Mardil Zinc
Mardil Zinc: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Mardil Zink
ATX code: G02CX
Active ingredient: a solution of zinc 2-chloropropionate in 2-chloropropionic acid (Solution zincum 2-chloropropionate in 2-chloropropionic acidum)
Producer: ZAO Pharmcenter VILAR (Russia)
Description and photo update: 2019-08-10
Prices in pharmacies: from 500 rubles.
Buy
Mardil Zinc is a local necrotizing agent.
Release form and composition
The drug is available in the form of a solution for topical use: a transparent, colorless or light yellow liquid, has a specific odor (1 ml each in dark glass vials, 1 bottle each in a foam container, 1 container in a cardboard box and instructions for use Mardil Zinc).
1 ml of solution contains:
- active substance: 1.5% solution of zinc 2-chloropropionate in 2-chloropropionic acid (semi-finished product solution) - 0.3 ml;
- auxiliary component: purified water - up to 1 ml.
Pharmacological properties
Pharmacodynamics
Mardil Zinc is a local non-necrotizing drug that has a cauterizing and mummifying effect in the treatment of benign skin lesions. Its active ingredient is a 30% aqueous solution of zinc chloropropionate and 2-chloropropionic acid. When applied to the affected areas of the mucous membrane, the solution is able to stop the growth and vital activity of benign neoplasms or pathologically altered cells and tissues by devitalization, angiocoagulation and dehydration. The effect of the drug on the affected areas of the mucous membrane leads to the fixation of pathological changes and subsequent necrotization of the tissue, the process is accompanied by discoloration and the acquisition of a characteristic pale gray tint by the mucous membrane.
When the drug is applied to the ectopic columnar epithelium, coagulation and devitalization of the cervical ectopia and the transformation zone occurs. At the same time, the intact multilayer squamous epithelium of the vaginal part of the cervix and the vaginal mucosa is resistant to the effects of the drug, remaining practically intact. In the absence of a secondary infection, healing is not accompanied by complications, scarring or deformation of adjacent tissues and organ dysfunctions.
Pharmacokinetics
When applied to the affected areas of the mucous membrane, the solution is not absorbed into the systemic circulation and has no effect on the body.
Indications for use
The use of Mardil Zinc is indicated for the treatment of benign formations of the mucous membranes of the vagina and cervix: cervical ectopia, anogenital warts.
Contraindications
- malignant neoplasms of the cervix, vagina or anogenital zones;
- cervical intraepithelial neoplasia (CIN);
- period of pregnancy;
- breast-feeding;
- age up to 18 years;
- hypersensitivity to the active substance of the drug.
Mardil Zinc, instructions for use: method and dosage
Mardil Zinc solution is intended for topical use by applying only to altered tissues using a universal probe or applicator. Do not allow the drug to get on a healthy mucous membrane.
The dose of the drug depends on the area of the lesion.
Treatment of ectopia should be started only on the basis of the results of oncocytological examination of smears-prints. The procedure using a colposcope should be performed by a gynecologist or dermatovenerologist. The vagina and cervix must first be prepared for treatment by removing vaginal mucus with a cotton swab. The drug is applied once in a dose of 0.02 to 0.2 ml. The maximum daily dose is 0.2 ml. The manifestation of the effect is the staining of the tissue in a whitish-yellow color, followed by a reduction in the scab and its rejection. The epithelialization process can last from 14 to 42 days, depending on the size of the ectopia.
Treatment of anogenital warts is carried out under the supervision of a physician on an outpatient basis. The procedure can be performed without the use of anesthesia. After applying the solution, the color of the fabrics becomes whitish-gray. The number of applications and the dose of Mardil Zinc depend on the area of the mucosal lesion and the size of the neoplasms, the dose can vary from 0.02 to 0.2 ml. The maximum daily dose is 0.2 ml.
Treatment of extensive lesions is carried out in several stages, processing during one procedure no more than 2-3 lesions with a total area of up to 3 cm 2. The interval between procedures should be at least one day. Application of the solution is accompanied by slight edema of the mucous membrane. Rejection of necrotic tissue occurs within 2–3 days after using the drug. Full regeneration takes 10-14 days. If large anogenital warts are incompletely necrotic, they can be re-treated with the solution after 5-7 days.
Side effects
- from the immune system: allergic reactions in patients with individual intolerance to the active component of the drug;
- local reactions: possibly - tissue edema, short burning and / or itching.
Overdose
If used incorrectly, mucosal erosion may occur.
In case of excessive application of the drug, the area must be rinsed with running water, this will prevent acid burns of tissues. To potentiate the healing process, the use of wound healing agents for local application is allowed.
special instructions
The bottle should be shaken before opening so that all the contents move to its bottom. Care should be taken to keep the opened bottle strictly upright. Any contact of acid with healthy skin or mucous membranes should not be allowed. If the drug accidentally gets on healthy skin or mucous membranes, it must be removed with a cotton swab moistened with water as soon as possible. If the drug gets into the eyes, they are washed with plenty of water and 1% sodium bicarbonate solution. If necessary, consult a doctor.
After carrying out medical manipulation, you can carry out hygienic procedures, but you can not take baths, visit baths, saunas, swimming pools or swim in open water.
Before throwing the bottle into a waste container, rinse off the remaining solution under running water.
Application during pregnancy and lactation
The use of Mardil Zinc solution is contraindicated during gestation and during breastfeeding.
Pediatric use
The use of Mardil Zinc is contraindicated for the treatment of patients under the age of 18 years.
Drug interactions
The interaction of Mardil Zinc with other topical drugs has not been established.
Analogs
Mardil Zinc analogs are Mardil Zinc Max, Solkovagin, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C in a dark place.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Mardil Zink
There are no reviews about Mardil Zink.
Price for Mardil Zinc in pharmacies
The price of Mardil Zinc is unknown due to its absence in the pharmacy chain. An analogue of the drug, Mardil Zinc Max, can be purchased for 1200-1380 rubles.
Mardil Zinc: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Mardil Zinc Max solution for local and external use 0.5 ml / 1 ml 1 pc. RUB 500 Buy |
|
Mardil zinc max solution for local and outdoor. approx. set 1 piece 1649 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
