Aldazol - Instructions For Use Of The Drug, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Aldazole

Aldazol: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Drug interactions
10. Analogs
11. Terms and conditions of storage
12. Terms of dispensing from pharmacies
13. Reviews
14. Price in pharmacies

Latin name: Aldazole

ATX code: P02SA03

Active ingredient: albendazole (albendazole)

Manufacturer: PJSC "Kiev Vitamin Plant" (Ukraine)

Description and photo update: 2019-19-08

Aldazole is an anthelmintic drug.

Release form and composition

Dosage form of Aldazol - film-coated tablets: almost white or white, round biconvex (3 pcs. In a blister, 1 blister in a cardboard box).

1 tablet contains:

active substance: albendazole - 400 mg;
auxiliary components: corn starch, povidone, sodium lauryl sulfate, methylparaben (E 218), colloidal anhydrous silicon dioxide, propylparaben (E 216), sodium starch glycollate, magnesium stearate, gelatin, talc;
film casing - Opadry II White.

Pharmacological properties

Aldazole is characterized by antihelminthic and antiprotozoal action. It is intended for the treatment of diseases caused by the activity of tissue or intestinal parasites in the form of adult helminths, larvae or eggs.

Pharmacodynamics

The action of albendazole is due to the suppression of tubulin polymerization, which leads to disruption of metabolic processes in the body of parasites and their subsequent death. The following parasites are susceptible to the action of this drug: Gnathostoma spinigerum (causes gnatostomosis), Capillaria philippinensis (causes capillariasis), Taenia solium (causes neurocysticercosis), Echinococcus multilocularis and Echinococcus granulosus (causes cystic and alveolar echinococcus).

Also albendazole works well on protozoa [Giardia lamblia (duodenalis or intestinalis)], nematodes (Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Cutaneous Larva Migrans, Strongyloides stercoralis, Tacator americanus, Enterobius vermicularis), cestodes trematodes (Clonorchis sinensis, Opisthorchis viverrini).

Pharmacokinetics

The intestinal absorption of albendazole is less than 5%. With the simultaneous administration of Aldazole with fatty foods, its bioavailability increases by about 5 times. The main metabolite is albendazole sulfate, which has an anthelmintic effect on tissue parasites. The half-life of the active substance is 8.5 hours. Albendazole is mainly excreted in bile and urine.

Indications for use

nematodes: enterobiasis, ankylostomiasis, ascariasis, necatorosis, teniasis, trichinosis, clonorchiasis, opisthorchiasis;
giardiasis;
strongyloidosis;
toxocariasis;
neurocysticercosis;
cutaneous migratory larvae (Cutaneous Larva Migrans);
echinococcosis of the lungs, peritoneum or liver caused by the larval form of the canine tapeworm (Echinococcus granulosus).

Contraindications

retinal damage;
the period of pregnancy and breastfeeding;
a period lasting one menstrual cycle before a planned pregnancy;
age up to 3 years;
individual intolerance to albendazole or auxiliary components of Aldazole.

According to the instructions, Aldazol should be prescribed with caution to patients with depressed marrow hematopoiesis, cirrhosis of the liver, hepatic failure, cysticercosis involving the retina of the eye.

Instructions for the use of Aldazole: method and dosage

Aldazol tablets are taken orally during meals, preferably oily, swallowing whole and drinking plenty of water.

The doctor prescribes the dose and the period of treatment based on clinical indications, confirmed by the results of laboratory tests.

The recommended dosage regimen of Aldazole for adults and children:

enterobiasis, ascariasis, ankylostomiasis, trichinosis, necatorosis: 400 mg (1 pc.) once. After a 21-day break, the course of treatment should be repeated. With enterobiasis, it is recommended to treat all persons living together at the same time;
cutaneous migratory larvae: 400 mg once a day for 1-3 days;
clonorchiasis, opisthorchiasis: 400 mg 2 times a day, the course of treatment is 3 days;
neurocysticercosis: patients with a body weight of up to 60 kg are prescribed at the rate of 15 mg per 1 kg of body weight per day, with a body weight above 60 kg - 800 mg (2 pcs.) per day. The daily dose is divided into 2 doses in equal shares, the duration of the course depends on the effectiveness of therapy and can range from 7 to 30 days. To achieve a sufficient therapeutic effect, the course of treatment can be repeated after 1–2 weeks;
teniasis, strongyloidosis (suspected or diagnosed): 400 mg once a day, duration of administration - 3 days, after 21 days the course of treatment should be repeated;
alveolar echinococcosis: with a body weight of up to 60 kg - 15 mg per 1 kg of weight, with a weight of more than 60 kg - 800 mg. The prescribed dose is divided into 2 doses per day, taken within 28 days (1 course). This is followed by a break of 14 days. The course is repeated 3 times. To achieve a clinical effect, treatment can take a long time, up to several years;
cystic echinococcosis: with a patient's body weight up to 60 kg - 15 mg per 1 kg, with a body weight of more than 60 kg - 800 mg. The daily dose is divided into 2 doses, the course of treatment is 28 days. If necessary, the course can be repeated at intervals of 14 days 3 times;
toxocariasis: 10 mg per 1 kg of body weight per day, the dose is divided into 2 doses, morning and evening. The course of treatment is 10–20 days;
giardiasis: children aged 3 to 12 years: 400 mg 1 time per day, course duration - 5 days.

The daily dose of Aldazole should not exceed 800 mg.

Side effects

from the digestive system: dry mouth, stomatitis; rarely - abdominal pain, nausea, vomiting, dyspepsia, diarrhea, constipation, flatulence, abnormal liver function, changes in the activity of liver enzymes; with prolonged therapy in high doses - jaundice;
from the hematopoietic system: pancytopenia, leukopenia, agranulocytosis, granulocytopenia, thrombocytopenia;
from the nervous system: drowsiness or insomnia (mild and quickly passing), headache, confusion, dizziness, disorientation, convulsions, hallucinations, fatigue, decreased visual acuity; rarely - excitement;
from the musculoskeletal system: joint pain, muscle pain, acute attack of gout, joint inflammation;
from the urinary system: acute renal failure; in men - urinary disorders;
dermatological reactions: photodermatosis;
allergic reactions: pruritus, rash, dermatitis, urticaria, fever, pemphigus, angioedema;
others: reversible alopecia, increased blood pressure, hyperthermia, menstrual irregularities.

Overdose

Symptoms of an overdose of the drug Aldazol are: an increased level of liver enzymes, sleep disturbances, staining of the skin, lacrimal fluid, saliva and urine in an orange or brownish-red tint, vomiting, blurred vision, visual hallucinations, tachycardia, jaundice, an increase in liver size. In this case, it is necessary to immediately cancel the drug, rinse the stomach and take any enterosorbent. If necessary, symptomatic therapy is prescribed.

special instructions

When prescribing high doses of Aldazole, the patient must be provided with careful medical supervision, including regular monitoring of the state of liver and blood function.

Before starting treatment of patients with neurocysticercosis with eye damage, a study of the retina of the eye should be carried out so that the intake of Aldazol does not cause an aggravation of the pathology. With neurocysticercosis, concomitant therapy with anticonvulsants and glucocorticoid drugs should be used, this will reduce the risk of a hypertensive attack in the first week of anticystic therapy.

It is required to control the number of leukocytes at the beginning of treatment and every 14 days with a 28-day therapy cycle. If the decrease in the level of white blood cells is insignificant and the process does not progress, treatment can be continued. When the patient develops severe leukopenia, the drug Aldazol should be canceled.

Monitoring the activity of hepatic transaminases should be carried out at the beginning of each course of treatment. If the upper limit of the enzyme activity rate is 2 times exceeded, it is necessary to suspend the intake of Aldazol until they are completely normalized.

During the period of albendazole use, the patient should not engage in activities related to the management of vehicles and mechanisms.

Drug interactions

With simultaneous use with cimetidine, dexamethasone and praziquantel, the concentration of albendazole metabolites in the blood increases.

As an inducer of microsomal cytochrome P ₄₅₀ enzymes, Aldazol accelerates the metabolism of many drugs.

Long-term administration of albendazole inhibits the N-demethylation of aminopyrine, which causes a gradual decrease in the level of albendazole sulfoxide.

Analogs

Analogues of Aldazole are: Vormil, Albendazole, Sanoxal, Farmoks, Zentel, Nemozol, Medamin, Vermakar, Vermox, Mebendazole, Vormin.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Aldazol

Almost all reviews of Aldazole indicate its high efficiency and almost complete absence of side reactions. It helps get rid of worms and other parasites in record time. However, in some patients, its reception was still accompanied by negative symptoms (headache, nausea, vomiting).

The price of Aldazol in pharmacies

On average, the price of Aldazol in pharmacy chains is 270 rubles (per package containing 3 tablets).

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!