Psorkutan
Psorkutan: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Psorcutan
ATX code: D05AX02
Active ingredient: calcipotriol (calcipotriol)
Producer: Leo Pharmaceutical Products (Denmark), Schering AG (Poland)
Description and photo update: 2019-23-08
Psorkutan is a drug with an antipsoriatic effect.
Release form and composition
Dosage forms of Psorkutan release:
- Ointment 0.005% (in tubes of 30 g, 1 tube in a cardboard box);
- Cream 0.005% (in tubes of 30 or 100 g, 1 tube in a cardboard box);
- Solution for external use 0.005% (in polyethylene bottles (bottles) of 30 or 60 ml, 1 bottle in a cardboard box).
The active substance is composed of 1 g of ointment or cream and 1 ml of solution: calcipotriol - 0.00005 g.
Pharmacological properties
Pharmacodynamics
Calcipotriol is the most pharmacologically active metabolite of natural vitamin D 3. It interacts with specific receptors localized in keratinocytes, which causes inhibition of the proliferation of these cells of the skin, which is significantly enhanced in patients with psoriasis, and the activation of their morphological differentiation. This effect is dose dependent.
The mechanism of action of calcipotriol lies in the effect of the drug on calcium metabolism (experimental data indicate that the intensity of exposure is 100-200 times less than in the case of calcitriol) in the body and the correction of immune processes in skin cells. The clinically pronounced effect of the drug develops within 1-3 weeks.
Pharmacokinetics
Calcipotriol is characterized by a slight systemic effect and an insignificant effect on the processes of calcium metabolism in the body. Its systemic absorption does not exceed 1%. The substance is rapidly metabolized in the liver, forming pharmacologically inactive metabolites. The drug is excreted in both urine and feces.
Indications for use
According to the instructions, Psorkutan is prescribed for the treatment of psoriasis.
Contraindications
- Pustular psoriasis;
- Psoriasis in a progressive stage;
- Diseases with impaired calcium metabolism;
- Disorders of the kidneys and liver in severe course;
- Hypersensitivity to drug components.
For children under 18 years of age, the drug is prescribed only in short courses in cases where treatment with other drugs does not bring a satisfactory effect.
Psorkutan is not recommended for lactating and pregnant women.
Instructions for use of Psorkutan: method and dosage
Psorkutan solution, cream and ointment are used externally.
Recommended dosage regimen:
- Ointment, cream: the drug should be applied 1-2 times a day to the affected skin. The maximum daily dose is 15 g (no more than 100 g per week). Course duration - no longer than 1 year;
- Solution for external use: the drug should be applied, lightly rubbing, 2 times a day on the affected areas of the scalp (up to 60 ml per week). The duration of the course is determined by the clinical picture.
The total dose of the active substance (calcipotriol) with combined use is no more than 0.005 g per week (30 ml of solution and 60 g of cream or ointment or 60 ml of solution and 30 g of cream or ointment).
Side effects
In some cases, the use of Psorkutan can lead to the development of skin irritation (in the form of itching, burning or redness), as well as dermatitis (perioral area, face).
Overdose
When using Psorkutan in large doses, it is possible to increase the concentration of calcium in the blood plasma (hypercalcemia), which is transient and disappears when the dose is reduced or the drug is withdrawn.
It has been proven that when more than 100 g of ointment or cream is applied for 1 week, patients may develop symptoms such as hypercalciuria, hypercalcemia, nausea, vomiting, abdominal pain, thirst, decreased appetite, weight loss, constipation, increased blood pressure, feeling of severe fatigue, depression. In this case, it is recommended to immediately discontinue the drug and carry out intensive (parenteral and oral) hydration of the body. Also, forced diuresis (accompanied by taking furosemide to increase the rate of excretion of calcipotriol) and hemodialysis (in patients with renal failure) are used. Good results in overdose are given by the administration of potassium chloride, which prevents hypokalemia, and glucocorticosteroids (GCS). Regular monitoring of water and electrolyte balance and control of daily urine output are required.
special instructions
Psorkutan should not be applied to the skin of the face (the exception is the border of hair growth).
Avoid getting the drug on mucous membranes or intact skin areas.
Application during pregnancy and lactation
Experimental studies have not confirmed the presence of embryotoxic and teratogenic effects of the drug, however, due to the lack of sufficient data on the use of Psorkutan during pregnancy, it is not recommended to prescribe it to women carrying a child.
There is no data on whether calcipotriol is excreted in breast milk or not, therefore, if the drug is used during lactation, it is recommended to stop breastfeeding.
Pediatric use
Due to the lack of sufficient data on the use of the drug in children and adolescents under the age of 18, it is not recommended to use the drug in patients of this age group. The doctor may decide to prescribe Psorkutan to patients under 18 years of age for the shortest possible course, provided that treatment with other drugs does not bring a satisfactory result.
With impaired renal function
In case of severe renal impairment, the drug is prohibited for use.
For violations of liver function
In case of severe violations of liver function, the drug is prohibited for use.
Drug interactions
Combination therapy with salicylic acid and drugs containing it is not recommended.
Combined use of Psorkutan with selective phototherapy (SFT) and photochemotherapy (PUVA) is possible.
Analogs
The analogues of Psorkutan are: Glenriaz, Daivonex, Calcipotriol, Daivobet, Ksamiol.
Terms and conditions of storage
Keep out of reach of children at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Psorkutan
There are practically no reviews of Psorkutan on the Internet. Some patients used the drug about 5–8 years ago, but now they use more modern analogues. In some sources, there are references to the fact that Psorkutan is capable of exacerbating psoriasis.
Price for Psorkutan in pharmacies
The approximate price of Psorkutan ointment is about 1,850 rubles (for a 30 g tube). The cream can be purchased for approximately 1520-1800 rubles (for a 30 g tube), and a solution for external use - for 2000 rubles (a 30 ml bottle).
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
