Kolhikum-Dispert
Kolhikum-Dispert: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Use in old age
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Colchicum-Dispert
ATX code: M04AC01
Active ingredient: Magnificent colchicum alkaloid (Colchic speciosi alkaloid)
Manufacturer: Solvay Pharmaceuticals GmbH (Germany)
Description and photo update: 2019-07-08
Prices in pharmacies: from 779 rubles.
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Kolhikum-Dispert is a drug that affects the exchange of uric acid, an anti-gout agent.
Release form and composition
Dosage form - coated tablets: round, dark red, with a shiny surface (20 pcs in a blister, 1 blister in a cardboard box; 25 pcs in a blister, 2 blisters in a cardboard box).
Active ingredient: dry extract of autumn colchicum seeds, in 1 tablet - 15.6 mg, which corresponds to the content of the sum of alkaloids in terms of colchicine - 0.5 mg.
Additional components: corn starch, white wax, cochineal carmine A, palmitic / stearic acid, sucrose, sodium carmellose, light magnesium oxide, povidone K25, gum arabic, copovidone, magnesium stearate, carnauba wax, microcrystalline cellulose, titanium oxide, sodium macrogol 6000 sulfate, lactose monohydrate, talc, shellac, amaranth dye (E123).
Pharmacological properties
Pharmacodynamics
Colchicine - the active component of Kolhicum-Dispert - has an anti-gout effect due to inhibition of the phagocytosis of microcrystals of uric acid salts and a decrease in the migration of leukocytes to the inflammation focus. It is also characterized by antimitotic action. The drug completely or partially inhibits cell division in the metaphase and anaphase stages, prevents neutrophil degranulation and prevents the development of amyloidosis by suppressing the formation of amyloid fibrils.
Colchicine is highly effective in relieving attacks of acute gout. In the first 12 hours after the start of taking the drug, the condition improves significantly in more than 75% of patients. In 80% of patients, adverse reactions from the gastrointestinal tract may occur before clinical improvement or simultaneously with it.
Taking Kolkhikum-Dispert every day in a daily dose of 1-2 mg reduces the risk of recurrent acute attacks in 3/4 of patients suffering from gout. The drug is a means of preventing acute attacks in patients with familial Mediterranean fever (by reducing the activity of dopamine beta-hydroxylase). Treatment with Kolkhikum-Dispert increases life expectancy in patients with primary AL-amyloidosis and has a positive effect on the condition of the skin (softens and reduces dryness) in systemic scleroderma.
Pharmacokinetics
Colchicine is absorbed intensively and rapidly from the gastrointestinal tract. Its maximum plasma level averages 4.2 ng / ml and is reached approximately 70 minutes after taking a dose of 1 mg. The half-life is 9.3 hours. Colchicine has a high volume of distribution (473 liters) and rapidly penetrates into tissues. High concentrations of this substance are determined in the digestive tract, liver, spleen, kidneys and leukocytes. Colchicine is involved in metabolic processes in the liver and is excreted mainly in the bile.
Enterohepatic circulation is recorded 4–6 hours after colchicine enters the body. Most of the dose received is excreted through the intestines and about 23% through the kidneys.
Indications for use
- Acute gout attacks;
- Familial Mediterranean fever (periodic illness).
Contraindications
Absolute:
- Expressed inhibition of bone marrow hematopoiesis;
- Hepatic or renal failure;
- Pregnancy and lactation;
- Hypersensitivity to the drug.
Relative:
- Severe dysfunction of the cardiovascular system;
- Severe dysfunction of the gastrointestinal tract;
- Cachexia;
- Elderly age.
Instructions for use Kolhikum-Dispert: method and dosage
The tablets should be taken orally: swallow whole and drink them with a sufficient amount of liquid.
To relieve an acute gout attack, you must first take 2 tablets at once, then 1-3 tablets every 1-2 hours until the pain syndrome subsides. The total daily dose should not exceed 8 mg (16 tablets). In the case of a new attack of gout, it is possible to repeat the treatment according to the described scheme, but not earlier than 3 days later.
For the prevention of acute attacks of gout, the drug is prescribed 1-3 tablets daily or every other day for the first few months (usually 3) of treatment with uricosuric agents.
Side effects
Possible: stomach pain, nausea, vomiting, diarrhea, in rare cases - leukopenia.
With prolonged use of the drug in some cases, myopathy and neuropathy occur, even less often - hypoplastic anemia, agranulocytosis, alopecia.
Overdose
Symptoms of acute drug intoxication were observed in adults after taking a dose of about 20 mg and in children after taking a dose of 5 mg.
Chronic intoxication is noted in patients suffering from gout after taking Kolhikum-Dispert in a total dose of 10 mg or higher for several days.
Since colchicine is characterized by antimitotic activity, organs in which an increased proliferation rate is observed are most often affected.
Approximately 2-6 hours after taking the drug in doses exceeding therapeutic doses, patients develop thirst, difficulty swallowing, a sore throat and a burning sensation in the throat and mouth, nausea, vomiting and urge to it, and after a short period of time - colic, tenesmus, urge to urinate and defecate (usually in emaciated patients).
Hemorrhagic and / or muco-watery diarrhea can lead to loss of fluid and electrolytes, which leads to the development of metabolic acidosis, hyponatremia and hypokalemia. Often, patients complain of both pain and a feeling of tightness in the heart. In the future, they have dyspnea, a decrease in body temperature, pallor and cyanosis of the skin. The development of tachycardia and arterial hypotension, ending in collapse, is not excluded.
Neurological disorders are expressed in the form of seizures, weakening sensitivity and signs of paralysis. In the first 3 days, a lethal outcome is possible due to paralysis of the respiratory center and cardiovascular failure.
After 1-2 weeks after treatment, intoxication in patients may appear complete, sometimes prolonged alopecia. In some cases, dysfunctions of the liver, kidneys and lungs are noted. Occasionally, patients are struck by blindness.
In case of an overdose, only symptomatic treatment is possible, aimed at stabilizing the cardiovascular system. Plasma substitutes or isotonic sodium chloride solution with the addition of electrolytes (mainly potassium) and glucose are injected intravenously. Continuous ECG monitoring is recommended.
To normalize myocardial contractility, digoxin is prescribed. If necessary, antibiotic therapy is performed. If an increased pressure of cerebrospinal fluid is detected, the use of dexamethasone is recommended, and, if necessary, a lumbar puncture. For abdominal cramps, it is advisable to use papaverine, atropine or tanalbin. The prescription of opiates is prohibited. If necessary, artificial respiration or oxygen therapy sessions are performed.
special instructions
During treatment, it is necessary to carry out clinical and hematological control.
With the development of pronounced side effects from the digestive system, the dose of the drug should be reduced or canceled altogether.
In the case of a decrease in the number of platelets below 100,000 / μl and leukocytes below 3000 / μl, the use of the drug is stopped until the blood picture is normalized.
According to the instructions, Kolhikum-Dispert does not adversely affect the speed of reactions and the patient's ability to concentrate.
Use in the elderly
The drug is prescribed with extreme caution to elderly patients.
Drug interactions
- Cyclosporine: the likelihood of developing myopathy increases, especially in patients with functional renal impairment;
- Cyanocobalamin: its absorption is impaired;
- Deprimating and sympathomimetic agents: their effect is enhanced;
- Non-steroidal anti-inflammatory drugs and other drugs that cause myelodepression: the risk of thrombocytopenia and leukopenia increases;
- Cytostatics and drugs that acidify urine: the anti-gout activity of colchicine decreases;
- Urine alkalizing agents: enhances the effect of colchicine.
If necessary, Kolhikum-Dispert can be used simultaneously with allopurinol and uricosuric drugs.
Analogs
The analogue of Kolkhikum-Dispert is Colchicine.
Terms and conditions of storage
Store out of the reach of children and protected from light. Do not exceed a temperature of 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Kolhikum-Dispert
According to reviews, Kolhikum-Dispert relieves gout attacks well and, with systematic treatment, eliminates purine metabolism disorders. The greatest effect can be achieved if the drug is used in the first hours after the onset of an attack.
The drug provides the retrograde development of arthritis for several hours, but it must be taken every 2 hours until the pain almost completely disappears (no more than 16 tablets per day). However, patients say that due to the development of side effects - nausea, vomiting, diarrhea, hemorrhagic gastroenteritis - it is often not possible to increase the dose to the optimal one.
Since the drug is toxic, some experts practice the prescription of colchicine in small doses and non-steroidal anti-inflammatory drugs in combination. It should also be borne in mind that the toxicity of drugs increases when they are taken by patients with kidney disease.
The reviews also mention the high cost of Kolhikum-Dispert, the presence of a large number of fakes, and the rare purchase of the drug by pharmacies.
Price for Kolhikum-Dispert in pharmacies
The average price for Kolhikum-Dispert in pharmacies is about 700–990 rubles per pack of 20 tablets (depending on the region).
Kolhikum-Dispert: prices in online pharmacies
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Drug name Price Pharmacy |
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Kolhikum-dispersion 0.5 mg film-coated tablets 20 pcs. 779 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
