Spazmalin - Instructions For Use, Price, Reviews, Analogs, In Ampoules

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Spasmalin

Spazmalin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. In case of impaired liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Spasmalin

ATX code: N02BB52

Active ingredient: metamizole sodium (Metamizole sodium), pitofenon (Pitofenone), fenpiverinium bromide (Fenpiverinium bromide)

Manufacturer: Torrent Pharmaceuticals (India)

Description and photo update: 2018-22-10

Prices in pharmacies: from 111 rubles.

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Spazmalin is a spasmodic analgesic.

Release form and composition

Dosage forms of Spazmalin:

• tablets: yellowish-white or white, round, flat, on one side there is a dividing line (10 pcs. in blisters, in a cardboard box 2 or 10 blisters);
• solution for injection: clear liquid, from yellow to light yellow (5 ml each in dark glass ampoules, in blisters of 5 ampoules, in a cardboard box of 5 blisters).

1 tablet contains:

• active ingredients: metamizole sodium - 500 mg, pitofenone hydrochloride - 5 mg, fenpiverinium bromide - 0.1 mg;
• auxiliary components: colloidal silicon dioxide, sodium starch glycolate, magnesium stearate, microcrystalline cellulose, talc.

1 ml of solution contains:

• active ingredients: metamizole sodium - 500 mg, pitofenone hydrochloride - 2 mg, fenpiverinium bromide - 0.02 mg;
• auxiliary components: citric acid monohydrate, water for injection.

Pharmacological properties

Pharmacodynamics

The antispasmodic and analgesic properties of Spazmalin are provided by its combined composition.

Metamizole sodium - analgesic-antipyretic, pyrazolone derivative; has a pronounced non-narcotic analgesic, antipyretic and weak anti-inflammatory effect. Its therapeutic effect is based on the inhibition of prostaglandin synthesis.

Pitofenone is a myotropic antispasmodic, has a direct effect on the smooth muscles of the internal organs, causes its relaxation.

Fenpiverinium bromide is an m-anticholinergic antagonist and contributes to additional antispasmodic effects on smooth muscles.

Indications for use

• pain syndrome with spasms of smooth muscles of internal organs: biliary colic, renal colic, algodismenorrhea;
• symptomatic short-term therapy: arthralgia, neuralgia, sciatica, myalgia.
• condition after surgery and diagnostic interventions - as an aid to relieve pain.

In addition, the use of tablets is indicated for migraines and headaches.

Contraindications

• severe liver dysfunction;
• severe renal dysfunction;
• diseases of the hematopoietic system;
• granulocytopenia;
• deficiency of glucose-6-phosphate dehydrogenase;
• angle-closure glaucoma;
• tachyarrhythmia;
• benign prostatic hyperplasia;
• acute intermittent porphyria;
• collaptoid states;
• intestinal obstruction;
• megacolon;
• I trimester and the second half of the III trimester of pregnancy;
• breast-feeding;
• age up to 3 months or the patient's body weight is less than 5 kg;
• hypersensitivity to pyrazolone derivatives (including butadione), analgesics-antipyretics or nonsteroidal anti-inflammatory drugs (NSAIDs);
• individual intolerance to the components of the drug.

Care should be taken when prescribing Spazmalin to patients who are prone to arterial hypotension and bronchospasm, with impaired liver and (or) kidney function, under the age of 15 years.

Instructions for the use of Spazmalin: method and dosage

Pills

Spazmalin tablets are taken orally, after meals.

The dose of the drug is prescribed taking into account the age and clinical condition of the patient.

Recommended dosage for patients over 15 years old: 1–2 pcs. 2-3 times a day. The daily dose should not exceed 6 pcs. The duration of the course is no more than 5 days. An increase in the daily dose or prolongation of the course of therapy is possible only under the close supervision of a physician.

For children under 15 years of age, the drug can be prescribed only under strict indications and under medical supervision.

The recommended dosage for a single dose of Spazmalin:

• children aged 6–8 years: 1/2 pcs.;
• children aged 9–12 years: 3/4 pcs.;
• children aged 13-15: 1 pc.

Frequency rate of admission - 2-3 times a day.

Injection

Parenteral administration of the drug is indicated in emergency cases, including renal colic, biliary colic, and in conditions of the patient that do not allow taking tablets by mouth (including in case of impaired absorption from the gastrointestinal tract).

The solution is intended for intramuscular (i / m) and intravenous (i / v) administration.

Do not mix the Spazmalin solution in the same syringe with other drugs.

The dose is prescribed taking into account the patient's age.

The recommended dosage of Spazmalin for adults and adolescents over 15 years old:

• IV injection (slowly, in a horizontal position of the patient, monitoring the heart rate, blood pressure (BP), respiratory rate): 2 ml once;
• IM administration: 2–5 ml 2-3 times a day, but not more than 10 ml.

The duration of the course is no more than 5 days.

Due to the risk of a sharp decrease in blood pressure when prescribing a dose of 2 ml or more, special care is required.

The dose for children is determined in strict accordance with the age of the child.

Recommended dosage for a single intramuscular or intravenous injection of Spazmalin solution:

• Infants 3-11 months: 0.1 ml;
• children aged 1-4: 0.2 ml;
• children aged 5-7: 0.4 ml;
• children aged 8-11: 0.5 ml;
• children aged 12-14 years: 0.8 ml.

If it is necessary to re-administer Spazmalin, the procedure is carried out in the initial dose.

Side effects

• on the part of the cardiovascular system: possibly - tachycardia, lowering blood pressure, cyanosis;
• from the central nervous system: very rarely - accommodation paresis; isolated cases - headache; possibly dizziness;
• from the digestive system: isolated cases - dry mouth, burning sensation in the epigastric region;
• on the part of the urinary system: rarely (usually against the background of prolonged therapy or the use of high doses of the drug) - oliguria, proteinuria, renal dysfunction, anuria, urine staining red, interstitial nephritis; very rarely - urinary retention;
• on the part of the hematopoietic system: isolated cases (against the background of long-term use) - leukopenia, thrombocytopenia, agranulocytosis;
• allergic reactions: in patients with a predisposition to bronchospasm - provoking an attack; sometimes - a rash, itchy skin; very rarely - anaphylactic shock; isolated cases - Stevens-Johnson syndrome or malignant exudative erythema, Lyell's syndrome (toxic epidermal necrolysis);
• others: very rarely - decreased sweating.

Overdose

Symptoms: pain in the epigastric region, nausea, vomiting, drowsiness, lowering blood pressure, convulsions, functional impairment of the kidneys and liver, confusion.

Treatment: immediate gastric lavage, intake of activated charcoal. If necessary, the appointment of symptomatic therapy.

special instructions

The use of Spazmalin in therapeutic doses is usually well tolerated and does not cause the development of undesirable effects.

If the patient has thrombocytopenia or suspected agranulocytosis, immediate discontinuation of the drug is required.

If it is necessary to use the drug for more than 7 days, the patient should ensure careful monitoring of the functional state of the liver and the picture of peripheral blood.

During the course of therapy with Spazmalin, alcohol consumption is contraindicated.

Influence on the ability to drive vehicles and complex mechanisms

Due to the risk of developing side effects that affect the concentration of the patient's attention, during the period of using the drug, potentially hazardous activities, including driving vehicles and mechanisms, should be avoided.

Application during pregnancy and lactation

According to the instructions, Spazmalin is contraindicated for use in the first trimester and the second half of the third trimester of the pregnancy period.

Do not use Spazmalin solution in ampoules or tablets during breastfeeding. If it is absolutely necessary to prescribe the drug during lactation, breastfeeding should be temporarily stopped.

Pediatric use

The appointment of Spazmalin is contraindicated in children under the age of 3 months or with a body weight of up to 5 kg.

Since the appointment of the drug to children under the age of 15 is indicated only under strict indications, the doctor makes the decision on its use in each case individually.

The dose of the drug depends on the age of the child. For dosage, see the section "Method of application and dosage".

With impaired renal function

The drug should not be prescribed to patients with severe renal impairment.

In case of impaired renal function, the use of Spazmalin should be carried out under the supervision of the attending physician.

If liver function is impaired

You can not prescribe Spazmalin in case of severe liver dysfunction.

With mild and moderate liver dysfunction, the drug should be used with caution, under the close supervision of a physician.

Drug interactions

With simultaneous use with Spazmalin:

• non-opioid analgesics: can cause mutual reinforcement of action;
• inducers of microsomal liver enzymes, including phenylbutazone and barbiturates: cause a weakening of the pharmacological action of metamizole sodium;
• tricyclic antidepressants, allopurinol, oral contraceptives: contribute to the disruption of the metabolism of metamizole sodium in the liver, increasing its toxicity;
• cyclosporine: lowers the level of its concentration in blood plasma;
• butyrophenones, phenothiazines, quinidine, amantadine, blockers of histamine H1 receptors: can enhance the m-cholinolytic effect of the drug;
• tranquilizers, sedatives: enhance the analgesic effect of the drug;
• ethanol: may cause synergy.

Analogs

The analogues of Spazmalin are Trinalgin, Spazmalgon, Spazmoblok, Baralgetas, Renalgan, Bral, Spazmil-M, Spazgan, Spazmogard.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 30 ° C in a dark place.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Spazmalin

Reviews about Spazmalin are mostly positive. The authors of most of them resort to using the drug in cases of headache or menstrual pain. They are satisfied with the therapeutic effect, which occurs after 15 minutes, and do not feel the side effects of the drug. Some patients note a more pronounced antispasmodic effect of the drug, therefore, for a better analgesic effect, they take it in combination with analgesics.

Price for Spazmalin in pharmacies

The price of Spazmalin for a package containing 20 tablets is from 117 rubles, 100 tablets - from 419 rubles. The cost of Spazmalin solution in ampoules (25 pcs. In a package) is about 502 rubles.

Spazmalin: prices in online pharmacies

Drug name Price Pharmacy

Spazmalin tablets 20 pcs. RUB 111 Buy

Spazmalin solution for intravenous and intramuscular injection 5 ml 5 pcs. 113 RUB Buy

Spazmalin solution for in. 5ml 5 pcs 168 RUB Buy

Spazmalin solution for intravenous and intramuscular injection 5 ml 25 pcs. RUB 185 Buy

Spazmalin tablets 100 pcs. 367 r Buy

Spazmalin tablets 100 pcs. 410 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!