratio of which varies from 4 to 53%. Carbon disulfide is released through the lungs. The minimum concentration of disulfiram in the blood is approximately 20 ng / ml.

Indications for use

The use of Teturam is indicated for the treatment of chronic alcoholism and the prevention of its relapse.

In addition, tablets are prescribed as a detoxification drug for chronic nickel poisoning.

Contraindications

• thyrotoxicosis;
• diseases of the cardiovascular system in the stage of decompensation (including atherosclerosis of the cerebral vessels, pronounced cardiosclerosis, coronary insufficiency, conditions before and after a heart attack, aortic aneurysm, stage II – III arterial hypertension);
• severe emphysema of the lungs;
• bronchial asthma;
• hemoptysis with pulmonary tuberculosis;
• erosive lesions of the gastrointestinal tract (GIT), bleeding from the gastrointestinal tract, exacerbation of gastric ulcer and duodenal ulcer;
• impaired renal function, liver failure;
• diabetes;
• glaucoma;
• neuropsychic pathologies, epilepsy;
• diseases of the central nervous system (CNS) of infectious origin;
• neuritis of the auditory and optic nerves;
• polyneuropathy;
• malignant neoplasms;
• the period of pregnancy and breastfeeding;
• individual intolerance to the components of the drug.

Care should be taken to use Teturam with a history of psychosis while taking disulfiram, with endarteritis, cardiovascular pathologies in the stage of compensation, residual symptoms of cerebrovascular accident, over the age of 60, during remission of gastric ulcer and duodenal ulcer.

Instructions for the use of Teturam: method and dosage

Teturam tablets are taken orally.

The prescription of the drug is made after a complete medical examination, the doctor must warn the patient about the possible consequences and complications.

Recommended dosage: on an individual basis from 150 to 500 mg 2 times a day. Teturam-alcohol test is carried out after 7-10 days of therapy, it consists in the patient taking 20-30 ml of vodka (40%) after 500 mg of the drug. In the case of a weak reaction, the amount of vodka is increased by 10–20 ml. The alcohol dose should not exceed 120 mg. Repeated tests with correction of alcohol and / or drug doses are carried out after 1-2 days in a hospital and 3-5 days later - on an outpatient basis. Maintenance therapy at a daily dose of 150-200 mg can be continued for 1-3 years.

Side effects

• disorders caused by the properties of the drug: confusion, headache, metal taste in the mouth, unpleasant odor (due to carbon sulfide) in patients with colostomy, memory loss, optic neuritis, asthenia, polyneuritis of the lower extremities, manifestation of allergic reactions on the skin; rarely - hepatitis (including in the absence of alcohol dependence in patients with nickel eczema);
• disorders caused by taking alcohol doses in excess of the equivalent of 50–80 ml of vodka during therapy: edema, severe disorders of the respiratory and cardiovascular systems, convulsions;
• disorders caused by the combination of Teturam with ethyl alcohol: possibly - respiratory failure, cerebral edema, cardiovascular collapse, angina pectoris, rhythm disturbances; sometimes - myocardial infarction, neurological disorders;
• disorders caused by complications during long-term therapy: exacerbation of polyneuritis; rarely - gastritis, hepatitis, psychosis (similar to alcoholic); possibly (with cardiovascular diseases) - cerebral thrombosis.

Overdose

Symptoms of an overdose of Teturam are neurological complications, blurred consciousness, coma, collapse.

There is no specific antidote to disulfiram. With a severe disulfiram-alcoholic reaction lasting about 1.5 hours, oxygen therapy is used. It is also recommended to inhale carbogen (a mixture of 95% oxygen and 5% carbon dioxide), intravenous administration of high doses of ascorbic acid (up to 1 g), antihistamines and ephedrine sulfate. It is necessary to constantly monitor the content of potassium in the blood serum, especially if the patient is taking digitalis drugs.

special instructions

Due to the risk of thrombosis of the cerebral vessels, immediate withdrawal of the drug is required when the patient develops facial numbness and paresthesias in the extremities.

With the development of severe disorders against the background of alcohol consumption in a dose exceeding the permissible threshold, the patient needs urgent detoxification therapy, including analeptics and symptomatic treatment.

When combining the drug with oral anticoagulants, the patient should be provided with frequent monitoring of the level of prothrombin concentration and appropriate correction of doses of anticoagulants. This will reduce the risk of bleeding.

Influence on the ability to drive vehicles and complex mechanisms

Taking Teturam tablets practically does not affect the ability to drive a car or perform potentially dangerous types of work.

Application during pregnancy and lactation

Pregnancy must be ruled out before taking Teturam. Reliable contraception should be used during treatment with disulfiram.

With impaired renal function

According to the instructions, Teturam is used with caution in patients with any degree of renal failure.

For violations of liver function

The drug is contraindicated in severe liver dysfunction. It is used with caution in liver dysfunctions.

Drug interactions

Due to the high risk of developing an intolerance reaction that causes vomiting, hot flushes, tachycardia, erythema, the simultaneous use of ethanol-containing drugs and the use of alcohol are contraindicated.

Undesirable combinations include a combination of a drug with the following agents:

• isoniazid - due to its ability to cause impaired coordination and behavior;
• ornidazole, tinidazole, metronidazole, secnidazole (nitro-5-imidazoles) - the risk of developing delirious disorders, confusion;
• phenytoin - reduces metabolism, rapidly and significantly increasing its level in blood plasma with symptoms of toxicity (in case of clinical need, treatment should be accompanied by laboratory control of the level of phenytoin in the blood).

With the simultaneous use of Teturam:

• oral anticoagulants, including warfarin, increase their effect and the risk of bleeding, therefore it is recommended to carry out more frequent checks of their concentration level and keep the dose of anticoagulants adjusted after discontinuation of the drug for 8 days;
• theophylline slows down your metabolism;
• benzodiazepines increase their sedative effect;
• tricyclic antidepressants can increase alcohol intolerance reactions.

Analogs

Analogs of Teturam are: Antabus, Esperal.

Terms and conditions of storage

Keep out of the reach of children.

Store in a place protected from moisture and light at temperatures up to 25 ° C.

Shelf life is 4 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Teturam

Reviews about Teturam are quite contradictory. The drug helped some patients, and some could not take it for a long time due to pronounced side effects. Negative experiences are usually reported by those who have combined the reception of Teturam with the use of alcoholic beverages: the consequences of such a combination can be quite dangerous. Therefore, it is recommended to use the drug only under the supervision of a specialist.

Doctors speak well of the drug, considering it effective when used in accordance with the instructions. It is prescribed when other common medications do not work. In no case should pills be secretly given to a person suffering from alcoholism: the combination of disulfiram with even a small amount of alcohol can lead to serious health problems.

Price for Teturam in pharmacies

The price for Teturam is approximately 173-240 rubles per pack of 50 tablets, depending on the place of sale. You can buy the drug in a package containing 30 tablets for 115-148 rubles.

Teturam: prices in online pharmacies

Drug name Price Pharmacy

Teturam 150 mg tablets 30 pcs. 139 RUB Buy

Teturam 150 mg tablets 50 pcs. 211 r Buy

Teturam 150 mg tablets 50 pcs. 214 r Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!