Calcium Hopantenate

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Calcium hopantenate: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. In case of impaired renal function
12. Drug interactions
13. Analogs
14. Terms and conditions of storage
15. Terms of dispensing from pharmacies
16. Reviews
17. Price in pharmacies

Latin name: Calcium hopantenate

ATX code: N06BX

Active ingredient: hopantenic acid

Producer: Pharmstandard-Ufa Vitamin Plant, JSC (Russia)

Description and photo update: 2018-21-11

Prices in pharmacies: from 185 rubles.

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Calcium hopantenate is a nootropic drug.

Release form and composition

Calcium hopantenate is available in the form of tablets: white, flat-cylindrical, with a dividing line and a chamfer (50 pcs. In polymer cans, 1 can in a cardboard box).

1 tablet contains:

active substance: calcium hopantenate - 0.25 g or 0.5 g;
auxiliary components: potato starch, basic magnesium carbonate, talc, calcium stearate.

Pharmacological properties

Pharmacodynamics

Calcium hopantenate is a drug with nootropic and anticonvulsant action, which is due to the effect of hopantenic acid directly on the GABA _b -receptor-channel complex. A direct effect on receptors increases the resistance of the brain to the effects of toxic substances and hypoxia, stimulates anabolic processes in neurons. A moderate sedative effect is combined with a mild stimulating effect. Reduced motor excitability, increased mental and physical performance.

Taking the drug normalizes the content of GABA (gamma-aminobutyric acid) when ethanol is discontinued in patients with chronic alcohol intoxication. By inhibiting the acetylation reaction of novocaine and sulfonamides, it helps to prolong their action. It has a depressing effect on the pathologically increased gallbladder reflex and detrusor tone.

Pharmacokinetics

After oral administration, rapid absorption from the gastrointestinal tract occurs. The maximum concentration (C _max) of calcium hopantenate in the blood is reached after 1 hour. The highest concentrations of the drug are determined in the wall of the stomach, liver, kidneys and skin. Overcomes the blood-brain barrier.

It is completely excreted unchanged within 48 hours. 67.5% is excreted through the kidneys, 28.5% of the dose taken through the intestines.

Indications for use

cognitive impairment caused by organic damage to the brain, including the consequences of traumatic brain injury, neuroinfection;
cerebrovascular insufficiency due to atherosclerotic changes in the vessels of the brain;
schizophrenia with cerebral organic failure;
extrapyramidal disorders, including Parkinson's disease, myoclonic epilepsy, hepatolenticular degeneration, Huntington's syndrome;
epilepsy with retarded mental processes - in combination with anticonvulsants;
neurogenic disorders of urination: pollakiuria, enuresis, urinary incontinence, urgency;
psychoemotional overload, decreased mental and physical performance - to increase concentration and memorization;
perinatal encephalopathy, developmental delay (motor, mental, speech, or their combination), varying degrees of mental retardation, cerebral palsy, hyperkinetic disorders (tics, attention deficit hyperactivity disorder), neurosis-like states, stuttering (predominantly clonic form) - in children over three years old.

Contraindications

acute period of severe kidney disease;
I trimester of pregnancy;
age up to 3 years;
individual intolerance to the components of the drug.

Instructions for use of Calcium hopantenate: method and dosage

The tablets are taken orally, preferably in the first half of the day, 15-30 minutes after meals.

Recommended dosage:

epilepsy: adults - 0.5-1 g 3-4 times a day, children - 0.25-0.5 g 3-4 times a day, course duration - up to 180 days;
hyperkinesis: adults - 1.5–3 g per day for 30–150 days, children - 0.25–0.5 g 3–6 times a day, course duration - 30–120 days;
mental retardation, mental disability: children - 0.5 g 4-6 times a day, course duration - 90 days;
delayed speech development in children: 0.5 g 3-4 times a day, course duration - 60-90 days;
consequences of craniocerebral trauma and neuroinfections: 0.25 g 3-4 times a day;
restoration of working capacity in asthenic conditions and increased loads: 0.25 g 3 times a day;
treatment of extrapyramidal syndrome caused by taking antipsychotics: adults - 0.5-1 g 3 times a day, children - 0.25-0.5 g 3-4 times a day, course duration - 30-90 days;
tics: adults - 1.5–3 g per day for 30–150 days, children - 0.25–0.5 g 3–6 times a day for 30–120 days;
disorder of urination: adults - 0.5-1 g 2-3 times a day, children - 0.25-0.5 g 2-3 times a day.

The use of Calcium hopantenate is indicated as monotherapy and as part of complex treatment. Treatment should be carried out by increasing the dose for 7-12 days to the maximum dose. After taking the established dose for the required period, the drug is discontinued by gradually decreasing the dose over 7–8 days. After a 30–90 day break, the course of therapy can be resumed.

Side effects

Due to its low toxicity, the drug is well tolerated. Development of allergic reactions in the form of skin rashes, rhinitis, conjunctivitis is possible, which requires discontinuation of the drug. Undesirable effects associated with sleep disturbances, drowsiness, and noise in the head are usually short-term and allow the continuation of Calcium hopantenate intake.

Overdose

Symptoms: Worsening symptoms of adverse events.

Treatment: immediate gastric lavage, activated charcoal intake, symptomatic therapy.

special instructions

You cannot take pills without a doctor's recommendation!

In conditions of long-term treatment, the simultaneous use of Calcium hopantenate with other nootropic drugs or drugs that stimulate the central nervous system should not be allowed.

Application during pregnancy and lactation

The use of hopantenic acid in the first trimester of pregnancy is contraindicated.

Pediatric use

According to the instructions, Calcium hopantenate is indicated for children over three years of age for the treatment of perinatal encephalopathy, various forms of cerebral palsy, neurosis-like conditions, mental retardation of varying severity, hyperkinetic disorders (attention deficit hyperactivity disorder, tics), stuttering (predominantly clonic form), with delayed speech, mental, motor development, or a combination thereof. At an earlier age, the drug should be used in the form of a syrup.

The use of tablets in children under the age of three is contraindicated.

With impaired renal function

The use of the drug is contraindicated during an exacerbation of severe kidney disease.

Drug interactions

With the simultaneous use of Calcium hopantenate:

glycine, etidronic acid enhance the action of hopantenic acid;
barbiturates prolong their action;
local anesthetics (procaine), anticonvulsant drugs, stimulants of the central nervous system enhance their effect;
phenobarbital, carbamazepine, antipsychotics (antipsychotics) reduce the likelihood of developing their side effects.

Analogs

Analogues of Calcium hopantenat are: Pantogam, Gopantam, Pantocalcin, Calcium Hopantenat-Ros, Phezam, Piracesin, Carnicetin, Acefen, Bravinton.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 25 ° C, protected from moisture and light.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Calcium hopantenate

Reviews of Calcium hopantenate are mostly positive. More often they are left by mothers whose children were prescribed the drug for various clinical indications, indicating a positive dynamics of therapy. In case of hyperactivity, the effect of the drug is manifested in a calmer behavior of the child, his ability to concentrate, an adequate response to requests and requests from parents. A decrease in psycho-emotional stress, an improvement in muscle tone, mental and speech development of the child are noted.

The advantages of the drug include a small list of contraindications and side effects. The neutral taste of the tablets does not cause resistance in children when they are taken.

In some cases, against the background of the use of the drug, the child may experience increased agitation.

Discontinuation of Calcium hopantenate can sometimes be accompanied by withdrawal symptoms in the form of weakness.

Price for Calcium hopantenate in pharmacies

The price of Calcium hopantenate for a package containing 50 tablets in a dose of 0.25 g can range from 251 rubles.