Colofort
Kolofort: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Kolofort
ATX code: A03A, A03AE, A03C
Active ingredient: affinity purified antibodies to histamine, to human tumor necrosis factor alpha (TNF-α), to brain-specific protein S-100
Producer: NPF Materia Medica Holding, LLC (Russia)
Description and photo update: 2019-08-07
Prices in pharmacies: from 351 rubles.
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Kolofort is a drug with anti-inflammatory, antispasmodic and anxiolytic effects.
Release form and composition
The drug is produced in the form of tablets for resorption: flat-cylindrical, almost white or white, with a risk and a chamfer; on the side with a line the inscription "MATERIA MEDICA" is applied, on the other side - "KOLOFORT" (in a cardboard box 1, 2 or 5 cell contour packs of 20 tablets each and instructions for the use of Kolofort).
Composition of 1 tablet:
- active substances: affinity purified antibodies * to histamine - 0.006 g, affinity purified antibodies * to brain-specific protein S-100 - 0.006 g, affinity purified antibodies * to human tumor necrosis factor alpha (TNF-α) - 0.006 g;
- auxiliary components: lactose monohydrate, magnesium stearate, microcrystalline cellulose.
* They are applied to lactose in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted 100 200, 100 30 and 100 12 times, respectively.
Pharmacological properties
Pharmacodynamics
It has been experimentally established that the active components of Kolofort modify the activity of ligand-receptor interaction of endogenous regulators with the corresponding receptors: antibodies to histamine - to histamine H 4 receptors located in the gastrointestinal tract (GIT), antibodies to TNF-α - to the TNF-α receptor, antibodies to protein S-100 - to serotonin receptors and σ 1 receptors.
Due to the combination of three components, Kolofort has a complex effect on the peripheral and central links in the pathogenesis of functional intestinal disorders, including abdominal pain syndrome.
Properties of the active substances of the drug:
- antibodies to histamine have antispasmodic, anti-edematous and anti-inflammatory effects;
- antibodies to TNF-α have a pronounced anti-inflammatory effect, help to normalize the balance of pro-inflammatory and anti-inflammatory cytokines;
- antibodies to the S-100 protein have a wide spectrum of psychotropic activity, including anxiolytic, antidepressant, nootropic and antiasthenic effects, which in therapeutic practice is manifested by the elimination of anxiety and internal tension, as well as the normalization of a number of visceral functions, including the activity of the large intestine. They are not sedative, addictive and non-withdrawal.
Due to the properties of active ingredients, Kolofort normalizes nervous and humoral regulation of intestinal function, reduces visceral hypersensitivity of colon receptors to stretching, reduces the severity of pain syndrome, relieves the feeling of stomach overflow and bloating, and provides restoration of impaired gastrointestinal motility.
The antispasmodic effect of the drug is expressed in relaxation of smooth muscles and a decrease in the tone of the gastrointestinal tract wall, a decrease in intraluminal pressure, normalization of stool frequency, its consistency and accompanying symptoms (relief of the feeling of incomplete bowel movement, tenesmus, imperative urge, additional efforts during the act of defecation, etc.).
Pharmacokinetics
The study of the pharmacokinetics of Kolofort is technically impossible, since biological fluids, tissues and organs contain ultra-low doses of antibodies that are not determined by modern physicochemical methods of analysis, such as chromatography-mass spectrometry, gas-liquid chromatography and high-performance liquid chromatography.
Indications for use
- functional disorders of the gastrointestinal tract;
- irritable bowel syndrome.
Contraindications
Kolofort tablets are contraindicated in case of increased individual sensitivity to their components.
Kolofort, instructions for use: method and dosage
The drug is taken orally between meals. The tablets should be kept in the mouth until they are completely dissolved.
The recommended dose is 1-2 tablets 2 times a day. During an exacerbation of the disease, a temporary (for 7-14 days) increase in the frequency of taking the drug up to 4 times a day is possible.
The duration of treatment is 1–3 months. If necessary, the course is extended up to 6 months and / or repeated after 1–2 months.
Side effects
Against the background of the use of Kolofort, the development of reactions of individual hypersensitivity to the components of the drug is possible.
Overdose
In case of overdose, dyspeptic disorders may occur.
Treatment is symptomatic.
special instructions
Colofort tablets contain lactose, therefore they are not recommended for patients with congenital lactase deficiency, glucose / galactose malabsorption syndrome, congenital galactosemia.
Influence on the ability to drive vehicles and complex mechanisms
The components of the drug do not have the ability to negatively affect the cognitive and psychomotor functions of a person.
Drug interactions
Cases of drug interactions with negative consequences have not yet been registered.
Analogs
Kolofort analogues are: Artrofoon, Glytsiram, Cuprenil, Piaskledin 3000, Rumalaya, etc.
Terms and conditions of storage
Store in a dark place, out of the reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Kolofort
Reviews about Kolofort are contradictory. In positive messages, patients note the effectiveness of the drug in functional disorders of the gastrointestinal tract and irritable bowel syndrome. They write that the course of treatment helped eliminate pain and bloating, and restored the digestive tract. Additional advantages include the pleasant taste of the tablets, convenient dosage form, no contraindications, and affordable cost. The disadvantages, according to some, are the delayed onset of the therapeutic effect, the long duration of therapy and, as a consequence, the high cost of the drug for the full course.
In negative messages, most often patients complain of a complete lack of effect from taking the drug.
The price of Kolofort in pharmacies
Depending on the pharmacy chain, the price of Kolofort for a pack of 100 tablets can range from 330 to 471 rubles.
Kolofort: prices in online pharmacies
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Drug name Price Pharmacy |
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Colofort tablets for resorption 100 pcs. 351 r Buy |
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Colofort tablets for rassas. 100 pieces. 450 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
