Formetin
Formetin: instructions for use and reviews
- 1.production and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Formetine
ATX code: A10BA02
Active ingredient: Metformin (Metformin)
Producer: JSC Pharmstandard-Leksredstva (Russia), JSC Pharmstandard-Tomskhimfarm (Russia)
Description and photo update: 2018-24-10
Prices in pharmacies: from 51 rubles.
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Formetin is an oral hypoglycemic agent from the biguanide group.
Release form and composition
Dosage form Formetin - tablets: 500 mg - round, flat-cylindrical, white, with a line and a chamfer; 850 mg and 1000 mg are oval, biconvex, white, with a line on one side. Packing: blisters - 10 pcs., In a cardboard box 2, 6 or 10 packages; 10 and 12 pcs., in a carton box 3, 5, 6 or 10 packs.
Composition of the preparation:
- active substance: metformin hydrochloride, in 1 tablet - 500, 850 or 1000 mg;
- additional components and their content for tablets 500/850/1000 mg: magnesium stearate - 5 / 8.4 / 10 mg, croscarmellose sodium (primellose) - 8 / 13.6 / 16 mg, povidone (povidone K-30, medium molecular weight polyvinylpyrrolidone) - 17/29/34 mg.
Pharmacological properties
Pharmacodynamics
Metformin hydrochloride is the active substance of Formetin, a substance that inhibits gluconeogenesis in the liver, enhances peripheral glucose utilization, reduces the absorption of glucose from the intestine, and increases the sensitivity of body tissues to insulin. In this case, the drug does not affect the secretion of insulin by the beta cells of the pancreas, and also does not cause the development of hypoglycemic reactions.
Metformin lowers the level of low density lipoproteins and triglycerides in the blood. Reduces or stabilizes body weight.
Due to the ability to suppress tissue-type plasminogen activator inhibitor, the drug has a fibrinolytic effect.
Pharmacokinetics
After oral administration, metformin is slowly absorbed from the gastrointestinal tract. After taking a standard dose, bioavailability is about 50-60%. The maximum plasma concentration reaches within 2.5 hours.
Practically does not bind to plasma proteins. Accumulates in kidneys, liver, muscles and salivary glands.
The half-life is from 1.5 to 4.5 hours. It is excreted by the kidneys unchanged. In patients with impaired renal function, metformin accumulation may occur.
Indications for use
Formetin is prescribed for type II diabetes mellitus (non-insulin dependent) patients in whom diet therapy was ineffective, especially for obese patients.
Contraindications
- diabetic ketoacidosis;
- diabetic precoma / coma;
- impaired liver function;
- severe renal dysfunction;
- severe infectious diseases;
- lactic acidosis at present or in history;
- dehydration, acute disturbance of cerebral circulation, acute phase of myocardial infarction, heart and respiratory failure, chronic alcoholism and other diseases / conditions that can contribute to the development of lactic acidosis;
- serious injury or surgery when insulin therapy is indicated;
- acute alcohol poisoning;
- adherence to a hypocaloric diet (less than 1000 kcal / day);
- pregnancy and the period of breastfeeding;
- X-ray / radioisotope studies using iodine-containing contrast agent (within 2 days before and 2 days after);
- hypersensitivity to the drug.
Formetin is not recommended for people over 60 years of age who perform heavy physical work, since they have an increased risk of developing lactic acidosis.
Instructions for the use of Formetin: method and dosage
Formetin tablets are indicated for oral administration. They should be taken whole, without chewing, with plenty of water, during or after meals.
The optimal dosage for each patient is set individually and is determined by the level of glucose in the blood.
At the initial stage of therapy, usually 500 mg is prescribed 1-2 times a day or 850 mg once a day. In the future, no more than 1 time per week, the dose is gradually increased. The maximum allowable dose of Formetin is 3000 mg per day.
Elderly people should not exceed the daily dose of 1000 mg. In severe metabolic disorders due to the high risk of developing lactic acidosis, it is recommended to reduce the dose.
Side effects
- from the endocrine system: when used in inadequate doses - hypoglycemia;
- from the side of metabolism: rarely - lactic acidosis (requires discontinuation of the drug); with prolonged use - hypovitaminosis B 12 (malabsorption);
- on the part of the digestive system: metallic taste in the mouth, diarrhea, lack of appetite, nausea, abdominal pain, flatulence, vomiting;
- on the part of the hematopoietic organs: very rarely - megaloblastic anemia;
- allergic reactions: skin rashes.
Overdose
An overdose of metformin can lead to fatal lactic acidosis. Lactic acidosis can also develop as a result of drug accumulation in patients with impaired renal function. Early signs of this condition are: a decrease in body temperature, general weakness, muscle and abdominal pain, diarrhea, nausea and vomiting, reflex bradyarrhythmia, and a decrease in blood pressure. In the future, dizziness, increased breathing, impaired consciousness, coma are possible.
If symptoms of lactic acidosis appear, you should immediately stop taking Formetin tablets, and the patient should be hospitalized. The diagnosis is confirmed based on lactate concentration data. Hemodialysis is the most effective way to remove lactate from the body. Further treatment is symptomatic.
special instructions
Patients receiving metformin therapy should be closely monitored for renal function. At least 2 times a year, as well as in the case of the development of myalgia, the determination of the plasma lactate content is required.
If necessary, Formetin can be administered in combination with sulfonylurea derivatives. However, treatment must be carried out under close monitoring of blood glucose levels.
During treatment, you should refrain from drinking alcohol, since ethanol increases the risk of developing lactic acidosis.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Formetin, used as a monopreparation, does not affect concentration and reaction speed.
In the case of the simultaneous use of other hypoglycemic agents (insulin, sulfonylurea derivatives, etc.), there is a possibility of hypoglycemic conditions, in which the ability to drive a car and engage in potentially hazardous activities that require the speed of mental and physical reactions, as well as increased attention, deteriorates.
Application during pregnancy and lactation
The period of pregnancy and lactation is a contraindication to the appointment of Formetin.
With impaired renal function
Severe renal dysfunction is a contraindication to the appointment of Formetin.
For violations of liver function
Liver dysfunction is a contraindication to the appointment of Formetin.
Use in the elderly
In old age, the drug should be used with caution. Do not exceed the daily dose of 1000 mg.
For people over 60 years old, engaged in heavy physical labor, Formetin is not recommended to be prescribed because of the increased risk of lactic acidosis.
Drug interactions
The hypoglycemic effect of metformin can be enhanced by sulfonylurea derivatives, non-steroidal anti-inflammatory drugs, clofibrate derivatives, angiotensin-converting enzyme inhibitors, monoamine oxidase inhibitors, adrenergic blockers, oxytetracycline, acarbose, cyclophosphamide, insulin.
The hypoglycemic effect of metformin can be reduced by nicotinic acid derivatives, thyroid hormones, sympathomimetics, oral contraceptives, thiazide and loop diuretics, glucocorticosteroids, phenothiazine derivatives, glucagon, epinephrine.
Cimetidine slows down the elimination of metformin and, as a result, increases the risk of lactic acidosis.
The likelihood of lactic acidosis increases with the simultaneous use of ethanol.
Cationic drugs secreted in the tubules (quinine, amiloride, triamterene, morphine, quinidine, vancomycin, procainamide, digoxin, ranitidine) compete for tubular transport systems, therefore, with prolonged use, they can increase the concentration of metformin by 60%.
Nifedipine enhances the absorption and maximum concentration of metformin, slows down its excretion.
Metformin can reduce the effect of coumarin-derived anticoagulants.
Analogs
Formetin analogs are: Bagomet, Glyformin, Glyformin Prolong, Glucophage, Glucophage Long, Diasfor, Diaformin OD, Metadien, Metfogamma 850, Metfogamma1000, Metformin, Metformin Zentiva, Metformin Long, Metformin Long Canoneva, Metformin MB-S, Metformin MV Canon, Metformin-Richter, Metformin-Teva, Siofor 500, Siofor 850, Siofor 1000, Sophamet, Formetin Long, Formin Pliva.
Terms and conditions of storage
Shelf life - no more than 2 years from the date of production, subject to the recommended storage conditions: dry, protected from light, place inaccessible to children, temperature - up to 25 ° C.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Formetin
Reviews about Formetin on specialized medical forums, left by patients who underwent drug therapy, are contradictory: there are both positive and negative statements. This suggests that this drug is not suitable for everyone, therefore it should be used strictly according to the doctor's prescription.
Price for Formetin in pharmacies
The approximate price for Formetin is:
- tablets 500 mg - 40-60 rubles. for 30 pcs., 75-90 rubles. for 60 pcs.;
- tablets 850 mg - 95-120 rubles. for 30 pcs., 160 rubles. for 60 pcs.;
- tablets 1000 mg - 130-150 rubles. for 30 pcs., 210-240 rubles. for 60 pcs.
Formetin: prices in online pharmacies
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Drug name Price Pharmacy |
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Formetin 500 mg tablets 30 pcs. RUB 51 Buy |
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Formetin tablets 500mg 30 pcs. RUB 53 Buy |
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Formetin 500 mg tablets 60 pcs. 79 RUB Buy |
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Formetin 850 mg tablets 30 pcs. 107 RUB Buy |
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Formetin 1 g tablets 30 pcs. 123 r Buy |
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Formetin 850 mg tablets 60 pcs. 158 RUB Buy |
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Formetin tablets 850mg 60 pcs. RUB 165 Buy |
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Formetin 1 g tablets 60 pcs. 208 RUB Buy |
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Formetin tablets 1g 60 pcs. 236 r Buy |
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Formetin Long tablets p.o. with prolonged release. 500mg 60 pcs. 345 r Buy |
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Formetin Long 500 mg film-coated tablets with extended release 60 pcs. 345 r Buy |
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Formetin Long 750 mg film-coated tablets with extended release 60 pcs. 389 r Buy |
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Formetin Long 1000 mg film-coated tablets with extended release 60 pcs. 535 RUB Buy |
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Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
