Kalcemin Advance
Kalcemin Advance: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Сalcemin Advance
ATX code: A12AX
Active ingredient: Combined preparation
Manufacturer: Sagmel, USA
Description and photo update: 2018-22-10
Prices in pharmacies: from 300 rubles.
Buy
Calcemin Advance is a complex drug that affects phosphorus-calcium metabolism.
Release form and composition
The dosage form of Calcemin Advance is film-coated tablets: pink, biconvex, oval, on one side with a risk (30, 60 or 120 pcs. In polyethylene bottles, 1 bottle in a cardboard box).
Active ingredients in 1 tablet:
- calcium (in the form of calcium citrate tetrahydrate and calcium carbonate) - 500 mg;
- magnesium (as magnesium oxide) 40 mg
- colecalciferol (vitamin D 3) - 200 IU (international units);
- copper (in the form of copper oxide) - 1 mg;
- zinc (in the form of zinc oxide) - 7.5 mg;
- boron (in the form of sodium borate decahydrate) - 0.25 mg;
- manganese (as manganese sulfate) 1.8 mg
Auxiliary components:
- core: sodium lauryl sulfate - 5 mg; maltodextrin - 25 mg; soy polysaccharide - 15 mg; microcrystalline cellulose - 49.05 mg; stearic acid - 16.3 mg; croscarmellose sodium - 38 mg;
- shell: mineral oil - 2.845 mg; titanium dioxide - 12.643 mg; hypromellose - 26.328 mg; magnesium silicate - 5 mg; triacetin - 5.689 mg; aluminum varnish based on dye red charming (Red No. 40) - 0.316 mg; brilliant blue dye-based aluminum varnish (Blue No. 1) - 0.04 mg; aluminum varnish based on dye sunset yellow (Yellow No. 6) - 0.079 mg.
Pharmacological properties
Pharmacodynamics
Calcemin Advance is one of the combined preparations containing vitamins, macro- and microelements. Its action is due to the properties of the components that make up it:
- colecalciferol: required for the metabolism of phosphorus and calcium in the body, helps to preserve the structure of bones, takes part in the formation of the bone skeleton, enhances the absorption of calcium in the intestine and reabsorption of phosphorus in the renal tubules;
- calcium: takes part in the formation of bone tissue, reduces resorption and increases bone density, prevents the development of diseases of the musculoskeletal system, helps to strengthen joints and the skeletal system. Calcium citrate ensures the absorption of calcium, regardless of the functional state of the digestive system, which is applicable for the treatment of patients with reduced secretory function of the gastrointestinal tract, as well as during therapy with drugs to reduce secretion; lowers the level of markers of bone resorption, which indicates a slowdown in the process of destruction of bone tissue; regulates the content of parathyroid hormone, which leads to an improvement in the regulation of calcium homeostasis. It does not lead to an increase in the content of calcium and oxalates in the urine, therefore, the formation of kidney stones does not cause;iron absorption does not block, which reduces the likelihood of iron deficiency anemia;
- zinc: has a beneficial effect on bone density, promotes the synthesis of sex hormones, which is an obstacle to the destruction of bone tissue;
- magnesium: takes part in the formation of bone and muscle tissues, as well as in protein synthesis (including type I collagen);
- boron: lowers the excessive activity of parathyroid hormone, helps prevent osteoporosis, improves calcium absorption, and reduces the risk of cholecalciferol deficiency;
- magnesium and zinc: required for the synthesis of organic bone matrix;
- copper: takes part in the synthesis of collagen and elastin, which is part of the connective and bone tissue, influencing the formation of bone mass;
- manganese: takes part in the formation of proteoglycans, which leads to an improvement in the quality of bone tissue and forms the collagen (protein) matrix of bone tissue.
Indications for use
- therapy of diseases of the musculoskeletal system (in order to improve the consolidation of traumatic fractures);
- complex treatment and prevention of osteoporosis of various etiologies in women during surgical / natural menopause, as well as with prolonged use of glucocorticosteroids and immunosuppressants;
- replenishment of the deficiency of trace elements and calcium in adolescent patients.
Contraindications
Absolute:
- renal failure in severe course;
- hypervitaminosis of vitamin D;
- urolithiasis disease;
- hypercalciuria;
- hypercalcemia;
- active tuberculosis;
- sarcoidosis;
- allergy to soy and peanut butter;
- age up to 12 years;
- individual intolerance to the components of the drug.
Relative (diseases / conditions in the presence of which the appointment of Calcemin Advance requires caution):
- renal failure;
- pregnancy and the period of breastfeeding.
Instructions for the use of Calcemin Advance: method and dosage
According to the instructions, Calcemin Advance is taken orally, preferably with meals.
Recommended dosage regimen:
- osteoporosis (as part of complex treatment): 2 times a day, 1 tablet, the average duration of use is 3 months;
- osteoporosis (prevention): 1 tablet once a day, the average duration of use is 2 months;
- improving the consolidation of traumatic fractures, replenishing the deficiency of trace elements and calcium in adolescents over 12 years old: 1 tablet once a day, the average duration of use is 1–1.5 months.
Side effects
- digestive system: diarrhea, vomiting, nausea, flatulence, constipation;
- metabolism: hypercalciuria, hypercalcemia;
- allergic reactions: rash, itching, urticaria.
Overdose
An overdose of Calcemin Advance can cause vitamin D 3 hypervitaminosis, hypercalciuria and hypercalcemia.
The main symptoms: constipation, vomiting, nausea, decreased appetite, thirst, polyuria, muscle weakness, dizziness, headache, fainting, coma, bone pain, fatigue, nephrocalcinosis, mental disorders, urolithiasis, abdominal pain; in severe cases, cardiac arrhythmias; with prolonged use of calcium in doses of more than 2500 mg - calcification of soft tissues, kidney damage.
Therapy: when the first signs of an overdose appear, a reduction in the dose of the drug or its temporary cancellation is required. In case of accidental overdose, induce vomiting, rinse the stomach. If necessary, symptomatic therapy is carried out.
For hypercalciuria exceeding 7.5 mmol per day (300 mg per day), the dose of Calcemin Advance should be reduced or treatment canceled. Recommended rehydration, the use of "loop" diuretics (for example, furosemide), glucocorticosteroids, bisphosphonates, calcitonin, in severe cases, hemodialysis is prescribed.
special instructions
You should not exceed the recommended dose of Calcemin Advance in the instructions, since an increased intake of calcium can cause inhibition of the absorption of zinc, iron and other essential minerals in the intestine.
Application during pregnancy and lactation
During pregnancy and lactation, you should consult your doctor before taking Calcemin Advance.
It should be taken into account that the daily dose for pregnant women should not exceed 1500 mg of calcium and 600 IU of vitamin D 3, since an overdose during pregnancy can cause defects in the physical and mental development of the child.
Colecalciferol and its metabolites are excreted in breast milk, which should be taken into account when adding calcium and vitamin D 3 to the child.
Pediatric use
Calcemin Advance is not prescribed for children under 12 years old.
With impaired renal function
- severe renal failure, urolithiasis: use is contraindicated;
- renal failure: therapy can be performed with caution.
Drug interactions
With the combined use of Calcemin Advance with some drugs / substances, the following effects may develop:
- vitamin A: reducing the toxicity of vitamin D 3;
- laxative agents: reducing the absorption of vitamin D 3;
- barbiturates, phenytoin, glucocorticoids: decrease in the effectiveness of vitamin D 3;
- antibacterial drugs of the tetracycline group: violation of their absorption (the interval between taking these drugs should be at least 3 hours);
- glucocorticoids, levothyroxine, hormonal contraceptives for systemic use: decreased absorption of calcium ions;
- cardiac glycosides: an increase in their toxicity (monitoring of the clinical condition and ECG is required);
- bisphosphonates and sodium fluoride: violation of their absorption (the interval between taking these drugs should be at least 2 hours);
- furosemide and other "loop" diuretics: increased renal excretion of calcium;
- thiazide diuretics: increasing the likelihood of hypercalcemia;
- antacids with aluminum content: decrease in their effectiveness (the combination is not recommended);
- calcium channel blockers: the combination is not recommended.
Analogs
An analogue of Kalcemin Advance is Kalcemin.
Terms and conditions of storage
Store in a place protected from moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Kalcemin Advance
According to reviews, Calcemin Advance is an effective drug. They note its affordable cost, balanced composition, informational content of packaging and ease of use. Of the shortcomings, the large size of the tablets is most often indicated.
Price for Calcemin Advance in pharmacies
The approximate price for Calcemin Advance (30, 60 or 120 tablets per pack) is 440-450, 620-700 or 845-930 rubles.
Kalcemin Advance: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Calcemin Advance film-coated tablets 30 pcs. RUB 300 Buy |
|
Calcemin Advance tablets p.o. 30 pcs. 423 r Buy |
|
Calcemin Advance film-coated tablets 60 pcs. RUB 590 Buy |
|
Calcemin Advance tablets p.o. 60 pcs. RUB 616 Buy |
|
Calcemin Advance film-coated tablets 120 pcs. 809 RUB Buy |
|
Calcemin Advance tablets p.o. 120 pcs. RUB 830 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
