Spazoverin
Spazoverin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Spazoverin
ATX code: A03AD02
Active ingredient: drotaverine (Drotaverine)
Manufacturer: Shreya Life Science Pvt. Ltd. (Shreya Life Sciences, Pvt. Ltd.) (India)
Description and photo updated: 30.11.2018
Prices in pharmacies: from 142 rubles.
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Spazoverin is a myotropic antispasmodic agent.
Release form and composition
- tablets: biconvex, round, yellow (10 pcs. in blisters, in a cardboard box 1, 2, 3, 4, 5 or 10 blisters; 30, 50 or 100 pcs. in polystyrene containers with a polyethylene lid, in a cardboard box 1 container);
- solution for injection (1 or 2 ml in dark glass ampoules, in a cardboard box of 5 or 25 ampoules).
Each pack also contains instructions for the use of Spazoverin.
Composition of 1 tablet:
- active substance: drotaverine hydrochloride - 40 or 80 mg;
- auxiliary components: microcrystalline cellulose, starch, magnesium stearate, polyvinylpyrrolidone, talc.
Composition of 1 ml solution for injection:
- active substance: drotaverine hydrochloride - 20 mg;
- auxiliary components: disodium edetate, sodium metabisulfite, water for injection, ethyl alcohol.
Pharmacological properties
Pharmacodynamics
The active substance of Spazoverin - drotaverine hydrochloride, is a myotropic antispasmodic, which is close to papaverine in chemical structure and pharmacological properties, but has a more pronounced and lasting effect.
Drotaverine reduces the flow of calcium into smooth muscle cells (inhibits phosphodiesterase, leads to the accumulation of intracellular cyclic adenosine monophosphate). Reduces intestinal motility and smooth muscle tone of internal organs, dilates blood vessels. Does not penetrate the central nervous system and does not interact with the autonomic nervous system.
Since drotaverine has a direct effect on smooth muscles, it can be used as an antispasmodic in cases where the use of drugs from the group of m-anticholinergic antagonists is contraindicated (for example, in angle-closure glaucoma or prostate adenoma).
Pharmacokinetics
After oral administration, drotaverine is well absorbed, the half-absorption period is 12 minutes.
The antispasmodic is 100% bioavailable. The maximum concentration in the blood reaches after 2 hours. It is evenly distributed over the tissues, penetrates into smooth muscle cells. It binds to plasma proteins by 95–98%. Does not penetrate the blood-brain barrier.
The substance is excreted mainly with the kidneys, to a lesser extent - with bile.
Indications for use
- functional states and pain syndrome associated with smooth muscle spasm in diseases such as gastric ulcer and duodenal ulcer, spastic colitis, chronic cholecystitis, chronic gastroduodenitis, cholelithiasis, postcholecystectomy syndrome, cardio- and pylorospasm (for prevention and treatment);
- kidney stone disease;
- spasms of peripheral arterial and cerebral vessels;
- algodismenorrhea;
- labor (to relieve cervical spasm and weaken uterine contractions during childbirth);
- carrying out instrumental methods for diagnosing organs and systems.
Contraindications
Absolute:
- arterial hypotension;
- cardiogenic shock;
- atrioventricular block II – III degree;
- severe renal, hepatic, heart failure;
- hypersensitivity to any component of the Spazoverin solution or tablets.
Relative:
- severe atherosclerosis of the coronary arteries;
- glaucoma;
- prostate adenoma;
- the period of pregnancy and lactation.
Spazoverin, instructions for use: method and dosage
Spazoverin tablets should be taken orally.
In the form of a solution for adult patients, Spazoverin is administered subcutaneously or intramuscularly at 40–80 mg (2–4 ml) 1 to 3 times a day. The duration of treatment is 1-2 weeks, if necessary, the course is extended. If a longer treatment is required, then they switch to taking the drug inside.
To accelerate the achievement of the effect, you can slowly intravenously inject 2-4 ml of the drug in 10-20 ml of isotonic sodium chloride 0.9% solution or 5% dextrose solution.
Recommended dosage for all forms of Spazoverin release:
- children under 6 years old - 10–20 mg 1-2 times a day;
- children from 6 to 12 years old - 20 mg 1-2 times a day;
- adolescents over 12 years old and adults - 40-80 mg 2-3 times a day.
Side effects
In some cases, the drug causes the following side effects: sweating, fever, palpitations, arterial hypotension, dizziness, allergic skin reactions.
Overdose
When used in high doses, Spazoverin reduces the excitability of the heart muscle and disrupts atrioventricular conduction, can cause paralysis of the respiratory center and cardiac arrest.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
In some patients, Spazoverin causes dizziness, this should be taken into account by motor vehicle drivers and persons employed in potentially hazardous industries that require speed of reactions and increased attention.
Application during pregnancy and lactation
Pregnant and lactating women should use the drug with caution.
Pediatric use
In pediatric practice, Spazoverin is used according to indications, according to the dosage regimen prescribed by the doctor.
With impaired renal function
It is contraindicated to use Spazoverin for the treatment of patients with severe renal impairment.
For violations of liver function
It is contraindicated to use Spazoverin for the treatment of patients with severe hepatic impairment.
Drug interactions
With the simultaneous use of Spazoverin:
- may reduce the antiparkinsonian effect of levodopa;
- reduces the spasmogenic activity of morphine;
- increases the action of bendazole, papaverine and other antispasmodics (including M-anticholinergics);
- enhances hypotension caused by procainamide, quinidine, tricyclic antidepressants.
Phenobarbital increases the severity of the antispasmodic effect of drotaverine.
Analogs
Analogs of Spazoverin are Galidor, Dibazol, Drotaverin, Duspatalin, Niaspam, No-Shpa, Papaverin, Papazol, Spazmol, Spazmonet, Spazmoverin, Sparex and others.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° C in a dry place out of the reach of children.
Shelf life of tablets - 3 years, solution - 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Spazoverin
There are no reviews of Spazoverin on specialized sites and forums. This drug contains drotaverine as an active substance, about which there are many positive reports: it quickly and effectively eliminates pain and relieves spasms of smooth muscles in various diseases.
Price for Spazoverin in pharmacies
The approximate price for Spazoverin is 117–130 rubles. per pack of 30 tablets of 40 mg.
The solution for injection is not available for sale, since the term of its state registration has expired.
Spazoverin: prices in online pharmacies
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Drug name Price Pharmacy |
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Spazoverin 40 mg tablets 30 pcs. 142 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
