Clomid
Clomid: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Clomid
ATX code: G03GB02
Active ingredient: clomiphene (clomifene)
Producer: Bruno Farmaceutici SpA (Italy), Marion Merrell Burgoin (France)
Description and photo update: 2019-26-08
Clomid is an antiestrogenic agent.
Release form and composition
Dosage form - tablets (10 pcs. In blisters, in a box of 10 blisters).
The active ingredient is clomiphene citrate, in 1 tablet - 50 mg.
Pharmacological properties
Pharmacodynamics
Clomid is a non-steroidal antiestrogenic drug.
Stimulates the ovulation process, while the exact mechanism of action remains unclear. It is assumed that the active substance of the drug, clomiphene, blocks estrogen receptors in the ovaries and hypothalamus and, through feedback, enhances the synthesis of gonadotropic hormones (luteinizing hormone and follicle-stimulating hormone) by the pituitary gland. In turn, this has a stimulating effect on the maturation and endocrine activity of the follicle in the ovary, and then on the formation and functioning of the corpus luteum.
Pharmacokinetics
After oral administration, clomiphene is rapidly absorbed from the gastrointestinal tract. At the end of 5-day therapy, its cumulative excretion is 50% of the dose taken (42.2% - with feces, 7.8% - with urine). In the period from the 31st to the 35th day of therapy, 0.73% of the dose of the drug is excreted daily with feces and urine, and from the 42nd to 45th day of therapy - 0.54% each.
Indications for use
The use of the drug is indicated for the stimulation of ovulation in infertility against the background of secondary hypofunction of the ovaries, mainly due to disorders of the hypothalamic-pituitary system.
Contraindications
- Uterine bleeding of unknown etiology;
- Severe renal and / or hepatic impairment;
- Ovarian cyst;
- Bleeding;
- Lack of function or swelling of the pituitary gland;
- Pregnancy period.
Instructions for the use of Clomid: method and dosage
Clomid tablets are used orally.
You should start taking it from the fifth day of the menstrual cycle.
Recommended dosage: first cycle - 50 mg once a day for 5 days. When ovulation appears on subsequent cycles of therapy, an increase in dose is not required.
In the absence of a clinical effect in the first cycle, after 30 days, a second cycle of treatment should be carried out with the appointment of a daily dose of 100 mg for 5 days. An extension of the course of therapy or an increase in the dose in the second cycle should not be performed.
For most women, a full course of 3 cycles is effective. In the absence of ovulation, it is impractical to continue treatment.
Side effects
- Cystic enlargement of the ovaries;
- Hot flashes;
- Nausea;
- Dizziness, headache;
- Visual impairment.
Overdose
The main symptoms: visual disturbances, flushing of the face, nausea, vomiting.
Therapy: cancellation of Clomid, symptomatic treatment.
special instructions
The drug should be used only as directed by a doctor.
Application during pregnancy and lactation
According to the instructions, Clomid is not prescribed during pregnancy and lactation.
With impaired renal function
Drug therapy for severe renal failure is contraindicated.
For violations of liver function
Drug therapy with severe hepatic failure is contraindicated.
Drug interactions
Clinically significant interaction of Clomid when combined with other drugs has not been established.
Analogs
Clomid's analogues are: Clomiphene citrate, Clomiphene, Serofen, Klostilbegit, Serpafar.
Terms and conditions of storage
Keep out of the reach of children.
Store in a dry, protected from direct sunlight at temperatures up to 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Clomid reviews
Reviews of Clomid are few. In most cases, the high efficacy of the drug is noted, although there are also women for whom the therapeutic effect was insufficient. There are reports of the development of adverse reactions, usually in the form of pain in the lower abdomen.
The price of Clomid in pharmacies
The price of Clomid is unknown, since the drug is not available in the pharmacy chain.
The approximate cost of the analogue, the drug Klostilbegit, is 549–650 rubles for 10 tablets of 50 mg each.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
