Cereton
Cereton: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Cereton
ATX code: N07AX02
Active ingredient: choline alfoscerate (Choline alfoscerate)
Producer: CJSC "PharmFirma" Sotex "(Russia)
Description and photo update: 2018-22-10
Prices in pharmacies: from 159 rubles.
Buy
Cereton is a drug with a nootropic effect.
Release form and composition
Dosage forms of release of Tsereton:
- solution for intravenous (i / v) and intramuscular (i / m) administration: clear colorless liquid (in 4 ml ampoules, in blisters of 3 or 5 ampoules, in a cardboard box 1 or 2 packs);
- capsules: gelatinous soft, oval, yellow or yellow with a light brown tint; the capsules contain a transparent, oily, colorless or slightly colored liquid (14 pcs. in blisters and without cells, in a cardboard box 1-4 packs).
Composition of 1 ml of Cereton solution:
- active substance: anhydrous choline alfoscerate - 250 mg (in the form of choline alfoscerate polyhydrate);
- auxiliary component: water for injection - up to 1 ml.
Composition of 1 capsule Cereton:
- active substance: choline alfoscerate - 400 mg (in terms of 100% substance);
- auxiliary components: glycerol - 50 mg; purified water - in sufficient quantity to obtain a content weight of 590 mg;
- shell: propyl parahydroxybenzoate, gelatin, glycerol, sorbitol, methyl parahydroxybenzoate, titanium dioxide, dye iron oxide yellow, purified water.
Pharmacological properties
Pharmacodynamics
Cereton is one of the nootropic drugs. It is a centrally acting cholinomimetic, which contains 40.5% of metabolically protected choline.
Metabolic protection promotes the release of choline in the brain. The drug has a positive effect on the behavioral and cognitive reactions of patients with vascular diseases of the brain (discirculatory encephalopathy, residual symptoms of cerebrovascular accident), promotes regression of focal neurological symptoms and restoration of consciousness, prophylactically and correctively affects the pathogenetic factors of involutional psychoorganic syndrome.
Other effects of Cereton:
- ensuring the synthesis of phosphatidylcholine and acetylcholine in neuronal membranes;
- improved blood flow and increased metabolic processes in the central nervous system;
- activation of the reticular formation;
- an increase in the linear velocity of blood flow on the side of the traumatic brain injury;
- normalization of spatio-temporal characteristics of spontaneous bioelectric activity of the brain;
- changes in the phospholipid composition of neuronal membranes and a decrease in cholinergic activity;
- stimulation of dose-dependent release of acetylcholine under physiological conditions;
- improvement of synaptic transmission, plasticity of neuronal membranes, receptor function (due to participation in the synthesis of phosphatidylcholine - membrane phospholipid).
Does not affect the reproductive cycle and does not have a mutagenic and teratogenic effect.
Pharmacokinetics
Absorption for parenteral administration is 88%, easily penetrates the blood-brain barrier (concentration in the brain for oral administration is 45% of plasma). It accumulates mainly in the liver, brain and lungs.
85% of the drug is excreted by the lungs in the form of carbon dioxide, the rest of the substance is excreted through the intestines and kidneys.
Indications for use
- psychoorganic syndrome that occurs during involutional and degenerative changes in the brain;
- recovery / acute period of ischemic stroke and severe traumatic brain injury, recovery period of hemorrhagic stroke, which occur with focal hemispheric symptoms or symptoms of brain stem damage;
- senile pseudomelancholia;
- cognitive disorders, including impaired memory, mental function, disorientation, confusion, decreased motivation, ability to concentrate and initiative, including in encephalopathy and dementia.
Contraindications
- acute stage of hemorrhagic stroke;
- age up to 18 years;
- pregnancy and lactation;
- individual intolerance to the components of the drug.
Instructions for the use of Cereton: method and dosage
- acute conditions (solution): deep intramuscular (slow) or intravenous (slow); 1 ampoule a day for 10-15 days;
- recovery period after craniocerebral trauma, hemorrhagic / ischemic stroke (capsules): inside; 800 mg in the morning and 400 mg in the afternoon for a course of 6 months;
- chronic cerebrovascular insufficiency and dementia syndrome (capsules): inside (preferably after meals); 3 times a day, 400 mg for a course of 3–6 months.
Side effects
The development of nausea is possible (mainly due to dopaminergic activation). Cancellation of Cereton in this case is not required, a temporary dose reduction is shown.
Allergic reactions can also develop.
Additionally for mortar:
- nervous system: aggressiveness, headache, insomnia, drowsiness, anxiety, dizziness, nervousness, convulsions, cerebral ischemia;
- digestive system: pharyngitis, constipation, dryness of the oral mucosa, diarrhea;
- skin: urticaria, rash;
- others: increased urination, pain at the injection site.
Overdose
The main symptom of an overdose is nausea. In these cases, symptomatic treatment is performed.
special instructions
There is no information.
Application during pregnancy and lactation
According to the instructions, Cereton is not prescribed during pregnancy and lactation.
Pediatric use
Age under 18 is a contraindication to therapy, which is due to the lack of data confirming the safety / efficacy of the drug.
Drug interactions
No clinically significant interaction of Tsereton with other drugs / substances has been identified.
Analogs
Tsereton's analogs are Choline alfoscerate, Cholytilin, Cerepro, Delecit, Gleatser, Gliatilin.
Terms and conditions of storage
Store in a place protected from light at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life:
- capsules - 3 years;
- solution - 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Tsereton
According to reviews, Cereton is an effective drug that is relatively inexpensive among analogues. Many people note that when administered intramuscularly and intravenously, it can lead to the development of side effects, including drowsiness. Of the disadvantages of Tsereton capsules, they indicate their large size. Also, in some cases, the drug does not have the expected therapeutic effect.
Price for Cereton in pharmacies
Approximate price for Cereton:
- solution (3, 5 or 10 ampoules per package) - 265–365, 483–577 or 572–577 rubles;
- capsules (14 or 28 pcs. per pack) - 436-580 or 900-1022 rubles.
Cereton: prices in online pharmacies
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Drug name Price Pharmacy |
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Cereton 250 mg / ml solution for intravenous and intramuscular administration 4 ml 3 pcs. 159 r Buy |
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Cereton 400 mg capsule 14 pcs. 363 r Buy |
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Cereton solution for intravenous and intramuscular injection. 250mg / ml 4ml 3 pcs. 396 r Buy |
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Cereton 250 mg / ml solution for intravenous and intramuscular administration 4 ml 5 pcs. 465 RUB Buy |
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Cereton 400 mg capsule 28 pcs. RUB 500 Buy |
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Cereton capsules 400mg 14 pcs. 573 r Buy |
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Cereton solution for intravenous and intramuscular injection. 250mg / ml 4ml 5 pcs. 588 r Buy |
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Cereton capsules 400mg 28 pcs. Artlife 1060 RUB Buy |
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Cereton 400 mg capsule 56 pcs. 1196 RUB Buy |
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Cereton capsules 400mg 56 pcs. RUB 1526 Buy |
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Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
