Uregit
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Uregit is a fast-acting diuretic.
Release form and composition
Dosage form - tablets: round, flat, white or grayish-white, with a bevel, with UREGYT engraving on one side and a line on the other, practically odorless (10 pcs. In blisters, 2 blisters in a cardboard box).
Active ingredient: ethacrynic acid, in 1 tablet - 50 mg.
Auxiliary components: gelatin, potato starch, magnesium stearate, talc, lactose monohydrate.
Indications for use
- edema against the background of portal hypertension;
- edema of the renal, cardiac and post-thrombotic type;
- conditions in which other diuretic drugs have been ineffective.
Contraindications
- rare hereditary galactose intolerance, lactase deficiency, glucose and galactose malabsorption syndrome;
- hepatic coma;
- severe violations of the water-electrolyte balance and acid-base state;
- anuria;
- age up to 18 years;
- lactose intolerance;
- pregnancy and lactation;
- hypersensitivity to any component of the drug.
Carefully:
- primary hyperaldosteronism;
- violations of water and electrolyte balance;
- cirrhosis of the liver, including with ascites;
- hypomagnesemia;
- hypokalemia;
- connective tissue diseases (systemic lupus erythematosus);
- elderly age.
Method of administration and dosage
Uregit is a drug for oral administration. It is advisable to take it in the morning after breakfast.
The initial dosage is 50 mg once a day, then the dose is gradually increased until the desired effect is achieved.
The maximum allowable daily dose is 200 mg.
For a gradual diuretic effect, a minimum dose of 25 mg is sufficient.
For adults, a daily dose of 50–100 mg is usually sufficient to achieve the desired diuretic effect.
The usual maintenance daily dose is 25-200 mg. To maintain the effectiveness of Uregit, therapy can be carried out intermittently: take the drug at intervals of 1-2 or 2-3 days.
A dose reduction is required in elderly patients.
If necessary, Uregit can be prescribed in combination with other diuretics.
Diuresis should be monitored regularly during treatment.
Side effects
Classification of side effects depending on the frequency of their development: often - from ≥ 1/100 to <1/10, infrequently - from ≥ 1/1000 to <1/100, rarely from ≥ 1/10 000 to <1/1000, very rarely - <1/10 000, frequency is unknown - it is not possible to establish the frequency of occurrence of adverse reactions based on the available clinical data.
Possible side effects:
- from the gastrointestinal tract: often - diarrhea, nausea, pain and discomfort in the abdomen, vomiting, dysphagia; very rarely - gastrointestinal bleeding, profuse diarrhea, acute pancreatitis; with the simultaneous use of several drugs - jaundice, increased activity of liver enzymes;
- on the part of the central nervous system: often - increased fatigue, headache; rarely - impaired consciousness, anxiety;
- from the urinary system: hematuria;
- from the hematopoietic and lymphatic system: rarely - thrombocytopenia; in several critically ill patients who were prescribed the drug for a diuretic effect, severe neutropenia and agranulocytosis occurred;
- from the side of metabolism: hyperuricemia, anorexia, hyperglycemia, hypoglycemia, gout attack;
- on the part of the skin: rarely - a rash, Shenlein's disease - Henoch;
- on the part of the organs of vision and hearing: dizziness with a feeling of stuffiness in the ears, blurred vision, ringing in the ears, deafness, including irreversible (especially in patients receiving simultaneously drugs with ototoxic effects;
- laboratory parameters: lowering the level of blood glucose, calcium, potassium, magnesium, chlorides, uric acid, sodium, blood nitrogen;
- others: fever, chills.
Overdose symptoms: excessive diuresis, dehydration, loss of electrolytes, decreased blood pressure. There is no specific antidote. Ethacrynic acid is poorly removed from the bloodstream by hemodialysis. In case of overdose, induce vomiting, flush the stomach. Treatment is symptomatic and supportive. If indicated, it is necessary to correct electrolyte disturbances, eliminate dehydration and hepatic coma. If breathing is impaired, oxygen inhalation and / or artificial ventilation is indicated.
special instructions
In order to avoid dehydration, it is recommended to start treatment with minimum doses, increasing them gradually.
With great caution, Uregit should be prescribed to patients with cirrhosis of the liver, since diuretics increase the risk of developing hepatic coma, which can be fatal.
During the period of therapy, it is advisable to eat foods rich in potassium. You should regularly monitor the content of electrolytes, if necessary, prescribe additional potassium supplements.
Many patients on diuretics do not need potassium supplementation. However, the addition of potassium chloride or the use of potassium-sparing diuretics is recommended for patients with nephrotic syndrome and cirrhosis, as well as for patients receiving digitalis preparations.
People with normal kidney function can be given potassium supplements (by regularly monitoring their plasma levels) because excess potassium is excreted from the body. Potassium should not be administered in renal failure. The doctor always sets the indications and contraindications for the administration of potassium individually, depending on its content in the blood plasma.
To enhance the diuretic effect, Uregit can be used in combination with other diuretics.
If diarrhea develops, accompanied by a large loss of fluid, the drug should be discontinued.
Ethacrynic acid can enhance the effect of simultaneously used antihypertensive drugs, which increases the risk of developing orthostatic collapse.
The risk of developing orthostatic hypotension increases with the concomitant intake of barbiturates, diazepam and alcohol.
At a high risk of metabolic alkalosis (in patients with cirrhosis accompanied by ascites), the use of potassium-sparing diuretics or the administration of potassium chloride can reduce or prevent hypokalemia.
With excessive diuresis, the drug should be temporarily canceled until the water-electrolyte state stabilizes. With large losses of electrolytes, you can reduce the dose of the drug or temporarily stop therapy.
Excessive loss of fluid in the urine (expressed by a rapid and pronounced decrease in body weight) can lead to the development of severe hypotension. In elderly people with concomitant cardiac pathologies, excessive diuresis may be accompanied by a decrease in the volume of circulating plasma, which increases the risk of thromboembolic complications.
Loop diuretics reduce the level of magnesium ions in the blood.
The drug can cause hypokalemia, against which the effect of cardiac glycosides may increase.
With the simultaneous use of hormonal drugs that induce potassium loss (corticosteroids), laboratory monitoring is necessary.
During therapy, you should stop drinking alcoholic beverages.
Physicians should warn athletes that ethacrine therapy may bias the results of doping control tests.
At the beginning of treatment, it is recommended to refrain from engaging in potentially hazardous activities that require motor and mental reactions. The degree of further restriction is determined individually, depending on the tolerability of the drug.
Drug interactions
- anticoagulants (coumarin, warfarin): their effect is enhanced (it is necessary to adjust the dose of the anticoagulant or transfer the patient to furosemide);
- ethanol, antihypertensive drugs: an increase in the diuretic and / or hypotensive effect is possible;
- oral hypoglycemic drugs: their effectiveness decreases;
- lithium: its level in the blood rises, and intoxication may develop;
- non-steroidal anti-inflammatory drugs: the diuretic or antihypertensive effect is weakened;
- aminoglycosides, cephalosporins: their ototoxicity increases (it is recommended to avoid such combinations);
- corticosteroids: the risk of hypokalemia and bleeding from the gastrointestinal tract increases;
- angiotensin-converting enzyme (ACE) inhibitors: the likelihood of severe arterial hypotension increases (at the initial stage of the use of ACE inhibitors, their dose should be reduced or Uregit should be stopped).
Analogs
Uregit's analogs are: Hydromedin, Otacryl, Krinuril, Edecrin, Edecril, Erineks, Ethacrynic acid.
Terms and conditions of storage
Keep out of reach of children at a temperature of 15-25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
